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Engineered Sulfated Polysaccharides for Biomedical Applications

open access: yesAdvanced Functional Materials, 2021
AbstractSulfated polysaccharides are ubiquitous in living systems and have central roles in biological functions such as organism development, cell proliferation and differentiation, cellular communication, tissue homeostasis, and host defense. Engineered sulfated polysaccharides (ESPs) are structural derivatives not found in nature but generated ...
Øystein Arlov   +4 more
openaire   +3 more sources

Photocrosslinkable polysaccharides based on chondroitin sulfate [PDF]

open access: yesJournal of Biomedical Materials Research Part A, 2003
AbstractPhotopolymerizing hydrogels have demonstrated potential for use as a scaffold in numerous tissue‐engineering applications. The majority of photopolymerizing hydrogels are made from purely synthetic polymers. The purpose of this study was to synthesize and characterize photopolymerizing hydrogels derived from the biopolymer chondroitin sulfate ...
Qiang, Li   +5 more
openaire   +2 more sources

Effects of sulfated polysaccharides on tumour biology

open access: yesWest Indian Medical Journal, 2006
Sulfated polysaccharides can act not only as anticoagulants but also as tumour inhibitors. Recent studies suggest that sulfated polysaccharides could affect tumour cells directly. Sulfated polysaccharides could inhibit the metastasis and proliferation of tumour cells by binding to growth factors and cell adhesion molecules.
X Z, Wu, D, Chen
openaire   +2 more sources

[Antiviral action of sulfated polysaccharides].

open access: yesAntibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2009
The literature data on the structure and biological spectrum of sulfated polysaccharides (fucoidans) from the sea brown algae are presented. The review includes the data on the experimental studies and the results of the author's researches on the sulfated polysaccharides inhibitory action on virus adsorption on eukaryotic cells.
I. D. Makarenkova   +2 more
openaire   +2 more sources

Structure and Bioactivity of Sulfated Polysaccharides

open access: yesTrends in Glycoscience and Glycotechnology, 2003
グリコサミノグリカンを含む酸性多糖類は様々な化学的、生物学的な機能を示す。これらの機能の多くは硫酸基の存在に強く依存している。よってこれら多糖類の部分的硫酸化、完全硫酸化あるいは脱硫酸化などの化学的修飾は、硫酸化多糖の示す機能を制御できるものと期待されている。多糖類の化学的修飾に関する論文は数多く、私たちもこれまで多糖類の化学修飾のみならずその生物学的作用に関して検討してきた(構造-活性相関、SAR)。本論文では天然および化学修飾した多糖類の構造活性相関について最近の結果を示す。
Toida, Toshihiko   +2 more
openaire   +2 more sources

The specificity of interactions between proteins and sulfated polysaccharides [PDF]

open access: yesAnais da Academia Brasileira de Ciências, 2005
Sulfated polysaccharides are capable of binding with proteins at several levels of specificity. As highly acidic macromolecules, they can bind non-specifically to any basic patch on a protein surface at low ionic strength, and such interactions are not likely to be physiologically significant.
openaire   +5 more sources

COMPARISON OF THE ANTICOAGULANT ACTION OF SULFATED AND PHOSPHORYLATED POLYSACCHARIDES

open access: yesThrombosis Research, 1997
Oat spelts xylan (OSX), fucoidan, kappa carrageenan and chondroitin sulfates A and C were sulfated using chlorosulfonic acid-pyridine complex while the first three were phosphorylated using methane sulfonic acid-phosphorous pentoxide mixture. The compounds were isolated as the sodium salts and their in vitro anticoagulant properties were determined by ...
Chemistry Department, Prairie View A&M University, Prairie View, TX 77446, USA ( host institution )   +6 more
openaire   +3 more sources

NEUROPROTECTIVE EFFECTS OF SULFATED POLYSACCHARIDES FROM SEAWEED

open access: yesAnnals of the Russian academy of medical sciences, 2013
Currently, neurodegenerative diseases (NDD) occupy a significant place in the structure of disease of the elderly, which dictates the need to find new and effective treatment and prevention of this pathology. At the heart of NDD development is a violation of the metabolism and the conformational change of cellular proteins with subsequent accumulation ...
N N, Besednova   +3 more
openaire   +3 more sources

The influence of sulfated polysaccharides on the circulating levels of hyaluronan [PDF]

open access: yesGlycobiology, 1997
When chondroitin sulfate (CS) or dextran sulfate (DxS) was administered intravenously in rats the levels of circulating hyaluronan (HA) rapidly increased. 70 min after injection the levels were found to be about 10-20 times the initial values. Saline injections were without effect on HA levels.
openaire   +2 more sources

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