Structural Analysis and Anticoagulant Activities of the Novel Sulfated Fucan Possessing a Regular Well-Defined Repeating Unit From Sea Cucumber [PDF]
Marine Drugs, 2015 Sulfated fucans, the complex polysaccharides, exhibit various biological activities. Herein, we purified two fucans from the sea cucumbers Holothuria edulis and Ludwigothurea grisea. Their structures were verified by means of HPGPC, FT-IR, GC–MS and NMR.
Longyan Zhao, Mingyi Wu, Jinhua Zhao
exaly +5 more sources
Structure-function relationship of the GH168 fucanase reveals an unusual enzyme recognition mechanism for sulfated polysaccharide [PDF]
Nature CommunicationsSulfated fucan is one of the most recalcitrant polysaccharides. The molecular mechanism underlying the endo-1,3-fucanase, which plays a critical role in the breakdown of sulfated fucan, remains unexplained.
Guangning Chen +15 more
doaj +3 more sources
Fucose-Rich Sulfated Polysaccharides from Two Vietnamese Sea Cucumbers Bohadschia argus and Holothuria (Theelothuria) spinifera: Structures and Anticoagulant Activity [PDF]
Marine Drugs, 2022 Fucosylated chondroitin sulfates (FCSs) FCS-BA and FCS-HS, as well as fucan sulfates (FSs) FS-BA-AT and FS-HS-AT were isolated from the sea cucumbers Bohadschia argus and Holothuria (Theelothuria) spinifera, respectively.
Nadezhda E. Ustyuzhanina +11 more
doaj +3 more sources
Monoclonal antibodies directed to fucoidan preparations from brown algae. [PDF]
PLoS ONE, 2015 Cell walls of the brown algae contain a diverse range of polysaccharides with useful bioactivities. The precise structures of the sulfated fucan/fucoidan group of polysaccharides and their roles in generating cell wall architectures and cell properties ...
Thomas A Torode +6 more
doaj +4 more sources
Marine Drugs, 2021 Marine organisms are a source of active biomolecules with immense therapeutic and nutraceutical potential. Sulfated fucose-rich polysaccharides are present in large quantities in these organisms with important pharmacological effects in several ...
Roberto J. C. Fonseca +1 more
doaj +2 more sources
Red Algal Sulfated Galactan Binds and Protects Neural Cells from HIV-1 gp120 and Tat [PDF]
Pharmaceuticals, 2021 The potential neuroprotective capacity of four different sulfated glycans: Botryocladia occidentalis-derived sulfated galactan (BoSG) (MW > 100 kDa), Lytechinus variegatus-derived sulfated fucan (LvSF) (MW~90 kDa), high-molecular weight dextran sulfate ...
Vitor H. Pomin +5 more
doaj +3 more sources
Analysis Methods and Structure–Activity Relationships of Polysaccharides in Sea Cucumber: A Review [PDF]
Marine DrugsSea cucumber polysaccharide is a kind of heteropolysaccharide rich in sulfate groups, which has complex structures and various biological activities. Its biological activity is closely related to its chemical composition, molecular weight, and sulfated ...
Xingyu Gu +10 more
doaj +2 more sources
Purification and Structural Analyses of Sulfated Polysaccharides from Low-Value Sea Cucumber Stichopus naso and Anticoagulant Activities of Its Oligosaccharides [PDF]
Marine DrugsThree polysaccharides (SnNG, SnFS and SnFG) were purified from the body wall of Stichopus naso. The physicochemical properties, including monosaccharide composition, molecular weight, sulfate content, and optical rotation, were analyzed, confirming that ...
Lige Cui +10 more
doaj +2 more sources
Antioxidant Activity of Fucoidan Modified with Gallic Acid Using the Redox Method
Marine Drugs, 2022 Antioxidant compounds decrease the amount of intracellular reactive oxygen species (ROS) and, consequently, reduce the deleterious effects of ROS in osteoblasts.
Keylla Dayanne Coelho Marinho de Melo +7 more
doaj +1 more source
Molecular Plant-Microbe Interactions, 2003 Sulfated fucans are common structural components of the cell walls of marine brown algae. Using a fucan-degrading hydrolase isolated from a marine bacterium, we prepared sulfated fucan oligosaccharides made of mono- and disulfated fucose units ...
Olivier Klarzynski +5 more
doaj +1 more source