Results 181 to 190 of about 1,628 (214)
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New natural polysaccharides with potent antithrombic activity: fucans from brown algae
Biomaterials, 1989Fucans extracted from brown algae exhibit anticoagulant properties, as demonstrated by coagulation assays and kinetic study of the inactivation of thrombin in the presence of antithrombin III. These derivatives exert a direct antithrombic activity by an antithrombin III-independent pathway.
V, Grauffel +4 more
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Relationship between antithrombotic activities of fucans and their structure
Drug Development Research, 2000AbstractA low molecular weight fucan fraction extracted from the brown seaweed Ascophyllum nodosum was previously shown to exhibit dose‐related venous antithrombotic activity with an ED80 of about 20 mg/kg, 2 h after a single subcutaneous injection HCII (Colliec et al. [1991] Thromb Res 64:143–154; Mauray et al. [1995] Thromb Haemast 74:1280–1285). Its
Catherine Boisson‐Vidal +8 more
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A comprehensive review of sulfated fucan from sea cucumber: Antecedent and prospect
Carbohydrate PolymersSulfated fucan from sea cucumber is mainly consists of L-fucose and sulfate groups. Recent studies have confirmed that the structure of sulfated fucan mainly consists of repeating units, typically tetrasaccharides. However, there is growing evidence indicating the presence of irregular domains with heterogeneous units that have not been extensively ...
Long Yu, Yaoguang Chang
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2020
Norovirus infections belong to the most common causes of human gastroenteritis worldwide, and epidemic outbreaks are responsible for hundreds of thousands deaths annually. Strikingly, no antiviral treatment is available due to the difficulty in cultivating virions or in generating a vaccine, and due to the fact that their infection mechanisms are ...
Franz-Georg, Hanisch, Cem, Aydogan
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Norovirus infections belong to the most common causes of human gastroenteritis worldwide, and epidemic outbreaks are responsible for hundreds of thousands deaths annually. Strikingly, no antiviral treatment is available due to the difficulty in cultivating virions or in generating a vaccine, and due to the fact that their infection mechanisms are ...
Franz-Georg, Hanisch, Cem, Aydogan
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Inhibition of complement activation by natural sulfated polysaccharides (fucans) from brown seaweed
Molecular Immunology, 1994In the present study, we demonstrate that natural sulfated polysaccharides (fucans) isolated from brown seaweed are potent inhibitors of human complement activation. A fucan fraction of chromatographic molecular weight 22,600, termed BS8, was found to inhibit classical and alternative pathway activation in whole serum in a dose-dependent fashion. Fucan
C, Blondin +4 more
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Structural studies of the water-soluble fucan from lessonia nigrescens
Carbohydrate Research, 1984Abstract Partial hydrolysis of the water-soluble “fucan” from Lessonia nigrescens gave monosaccharides, neutral and acidic oligosaccharides, a soluble polymer, and an insoluble residue. The neutral oligosaccharides, consisting solely of galactose, were separated into six fractions.
Elizabeth Percival +2 more
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Antithrombin activity of a fucan sulfate from the brown seaweed Ecklonia kurome
Thrombosis Research, 1991The mechanism of antithrombin action of a fucan sulfate (C-II), which was isolated from the brown seaweed Ecklonia kurome, was examined by clotting method using a thrombin-fibrinogen system and by amidolytic method using a chromogenic substrate in the presence and the absence of antithrombin III (AT III) or heparin cofactor II (HC II).
T, Nishino, Y, Aizu, T, Nagumo
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Low molecular weight fucan prevents transplant coronaropathy in rat cardiac allograft model
Transplant Immunology, 2006Transplant arteriosclerosis is the main cause of long-term failure after cardiac transplantation. Vascular rejection is thought to be due to intimal proliferation occurring in response to arterial wall immune-mediated injury. A low molecular weight fucan (LMWF) compound, a sulfated polysaccharide, has been demonstrated to increase plasma levels of ...
Bassam, Alkhatib +8 more
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Further data on the structure of brown seaweed fucans: relationships with anticoagulant activity
Carbohydrate Research, 1999The composition, molecular weight (MW), anticoagulant activity and nuclear magnetic resonance spectra of various low-molecular-weight fucans (LMWFs) obtained by partial hydrolysis or radical depolymerization of a crude fucoidan extracted from the brown seaweed Ascophyllum nodosum are compared. Fucose units were found mainly sulfated at O-2, to a lesser
L, Chevolot +6 more
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Use of Sulfated Fucans as Anticoagulant and Antithrombotic Agents: Future Perspectives
Current Pharmaceutical Design, 2004Sulfated alpha-L-fucans from brown algae (also known as fucoidan) have complex and heterogeneous structures but recent studies revealed the occurrence of ordered repeat units in the sulfated fucans from several species. Even in these cases, the presence of highly branched portions and the complex distributions of sulfate and acetyl groups highlight the
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