Results 71 to 80 of about 1,628 (214)

Structural Characterization and Physicochemical Property of a Purified Fucosylated Glycosaminoglycan Sulfate From Holothuria leucospilota

eFood, Volume 6, Issue 4, August 2025.
(1) The main chain structure of Holothuria leucospilota polysaccharides (HLP‐Ⅰ) was presumed to be roughly as →3)‐β‐d‐GalpNAc‐(1→4)‐β‐d‐GlcpA‐(1→. (2) with T‐Fucp on the branched chain or a rockulose chain consisting of →3,4)‐α‐l‐Fucp‐(1→. (3) HLP‐Ⅰ showed high amorphous platelet content and disordered arrangement, while the molecule adapted a sphere ...
Wanting Wang, Kexue Zhu, Jun Cao, Shunjiang Zeng, Lijun You, Chao Zhao, Yuanping Zheng, Chuan Li   +7 more
wiley   +1 more source

Relationship between Oversulfation and Conformation of Low and High Molecular Weight Fucoidans and Evaluation of Their in Vitro Anticancer Activity

Molecules, 2010
Low and high molecular weight fucoidans (F5-30K and F>30K) were chemically modified through the addition of sulfate groups, and the effect of oversulfation on the in vitro anticancer activity was investigated. After the addition of sulfate groups,
Myoung Lae Cho, Sang Guan You, Boo-Yong Lee   +2 more
doaj   +1 more source

Fucoidan From Brown Algae as a Functional Food Ingredient: A Promising Anticancer Agent

eFood, Volume 6, Issue 4, August 2025.
Fucoidan, a bioactive polysaccharide from brown algae, inhibits receptor tyrosine kinase (RTK) activation and vascular endothelial growth factor (VEGF) signaling, suppressing the phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) and RAS/RAF/mitogen‐activated protein kinase/extracellular signal‐regulated kinase ...
Muhammad Umer Khan, Iqra Khurram, Maha Munir, Muhammad Ikram Ullah, Heba Bassiony Ghanem, Javad Sharifi‐Rad, William N. Setzer, Daniela Calina   +7 more
wiley   +1 more source

Heterofucans from the Brown Seaweed Canistrocarpus cervicornis with Anticoagulant and Antioxidant Activities

Marine Drugs, 2011
Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated L-fucose. We extracted six fucans from Canistrocarpus cervicornis by proteolytic digestion followed by sequential acetone precipitation.
Hugo Alexandre Oliveira Rocha, Sara Lima Cordeiro, Mariana Santana Santos Pereira Costa, Luciana Guimaraes Alves, Nednaldo Dantas-Santos, Gabriel Pereira Fidelis, Leonardo Thiago Duarte Barreto Nobre, Rafael Barros Gomes Camara, Leandro Silva Costa   +8 more
doaj   +1 more source

Phosphate starvation stops bacteria digesting algal fucan that sequesters carbon

AbstractAlgae provide a solar powered pathway to capture and sequester carbon by injecting stable fucan made from carbon dioxide into the ocean1–4. Stability of the pathway is at odds with the presence of marine bacteria with genes of enzymes that can digest fucan and release the carbon dioxide5.
Xu Y, Schultz-Johansen M, Yao H, Wilkie I, Klau LJ, Chen Y, Orellana LH, Aachmann FL, Farhan M, Gu B, Reintjes G, Vidal-Melgosa S, Qiao D, Cao Y, Hehemann J.   +14 more
europepmc   +2 more sources

Simple Extraction and Molecular Weight Characterization of Fucoidan From Indonesian Sargassum SP. [PDF]

, 2013
Fucoidan is a complex polysaccharide compounds found in brown algae. Fucoidan exhibits various biological properties for disease prevention. There are various methods used to extract fucoidan from brown algae, such as using ethanol, acetone, HCl and ...
Junaidi, L. (Lukman)
core   +1 more source

Early growth response protein-1 promoter-mediated synergistic antitumor effect of hTERTC27 gene therapy and 5-flurorouracil on nasopharyngeal carcinoma [PDF]

, 2012
hTERTC27 is a newly constructed polypeptide that can induce telomere dysfunction. To study the synergistic antitumor effects of the hTERTC27 polypeptide driven by the early growth response protein-1 (Egr-1) promoter and chemotherapeutic 5-flurorouracil ...
Chen, S, Lin, G, Lin, MCM, Lin, S, Ng, SSM, Wang, X, Xu, G, Yang, B, Yao, H, Yi, W, Yu, J, Yu, S   +11 more
core   +1 more source

The structure of a family 168 glycoside hydrolase from the marine bacterium Muricauda eckloniae

Acta Crystallographica Section F, Volume 81, Issue 7, Page 281-286, July 2025.
The structure of a putative fucoidan‐degrading glycoside hydrolase assigned to glycoside hydrolase family 168 reveals a (β/α)8 fold. The catalytic machinery and potential substrate specificity were investigated through a structural comparison with a Fun168A oligosaccharide complex.The genome of the marine bacterium Muricauda eckloniae sp.
Emily Knudson-Goerner, Alisdair B. Boraston   +1 more
wiley   +1 more source

Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect [PDF]

Revista Brasileira de Farmacognosia, 2012
Sulfated polysaccharides were extracted with acetone from brown algae Padina gymnospora. The fraction precipitated with 1.5 volumes of acetone (F1.5) purified in Sephadex G-75 was characterized by infrared and nuclear magnetic resonance of 13C and 1H, through which the presence of sulfate groups on the C4 of α-L-fucose could be observed.
Marques, Cybelle Teixeira, Azevedo, Tarciana C. G. de, Nascimento, Marília S., Medeiros, Valquíria P., Alves, Luciana G., Benevides, Norma M. B., Rocha, Hugo A. O., Leite, Edda Lisboa   +7 more
openaire   +3 more sources

Influence of Modified Fucoidan and Related Sulfated Oligosaccharides on Hematopoiesis in Cyclophosphamide-Induced Mice

Marine Drugs, 2018
Immunosuppression derived after cytostatics application in cancer chemotherapy is considered as an adverse side effect that leads to deterioration of quality of life and risk of infectious diseases.
Natalia Yu. Anisimova, Nadezhda E. Ustyuzhanina, Maria I. Bilan, Fedor V. Donenko, Natalia A. Ushakova, Anatolii I. Usov, Mikhail V. Kiselevskiy, Nikolay E. Nifantiev   +7 more
doaj   +1 more source