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Fuchs Endothelial Corneal Dystrophy [PDF]
The Ocular Surface, 2010 Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive loss of corneal endothelial cells, thickening of Descement's membrane and deposition of extracellular matrix in the form of guttae. When the number of endothelial cells becomes critically low, the cornea swells and causes loss of vision. The clinical course of FECD usually spans
Hussain, Elhalis +2 more
exaly +5 more sources
Fuchs endothelial corneal dystrophy: The vicious cycle of Fuchs pathogenesis
Progress in Retinal and Eye Research, 2021 Fuchs endothelial corneal dystrophy (FECD) is the most common primary corneal endothelial dystrophy and the leading indication for corneal transplantation worldwide. FECD is characterized by the progressive decline of corneal endothelial cells (CECs) and the formation of extracellular matrix (ECM) excrescences in Descemet's membrane (DM), called guttae,
Stephan Ong Tone +5 more
openaire +5 more sources
Exploring the histopathological signature of repeat-mediated Fuchs endothelial corneal dystrophy. [PDF]
Acta OphthalmolAbstract Purpose To determine the histological differences between Fuchs endothelial corneal dystrophy (FECD) cases with and without the most common genetic risk factor, expansion of a CTG repeat (CTG18.1) within the TCF4 gene. Methods Formalin‐fixed paraffin‐embedded corneal tissues were compared retrospectively, and CTG18.1 status was determined from
Kladny AS +5 more
europepmc +2 more sources
Changing trends in penetrating keratoplasty indications at a tertiary eye care center in Budapest, Hungary between 2006 and 2017 [PDF]
International Journal of Ophthalmology, 2020 AIM: To analyze the changing trends in penetrating keratoplasty (PKP) indications. METHODS: This retrospective study included all patients with PKP between 2006 and 2017. Patients were classified using histological diagnoses.
Milán Tamás Pluzsik +7 more
doaj +1 more source
Genetic mutations and molecular mechanisms of Fuchs endothelial corneal dystrophy
Eye and Vision, 2021 Background Fuchs endothelial corneal dystrophy is a hereditary disease and the most frequent cause of corneal transplantation in the worldwide. Its main clinical signs are an accelerated decrease in the number of endothelial cells, thickening of Descemet’
Xuerui Liu +6 more
doaj +1 more source
Fuchs Endothelial Corneal Dystrophy [PDF]
JAMA Ophthalmology, 2014 First described more than a century ago, Fuchs endothelial corneal dystrophy (FECD) is a common disease characterized by progressive loss of endothelial cells, thickening of the Descemet membrane, and deposition of extracellular matrix in the form of guttae.
Angela Y, Zhu +2 more
openaire +2 more sources
Frontiers in Medicine, 2021 Background: Our study aimed to determine the correlation between the clinical staging of Fuchs' endothelial corneal dystrophy (FECD), rate of endothelial cell loss, and corneal biomechanical properties.Methods: This study combined a longitudinal ...
Usanee Reinprayoon +4 more
doaj +1 more source
Long-Term Results after DMEK (Descemet’s Membrane Endothelial Keratoplasty) [PDF]
, 2020 Ziel der Arbeit: Evaluation der langfristigen Ergebnisse sowie der Komplikationsrate nach Descemet’s Membran Endothelialen Keratoplastik (DMEK) Methoden: Eine cross-sectional, Fall-Serien Studie.
Wardeh, Rima
core +1 more source
The comorbidity of keratoconus and Fuchs’ endothelial corneal dystrophy (clinical cases)
Офтальмохирургия, 2021 Purpose. To describe the clinical cases and surgery results in patients with concomitant of keratoconus and Fuchs’ corneal endothelial dystrophy. Material and methods. Retrospective analysis of 3 patients using different surgical techniques. All patients
B. E. Malyugin +2 more
doaj +1 more source
Peroxiredoxin-1 regulates lipid peroxidation in corneal endothelial cells
Redox Biology, 2020 Corneal transparency is maintained by a monolayer of corneal endothelial cells. Defects in corneal endothelial cells (CEnCs) can be rectified surgically through transplantation.
Matthew Lovatt +5 more
doaj +1 more source