Results 51 to 60 of about 609,036 (191)

Early oxidation‐related changes in aqueous humor following eye exposure to ultraviolet‐A radiation

Photochemistry and Photobiology, EarlyView.
UVA exposure induces early oxidative alterations in the aqueous humor, disrupting its antioxidant balance. Levels of ascorbic acid, reduced glutathione (GSH), and the GSH/GSSG ratio decrease, while oxidized glutathione (GSSG), S‐glutathionylated proteins (PSSG), and malondialdehyde (MDA), a lipid peroxidation by‐product, increase.
Corinne Zinflou, Patrick J. Rochette
wiley   +1 more source

Update on the genetics of corneal endothelial dystrophies

Indian Journal of Ophthalmology, 2022
Corneal endothelial dystrophies are a heterogeneous group of diseases with different modes of inheritance and genetic basis for each dystrophy. The genes associated with these diseases encode transcription factors, structural components of the stroma and
Chitra Kannabiran, Sunita Chaurasia, Muralidhar Ramappa, Venkateswara Vinod Mootha   +3 more
doaj   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, Volume 11, Issue 20, 21 October 2026.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Immunohistochemical Profiling of Corneas With Fuchs Endothelial Corneal Dystrophy [PDF]

Cornea, 2017
Purpose: Fuchs endothelial corneal dystrophy (FECD) is the leading indication for endothelial keratoplasty. Further insight into its pathophysiology is needed to develop alternative therapies. Methods: Sixteen genes from a previous microarray expression experiment (FECD vs.
De Roo, An-Katrien, Janssens, Thomas, Foets, Beatrijs, van den Oord, Joost   +3 more
openaire   +2 more sources

Bilateral corneal edema in an alcoholic male

Taiwan Journal of Ophthalmology, 2021
Pseudophakic bullous keratopathy and Fuchs' endothelial dystrophy are the two most common causes of corneal edema after cataract surgery. We report a 61-year-old alcoholic male with bilateral corneal edema that improved after his alcohol abstinence.
Peng-Yu Lee, Wei-Yi Chou, Chih-Chien Hsu, Pei-Yu Lin, Ko-Hua Chen   +4 more
doaj   +1 more source

Genetic Therapy of Fuchs Endothelial Corneal Dystrophy: Where Are We? A Review. [PDF]

Genes (Basel)
Objectives: The incidence of Fuchs endothelial corneal dystrophy (FECD) is growing, and with it, the unmet need for a corneal transplant. Among alternative treatment modalities, only genetic therapy represents a causal therapy.
Stunf Pukl S.
europepmc   +2 more sources

Hyaluronan in Ocular Surface Health and Disease: From Biological Mechanisms to Therapeutic Applications

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT Hyaluronan (HA) is an ubiquitous non‐sulfated glycosaminoglycan with unique physicochemical and biological properties that underpin its essential roles in tissue homeostasis, repair, and diseases. First identified in the vitreous humor of the eye, HA has a long‐standing history in ophthalmology as a key component of ophthalmic visco‐surgical ...
Sudhir Verma, Mohammed Salman, Eduardo Cilli, Vivien Coulson‐Thomas   +3 more
wiley   +1 more source

Fuchs endothelial corneal dystrophy and corneal endothelial diseases: East meets West [PDF]

Eye, 2019
Fuchs endothelial corneal dystrophy (FECD) is amongst one of the most common indications for endothelial keratoplasty worldwide. Despite being originally described among Caucasians, it is now known to be prevalent among a large number of populations, including Asians.
Y Q, Soh, Viridiana, Kocaba, Mauricio, Pinto, Jodhbir S, Mehta   +3 more
openaire   +2 more sources

Patterns and frequency of keratoplasty in corneal dystrophy at a tertiary eye hospital in Nepal

BMC Ophthalmology
Background Corneal dystrophy is a group of hereditary disorders with different presentations and management between regions and ethnic groups. This study aimed to report the patterns of corneal dystrophy, the frequency of keratoplasty requirement, and ...
Rachana Singh Rana, Tithsya Hun, Manish P. Poudel   +2 more
doaj   +1 more source

Whole Exome Sequencing Identified a Novel Mutation in the LOXHD1 Gene in Consanguineous Iranian Families With Hearing Loss

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
Whole exome sequencing in a consanguineous Iranian family with autosomal recessive non‐syndromic hearing loss revealed a novel homozygous frameshift mutation, c.3713dupA (p.Asp1238Glufs*10), in the LOXHD1 gene. This mutation, located in exon 24, results in a premature stop codon and a truncated protein. Sanger sequencing confirmed co‐segregation of the
Solmaz Hassani Fard Katiraei, Milad Gholami, Mohsen Soosanabadi, Mona Entezam, Seyed Alireza Dastgheib   +4 more
wiley   +1 more source