Results 41 to 50 of about 6,352 (223)

Sustained activation of the unfolded protein response induces cell death in Fuchs' endothelial corneal dystrophy [PDF]

, 2017
Purpose: The unfolded protein response (UPR) is believed to play a role in the pathogenesis of Fuchs' endothelial corneal dystrophy (FECD). The purpose of this study was to investigate whether unfolded proteins accumulate in the corneal endothelium in ...
Hashimoto, Keisuke, Kinoshita, Shigeru, Kitahara, Miu, Koizumi, Noriko, Kruse, Friedrich, Nakahara, Makiko, Okuda, Hirokazu, Okumura, Naoki, Quantock, Andrew J., Schlötzer-Schrehardt, Ursula, Tourtas, Theofilos, Ueda, Emi, Young, Robert D.   +12 more
core   +1 more source

Corneal clearance and central endothelial cell repopulation despite graft detachment after Descemet membrane endothelial keratoplasty

GMS Ophthalmology Cases, 2019
Objective: Descemet membrane endothelial keratoplasty (DMEK) is the gold standard procedure for treatment of primary corneal endothelial disorders. Graft detachment is a frequent complication of DMEK, which often requires re-operation or re-bubbling ...
Daravagka, Maria, Nestler, Andrei, Wiedemann, Peter, Girbardt, Christian   +3 more
doaj   +1 more source

Phototherapeutic keratectomy for anterior stromal fibrosis following DMEK

American Journal of Ophthalmology Case Reports, 2020
Purpose: Anterior stromal fibrosis is often seen in advanced cases of Fuchs endothelial dystrophy or secondary endothelial insufficiency. As Descemet membrane endothelial keratoplasty (DMEK) can completely eliminate the corneal edema and the guttae in ...
Philip Maier, Thomas Reinhard
doaj   +1 more source

Phenotypic and functional characterization of corneal endothelial cells during in vitro expansion. [PDF]

, 2020
The advent of cell culture-based methods for the establishment and expansion of human corneal endothelial cells (CEnC) has provided a source of transplantable corneal endothelium, with a significant potential to challenge the one donor-one recipient ...
Aldave, Anthony J, Azimov, Rustam, Boere, Payton M, Chung, Doug D, Frausto, Ricardo F, George, Benjamin L, Hanser, E Maryam, Kao, Liyo, Kurtz, Ira, Mehta, Jodhbir S, Morselli, Marco, Peh, Gary SL, Pellegrini, Matteo, Swamy, Vinay S, Wu, Jessica   +14 more
core  

Corneal Hydration Control in Fuchs' Endothelial Corneal Dystrophy

Investigative Opthalmology & Visual Science, 2016
To assess corneal hydration control across a range of severity of Fuchs' endothelial corneal dystrophy (FECD) by measuring the percent recovery per hour (PRPH) of central corneal thickness after swelling the cornea and to determine its association with corneal morphologic parameters.Twenty-three corneas of 23 phakic FECD patients and 8 corneas of 8 ...
Wacker, Katrin, McLaren, Jay W., Kane, Katrina M., Baratz, Keith H., Patel, Sanjay V.   +4 more
openaire   +3 more sources

Automated detection and classification of nuclei in immunohistochemical stainings for Fuchs' endothelial corneal dystrophy [PDF]

, 2006
Fuchs’ endothelial corneal dystrophy (FECD) is a degenerative disease that affects the elderly population, and which lacks a unifying pathogenic theory and tangible drug targets.
Janssens, Thomas, De Roo, An-Katrien, Foets, Beatrijs, van den Oord, Joost, Van den Berghe, Greet, Güiza, Fabian   +5 more
core   +2 more sources

SLC4A11 depletion impairs NRF2 mediated antioxidant signaling and increases reactive oxygen species in human corneal endothelial cells during oxidative stress

Scientific Reports, 2017
Corneal endothelial dystrophy is a progressive disease with gradual loss of vision and characterized by degeneration and dysfunction of corneal endothelial cells.
Sanjukta Guha, Sunita Chaurasia, Charanya Ramachandran, Sanhita Roy   +3 more
doaj   +1 more source

Fuchs Endothelial Corneal Dystrophy-Specific Questionnaire in Croatian: Visual Function and Corneal Health Status (V-FUCHS)

Acta Clinica Croatica
Fuchs endothelial corneal dystrophy (FECD) is a bilateral dystrophy of the cornea and the most common indication for corneal transplantation procedures.
Ivan Merdžo, Ivana Radman, Aida Kasumović, Miodrag Vojčić, Antonio Markotić, Nina Đumrukčić, Iva Krolo   +6 more
doaj   +1 more source

Comparative analysis of ultrasound and femtolaser-assisted phacoemulsification in patients with primary endothelial Fuchs corneal dystrophy

Офтальмохирургия, 2021
Purpose. To highlight the comparative results of surgical treatment of patients with primary Fuchs’ endothelial corneal dystrophy (FECD) using the methods of classical ultrasonic phacoemulsification and femtolaser-assisted phacoemulsification of cataract.
B. E. Malyugin, O. P. Antonova, G. A. Umbetalieva, Z. R. Ebzeeva   +3 more
doaj   +1 more source

Exploring the histopathological signature of repeat‐mediated Fuchs endothelial corneal dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the histological differences between Fuchs endothelial corneal dystrophy (FECD) cases with and without the most common genetic risk factor, expansion of a CTG repeat (CTG18.1) within the TCF4 gene. Methods Formalin‐fixed paraffin‐embedded corneal tissues were compared retrospectively, and CTG18.1 status was determined from
Anne‐Marie S. Kladny, Nihar Bhattacharyya, Marcos Abreu Costa, Stephen J. Tuft, Caroline Thaung, Alice E. Davidson   +5 more
wiley   +1 more source