Results 51 to 60 of about 6,427 (219)

Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy

Nature Communications, 2017
Fuchs endothelial corneal dystrophy (FECD) is one of the most common reasons for corneal transplantation, and is known to cluster in families. Here, the authors discover new genetic loci associated with FECD with sex-specific effects and implications for
Natalie A. Afshari, Robert P. Igo, Nathan J. Morris, Dwight Stambolian, Shiwani Sharma, V. Lakshmi Pulagam, Steven Dunn, John F. Stamler, Barbara J. Truitt, Jacqueline Rimmler, Abraham Kuot, Christopher R. Croasdale, Xuejun Qin, Kathryn P. Burdon, S. Amer Riazuddin, Richard Mills, Sonja Klebe, Mollie A. Minear, Jiagang Zhao, Elmer Balajonda, George O. Rosenwasser, Keith H Baratz, V. Vinod Mootha, Sanjay V. Patel, Simon G. Gregory, Joan E. Bailey-Wilson, Marianne O. Price, Francis W. Price, Jamie E. Craig, John H. Fingert, John D. Gottsch, Anthony J. Aldave, Gordon K. Klintworth, Jonathan H. Lass, Yi-Ju Li, Sudha K. Iyengar   +35 more
doaj   +1 more source

Comparative analysis of ultrasound and femtolaser-assisted phacoemulsification in patients with primary endothelial Fuchs corneal dystrophy

Офтальмохирургия, 2021
Purpose. To highlight the comparative results of surgical treatment of patients with primary Fuchs’ endothelial corneal dystrophy (FECD) using the methods of classical ultrasonic phacoemulsification and femtolaser-assisted phacoemulsification of cataract.
B. E. Malyugin, O. P. Antonova, G. A. Umbetalieva, Z. R. Ebzeeva   +3 more
doaj   +1 more source

Endothelial dysfunction in a child with Pearson marrow-pancreas syndrome managed with Descemet stripping automated endothelial keratoplasty using a suture pull-through techniqu [PDF]

, 2019
A 4-year-old girl with a history of Pearson marrow-pancreas syndrome presenting with severe, progressive photophobia was found to have bilateral, diffuse corneal thickening and peripheral pigmentary retinopathy. She underwent Descemet stripping automated
Areaux, Raymond G., Jr., Berry, Susan, Halbach, Caroline S., Hou, Joshua H., Vadhul, Raghav   +4 more
core   +1 more source

Sustained activation of the unfolded protein response induces cell death in Fuchs' endothelial corneal dystrophy [PDF]

, 2017
Purpose: The unfolded protein response (UPR) is believed to play a role in the pathogenesis of Fuchs' endothelial corneal dystrophy (FECD). The purpose of this study was to investigate whether unfolded proteins accumulate in the corneal endothelium in ...
Hashimoto, Keisuke, Kinoshita, Shigeru, Kitahara, Miu, Koizumi, Noriko, Kruse, Friedrich, Nakahara, Makiko, Okuda, Hirokazu, Okumura, Naoki, Quantock, Andrew J., Schlötzer-Schrehardt, Ursula, Tourtas, Theofilos, Ueda, Emi, Young, Robert D.   +12 more
core   +1 more source

Tissue‐level heterogeneity in FECD: Descemet's membrane phenotypes and association with TCF4 CTG18.1 expansion†

The Journal of Pathology, EarlyView.
Abstract Late‐onset Fuchs endothelial corneal dystrophy (FECD) is commonly framed as a corneal endothelial disease characterised by guttae accumulation and progressive thickening of Descemet's membrane (DM). However, clinical forms and evolutionary profiles vary widely.
Sayo Maeno, Yoshinori Oie, Chifune Kai, Kohji Nishida   +3 more
wiley   +1 more source

Bilateral corneal edema in an alcoholic male

Taiwan Journal of Ophthalmology, 2021
Pseudophakic bullous keratopathy and Fuchs' endothelial dystrophy are the two most common causes of corneal edema after cataract surgery. We report a 61-year-old alcoholic male with bilateral corneal edema that improved after his alcohol abstinence.
Peng-Yu Lee, Wei-Yi Chou, Chih-Chien Hsu, Pei-Yu Lin, Ko-Hua Chen   +4 more
doaj   +1 more source

Mini descemet membrane stripping (m-DMES) in patients with Fuchs' endothelial dystrophy: A new method. [PDF]

, 2017
We present two cases with focal corneal edema due to Fuchs' endothelial dystrophy that were successfully treated with mini Descemet membrane stripping (m-DMES) (diameter of 3-4 mm; at the area of preexisting focal corneal edema) without endothelial ...
Grentzelos, M.A., Kontadakis, G.A., Kymionis, G.D., Liakopoulos, D.A., Naoumidi, I., Petrelli, M.K., Tsoulnaras, K.I.   +6 more
core   +2 more sources

Astigmatic changes after Descemet membrane endothelial keratoplasty (DMEK) in decompensated penetrating keratoplasty grafts

Acta Ophthalmologica, EarlyView.
Abstract Purpose To evaluate the surgery‐induced changes of astigmatism after Descemet membrane endothelial keratoplasty (DMEK) in eyes with failed previous penetrating keratoplasty (PK). Design Retrospective, interventional cohort study based on prospective DMEK database.
Florian Thomas Steinberg, Jithmi Weliwitage, Marie von Berg, Silvia Schrittenlocher, Simona Schlereth, Claus Cursiefen, Björn Bachmann   +6 more
wiley   +1 more source

Fuchs Endothelial Corneal Dystrophy in Patients With Myotonic Dystrophy [PDF]

Cornea, 2014
The aim was to report 4 cases of Fuchs endothelial corneal dystrophy (FECD) in patients with an established diagnosis of myotonic dystrophy (DM) and suggest a mechanism for their association based on the known molecular genetics and potential pathophysiological parallels of DM and FECD.We reviewed all available medical records and pathology slides for ...
Devin, Gattey, Angela Y, Zhu, Anna, Stagner, Mark A, Terry, Albert S, Jun   +4 more
openaire   +2 more sources

Descemet membrane endothelial keratoplasty combined with secondary sulcus hydrophobic intraocular lens implantation

American Journal of Ophthalmology Case Reports
Purpose: To report a case of combined Descemet membrane endothelial keratoplasty (DMEK) and secondary sulcus hydrophobic intraocular lens (IOL) implantation for hyperopic correction in a pseudophakic eye with Fuchs’ endothelial corneal dystrophy ...
Colya N. Englisch, Philip Wakili, Clara E. Englisch, Karl T. Boden, Annekatrin Rickmann, Peter Szurman, André Messias   +6 more
doaj   +1 more source