Langerin-Heparin Interaction: Two Binding Sites for Small and Large Ligands as revealed by a combination of NMR Spectroscopy and Cross-Linking Mapping Experiments [PDF]
, 2015 Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent internalization and elimination in the cellular organelles called Birbeck granules.
Angulo, Jesus +9 more
core +7 more sources
Materials of marine origin: a review on polymers and ceramics of biomedical interest [PDF]
, 2012 Marine organisms are constituted by materials with a vast range of properties and characteristics that may justify their potential application within the biomedical field.
Alves, A. +9 more
core +1 more source
N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens [PDF]
, 2015 BACKGROUND: The temporary or long-term xenotransplantation of pig organs into people would save thousands of lives each year if not for the robust human antibody response to pig carbohydrates.
Bern, Marshall +7 more
core +1 more source
Fucosylated Chondroitin Sulfates from the Body Wall of the Sea Cucumber Holothuria forskali [PDF]
Journal of Biological Chemistry, 2014 Fucosylated chondroitin sulfate (fCS) extracted from the sea cucumber Holothuria forskali is composed of the following repeating trisaccharide unit: -> 3)GalNAc beta 4,6S(1 -> 4) [Fuc alpha X(1 -> 3)]GlcA beta(1 ->, where X stands for different sulfation patterns of fucose (X = 3,4S (46%), 2,4S (39%), and 4S (15%)).
Panagos, Charalampos G. +14 more
openaire +1 more source
Antioxidant Potential of Sea Cucumbers and Their Beneficial Effects on Human Health
Marine Drugs, 2022 Sea cucumbers are considered a luxury food item and used locally in traditional medication due to their impressive nutritional profile and curative effects.
Abul Hossain +2 more
doaj +1 more source
Marine Drugs, 2015 Anionic polysaccharides fucosylated chondroitin sulfates (FCS) from holothurian species were shown to affect various biological processes, such as metastasis, angiogenesis, clot formation, thrombosis, inflammation, and some others.
Alexey G. Gerbst +3 more
doaj +1 more source
A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation [PDF]
, 2016 Glycosylation greatly influences the safety and efficacy of many of the highest-selling recombinant therapeutic proteins (rTPs). In order to define optimal cell culture feeding strategies that control rTP glycosylation, it is necessary to know how ...
Jimenez del Val, I +2 more
core +1 more source
Marine Drugs, 2023 Sulfated glycans from marine organisms are excellent sources of naturally occurring glycosaminoglycan (GAG) mimetics that demonstrate therapeutic activities, such as antiviral/microbial infection, anticoagulant, anticancer, and anti-inflammation ...
Peng He +10 more
doaj +1 more source
Quantitative N-glycoproteomics reveals altered glycosylation levels of various plasma proteins in bloodstream infected patients [PDF]
, 2018 Bloodstream infections are associated with high morbidity and mortality with rates varying from 10–25% and higher. Appropriate and timely onset of antibiotic therapy influences the prognosis of these patients. It requires the diagnostic accuracy which is
Agarwal, Rahul +7 more
core +2 more sources
Advanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.A multilayered small‐caliber vascular scaffold combining electrospinning and 4‐axis printing is developed and biofunctionalized with marine sulfated polysaccharides from Holothuria tubulosa. The resulting construct exhibits enhanced hemocompatibility, tunable mechanical properties, and supports endothelial and smooth muscle cell adhesion and ...
Gabriele Obino +9 more
wiley +1 more source