Results 71 to 80 of about 1,579 (190)
Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation [PDF]
, 2019 Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all mammalian cells and usually covalently attached to proteins, forming proteoglycans.
Morla, Shravan
core +1 more source
Sulfatases: Catalytic Mechanism, Substrate Preferences, and Carbohydrate‐Based Inhibitor Design
Israel Journal of Chemistry, Volume 65, Issue 12, December 2025.Sulfatases are a class of enzymes that can cleave sulfates from heparan sulfate and modulate many of their biological activities. In this review, following a general introduction on sulfatase, their enzymatic mechanism and substrate scope are discussed.
Morgan Mayieka +3 more
wiley +1 more source
Heparin: New life for an old drug [PDF]
, 2023 © 2017 Future Medicine Ltd. Heparin is one of the oldest drugs, which nevertheless remains in widespread clinical use as an inhibitor of blood coagulation.
Aláez Versón, Carlos Raúl +2 more
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Glycan Engineering for Cell and Developmental Biology [PDF]
, 2016 Cell-surface glycans are a diverse class of macromolecules that participate in many key biological processes, including cell-cell communication, development, and disease progression.
Griffin, Matthew E. +1 more
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Non-Anticoagulant Heparan Sulfate from the Ascidian Phallusia nigra Prevents Colon Carcinoma Metastasis in Mice by Disrupting Platelet-Tumor Cell Interaction [PDF]
, 2020 Although metastasis is the primary cause of death in patients with malignant solid tumors, efficient anti-metastatic therapies are not clinically available currently.
Borsig, Lubor +7 more
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The FASEB Journal, Volume 39, Issue 20, 31 October 2025.Graphical summary of glycosylation impairments in various neurodegenerative disorders. Among the diverse forms of glycosylation, the most extensively studied include N‐glycosylation, O‐glycosylation, and O‐GlcNAcylation. Aberrant glycosylation has been implicated in multiple neurodegenerative conditions.
Haihan Yu +5 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2014 In this review, several glycosaminoglycan analogs obtained from different marine invertebrate are reported. The structure, biological activity and mechanism of action of these unique molecules are detailed reviewed and exemplified by experiments in vitro
Mauro Sergio Pavao
doaj +1 more source
Antitumor properties of a new non-anticoagulant heparin analog from the mollusk Nodipecten nodosus: Effect on P-selectin, heparanase, metastasis and cellular recruitment [PDF]
, 2017 Inflammation and cancer are related pathologies acting synergistically to promote tumor progression. In both, hematogenous metastasis and inflammation, P-selectin participates in interactions involving tumor cells, platelets, leukocytes and endothelium ...
Borsig, Lubor +5 more
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Food Biomacromolecules, Volume 2, Issue 3, Page 288-314, September 2025.Abstract Metabolic syndrome (MetS) is a complex noncommunicable condition characterized by central obesity, insulin resistance, hyperlipidemia, hypertension, and hyperglycemia. Epidemiological evidence shows that MetS affects a third of the global population; however, due to its complex pathogenesis and limited drug therapy options, the increasing ...
Josiah Owuor Oyalo +3 more
wiley +1 more source
eFood, Volume 6, Issue 4, August 2025.(1) The main chain structure of Holothuria leucospilota polysaccharides (HLP‐Ⅰ) was presumed to be roughly as →3)‐β‐d‐GalpNAc‐(1→4)‐β‐d‐GlcpA‐(1→. (2) with T‐Fucp on the branched chain or a rockulose chain consisting of →3,4)‐α‐l‐Fucp‐(1→. (3) HLP‐Ⅰ showed high amorphous platelet content and disordered arrangement, while the molecule adapted a sphere ...
Wanting Wang +7 more
wiley +1 more source