Results 31 to 40 of about 5,550 (234)

Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach. [PDF]

PLoS ONE, 2012
Owing to its aggressiveness and the lack of effective therapies, pancreatic ductal adenocarcinoma has a dismal prognosis. New strategies to improve treatment and survival are therefore urgently required.
Makoto Yoshida, Rishu Takimoto, Kazuyuki Murase, Yasushi Sato, Masahiro Hirakawa, Fumito Tamura, Tsutomu Sato, Satoshi Iyama, Takahiro Osuga, Koji Miyanishi, Kohichi Takada, Tsuyoshi Hayashi, Masayoshi Kobune, Junji Kato   +13 more
doaj   +1 more source

The in vivo transcriptome of Schistosoma mansoni in the prominent vector species Biomphalaria pfeifferi with supporting observations from Biomphalaria glabrata. [PDF]

, 2019
BackgroundThe full scope of the genes expressed by schistosomes during intramolluscan development has yet to be characterized. Understanding the gene products deployed by larval schistosomes in their snail hosts will provide insights into their ...
Bu, Lijing, Buddenborg, Sarah K, Hanelt, Ben, Kamel, Bishoy, Loker, Eric S, Mkoji, Gerald M, Zhang, Si-Ming   +6 more
core   +2 more sources

In silico analysis of the fucosylation-associated genome of the human blood fluke Schistosoma mansoni: cloning and characterization of the fucosyltransferase multigene family.

PLoS ONE, 2013
Fucosylated glycans of the parasitic flatworm Schistosoma mansoni play key roles in its development and immunobiology. In the present study we used a genome-wide homology-based bioinformatics approach to search for genes that contribute to fucosylated ...
Nathan A Peterson, Tavis K Anderson, Timothy P Yoshino   +2 more
doaj   +1 more source

FUCA2 and TSTA3 expression in gastric cancer: candidate biomarkers of malignant transformation

Folia Histochemica et Cytobiologica, 2022
INTRODUCTION: Aberrant fucosylation is closely related to malignant transformation, cancer detection, and evaluation of treatment efficacy. The fucosylation process requires GDP-L-fucose, fucosyltransferases, and fucosidases.
Michael Williames Leal Quirino, Amanda Pinheiro de Barros Albuquerque, Maria de Fátima Deodato de Souza, Antônio Felix da Silva Filho, Mário Rino Martins, Maira Galdino da Rocha Pitta, Michelly Cristiny Pereira, Moacyr Jesus Barreto de Melo   +7 more
doaj   +1 more source

Carcinoma-associated fucosylated antigens are markers of the epithelial state and can contribute to cell adhesion through CLEC17A (Prolectin) [PDF]

, 2016
International audienceTerminal fucosylated motifs of glycoproteins and glycolipid chains are often altered in cancer cells. We investigated the link between fucosylation changes and critical steps in cancer progression: epithelial-to-mesenchymal ...
Altare, F, Barille-Nion, S, Bernardeau, K, Breiman, A, Drickamer, K, Echasserieau, K, Imberty, A, Le Pendu, J, Robles, MDL, Trecesson, SDC   +9 more
core   +5 more sources

Subcellular localisation of cerebral fucosyltransferase [PDF]

FEBS Letters, 1984
GDP‐fucose : asialofetuin fucosyltransferase from sheep brain was fractionated on a sucrose gradient into two activity peaks. Using purification on Ficoll adapted from the proposed method [(1980) J. Neurochem. 35, 281‐296], double localisation of cerebral fucosyltransferase was confirmed and the subcellular active fractions identified as light ...
Broquet, P., Serres-Guillaumond, M., Baubichon-Cortay, H., Peschard, Mj, Louisot, P.   +4 more
openaire   +3 more sources

Anaplasma marginale Infection of Dermacentor andersoni Primary Midgut Cell Culture Is Dependent on Fucosylated Glycans

Frontiers in Cellular and Infection Microbiology, 2022
Tick midgut is the primary infection site required by tick-borne pathogens to initiate their development for transmission. Despite the biological significance of this organ, cell cultures derived exclusively from tick midgut tissues are unavailable and ...
Rubikah Vimonish, Janaina Capelli-Peixoto, Wendell C. Johnson, Hala E. Hussein, Hala E. Hussein, Naomi S. Taus, Kelly A. Brayton, Ulrike G. Munderloh, Susan M. Noh, Susan M. Noh, Massaro W. Ueti, Massaro W. Ueti, Massaro W. Ueti   +12 more
doaj   +1 more source

Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding [PDF]

, 2007
Fertilization depends on successful binding of the spermatozoa to the zona pellucida of the oocyte. Glycodelin-A inhibits spermatozoa-zona pellucida binding.
Chiu, PCN, Chung, MK, Ho, PC, Koistinen, H, Koistinen, R, Lee, KF, Ng, EHY, Seppala, M, Yeung, WSB   +8 more
core   +1 more source

Recent Progress on Fucosyltransferase Inhibitors

Mini-Reviews in Medicinal Chemistry, 2012
Fucosyltransferases (FucTs) are enzymes that transfer L-fucose from GDP-fucose to a glycoside or a peptide. They have important roles in a variety of diseases including cancer and autoimmune disorders, viral and bacterial infections and inflammatory processes, and thus they represent important drug targets for the development of agents for the ...
Merino, Pedro, Tejero, Tomás, Delso, J. Ignacio, Hurtado-Guerrero, Ramón, Gómez-SanJuan, Asier, Sádaba, David   +5 more
openaire   +3 more sources

Stage‐specific expression of α1,2‐fucosyltransferase and α1,3‐fucosyltransferase (FT) during mouse embryogenesis [PDF]

European Journal of Biochemistry, 1999
Lex[Galβ1–4(Fucα1–3)GlcNAc] and Ley[Fucα1–2Galβ1–4(Fucα1–3)GlcNAc] are both stage‐specific embryonic antigens. Lex is first detected on the blastomeres of the 8‐cell stage embryo, which correlates with the onset of blastomere compaction. Ley is highly expressed on the surface of the blastocyst, which has been shown to be involved in blastocyst ...
N, Liu, C, Jin, Z M, Zhu, J, Zhang, H, Tao, C, Ge, S, Yang, S, Zhang   +7 more
openaire   +3 more sources