Results 31 to 40 of about 5,422 (250)

Stage‐specific expression of α1,2‐fucosyltransferase and α1,3‐fucosyltransferase (FT) during mouse embryogenesis [PDF]

European Journal of Biochemistry, 1999
Lex[Galβ1–4(Fucα1–3)GlcNAc] and Ley[Fucα1–2Galβ1–4(Fucα1–3)GlcNAc] are both stage‐specific embryonic antigens. Lex is first detected on the blastomeres of the 8‐cell stage embryo, which correlates with the onset of blastomere compaction. Ley is highly expressed on the surface of the blastocyst, which has been shown to be involved in blastocyst ...
Changhui Ge, Hua Tao, Ni Liu, Jianing Zhang, Cheng Jin, Shoujun Yang, Zheng M. Zhu, Shuzheng Zhang   +7 more
openaire   +3 more sources

Fucosyltransferases Regulated by Fusobacterium Nucleatum and Act as Novel Biomarkers in Colon Adenocarcinoma

Journal of Inflammation Research, 2023
Pengfei Wang,1,2,* Xuxu Liu,1,2,* Jingjing Yu,1,2 Ziang Meng,1,2 Zhenyi Lv,1,2 Ce Shang,1,2 Qi Geng,1,2 Dawei Wang,1,2 Dongbo Xue,1,2 Long Li3 1Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin ...
Wang P, Liu X, Yu J, Meng Z, Lv Z, Shang C, Geng Q, Wang D, Xue D, Li L   +9 more
doaj  

Post-Synthetic Defucosylation of AGP by Aspergillus nidulans α-1,2-Fucosidase Expressed in Arabidopsis Apoplast Induces Compensatory Upregulation of α-1,2-Fucosyltransferases. [PDF]

PLoS ONE, 2016
Cell walls are essential components of plant cells which perform a variety of important functions for the different cell types, tissues and organs of a plant.
Gennady V Pogorelko, Nathan T Reem, Zachary T Young, Lauran Chambers, Olga A Zabotina   +4 more
doaj   +1 more source

Recent Progress on Fucosyltransferase Inhibitors

Mini-Reviews in Medicinal Chemistry, 2012
Fucosyltransferases (FucTs) are enzymes that transfer L-fucose from GDP-fucose to a glycoside or a peptide. They have important roles in a variety of diseases including cancer and autoimmune disorders, viral and bacterial infections and inflammatory processes, and thus they represent important drug targets for the development of agents for the ...
Merino, Pedro, Tejero, Tomás, Delso, J. Ignacio, Hurtado-Guerrero, Ramón, Gómez-SanJuan, Asier, Sádaba, David   +5 more
openaire   +4 more sources

Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling

Cell Death and Disease, 2021
Glycosylation is an important modification of membrane proteins that results in functional changes in many cellular activities, from cell-cell recognition to regulatory signaling.
Shanyi Lin, Lenian Zhou, Yang Dong, Qingcheng Yang, Quanjun Yang, Hanqiang Jin, Ting Yuan, Shumin Zhou   +7 more
doaj   +1 more source

Human fucosyltransferase 6 enables prostate cancer metastasis to bone [PDF]

, 2014
Background: The interaction between human prostate cancer (PCa) cells and bone marrow (BM) endothelium follows a rolling-and-adhesion cascade mediated by E-selectin ligand (ESL): E-selectin.
Barthel, S R, Dimitroff, C J, Guillebon, A D, Hsu, J-w, King, M R, Lee, Y-F, Li, J   +6 more
core   +1 more source

GDP-fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP-fucose and fucosylated glycan synthesis. [PDF]

FEBS Open Bio
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Skurska E, Olczak M.
europepmc   +2 more sources

Anaplasma marginale Infection of Dermacentor andersoni Primary Midgut Cell Culture Is Dependent on Fucosylated Glycans

Frontiers in Cellular and Infection Microbiology, 2022
Tick midgut is the primary infection site required by tick-borne pathogens to initiate their development for transmission. Despite the biological significance of this organ, cell cultures derived exclusively from tick midgut tissues are unavailable and ...
Rubikah Vimonish, Janaina Capelli-Peixoto, Wendell C. Johnson, Hala E. Hussein, Hala E. Hussein, Naomi S. Taus, Kelly A. Brayton, Ulrike G. Munderloh, Susan M. Noh, Susan M. Noh, Massaro W. Ueti, Massaro W. Ueti, Massaro W. Ueti   +12 more
doaj   +1 more source

Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding [PDF]

, 2007
Fertilization depends on successful binding of the spermatozoa to the zona pellucida of the oocyte. Glycodelin-A inhibits spermatozoa-zona pellucida binding.
Chiu, PCN, Chung, MK, Ho, PC, Koistinen, H, Koistinen, R, Lee, KF, Ng, EHY, Seppala, M, Yeung, WSB   +8 more
core   +1 more source

Characterizing human α-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases [PDF]

Journal of Biological Chemistry, 2020
Mammalian Asn-linked glycans are extensively processed as they transit the secretory pathway to generate diverse glycans on cell surface and secreted glycoproteins. Additional modification of the glycan core by α-1,6-fucose addition to the innermost GlcNAc residue (core fucosylation) is catalyzed by an α-1,6-fucosyltransferase (FUT8). The importance of
Zachary A. Wood, Gerlof P. Bosman, Renuka Kadirvelraj, Lai-Xi Wang, Jeong-Yeh Yang, Lin Liu, Kelley W. Moremen, Chao Li, Guanghui Zong, Bhargavi M. Boruah, Annapoorani Ramiah, Geert-Jan Boons, Geert-Jan Boons   +12 more
openaire   +4 more sources