Results 61 to 70 of about 5,550 (234)

Naïve T cells re-distribute to the lungs of selectin ligand deficient mice. [PDF]

PLoS ONE, 2010
Selectin mediated tethering represents one of the earliest steps in T cell extravasation into lymph nodes via high endothelial venules and is dependent on the biosynthesis of sialyl Lewis X (sLe(x)) ligands by several glycosyltransferases, including two ...
John R Harp, Thandi M Onami
doaj   +1 more source

Characterization of Fut10 and Fut11, Putative Alpha-1-3/4 Fucosyltransferase Genes Important for Vertebrate Development [PDF]

, 2007
Two new, putative alpha-1-3/4 fucosyltransferases ([alpha]1-3/4 Fuc-Ts), Fuc-TX and Fuc-TXI, were identified in the vertebrate genome and transcriptome sequence databases through sequence homology-based queries. These proteins have a significant sequence
Santosh K. Patnaik
core   +1 more source

Efficient Biosynthesis of 2’-Fucosyllactose Using Glycerol and Lactose in Engineered Escherichia coli [PDF]

Shipin Kexue
In this study, the de novo synthesis pathway of 2’-FL was established in Escherichia coli BL21star(DE3). The β-galactosidase gene (lacZ) and the UDP-glucose lipid carrier transferase gene (wcaJ) were knocked out by the CRISPR/Cas9 system.
HE Zi, LIANG Shanquan, LIU Dan, JIANG Yawen, JIANG Zhengqiang, YANG Shaoqing
doaj   +1 more source

QTL study reveals candidate genes underlying host resistance in a Red Queen model system.

PLoS Genetics, 2023
Specific interactions of host and parasite genotypes can lead to balancing selection, maintaining genetic diversity within populations. In order to understand the drivers of such specific coevolution, it is necessary to identify the molecular ...
Maridel Fredericksen, Peter D Fields, Louis Du Pasquier, Virginie Ricci, Dieter Ebert   +4 more
doaj   +1 more source

The engagement of selectins and their ligands in colorectal cancer liver metastases [PDF]

, 2010
The colonization of the liver by colorectal cancer (CRC) cells is a complicated process which includes many stages, until macrometastases occur. The entrapment of malignant cells within the hepatic sinusoids and their interactions with resident non ...
Alves, Antoine, Aoki, Asai, Aychek, Ben-David, Bilzer, Bird, Blixt, Borsig, Borsig, Borsig, Braet, Bresalier, Brooks, Burdick, Burdick, Cho, Coppola, Dabrowska, Dernedde, Di Bella, Doebis, Dymicka-Piekarska, Fritzsche, Gangopadhyay, Garcia, Gout, Haier, Haier, Hakomori, Hanley, Hanley, Haraldsen, Hauser, He, Hu, Huang, Irimura, Ito, Jadhav, Klopocki, Kneuer, Knittel, Koike, Kudo, Kuhn, Laferriere, Laferriere, Lin, Liu, Malagolini, Man, Mannori, Matsumoto, Mayr, McCarty, McCarty, McLoughlin, McMillan, Mejias-Luque, Meyer, Minami, Mollicone, Muinelo-Romay, Nakamori, Nanashima, Napier, Ngan, Niers, Nihei, Opolski, Peeters, Peng, Petretti, Petzelbauer, Ragupathi, Romano, Rudmik, Sackstein, Sato, Sawada, Schluter, Sepp, Shirota, Sierko, Silverman, Sneath, Sousou, Sousou, Springer, Stevenson, Streit, Sturm, Subramaniam, Subramaniam, Subramaniam, Takada, Taura, Thomas, Thomas, Tremblay, Tremblay, Ugorski, Uner, Vekemans, Voura, Wagnerova, Wang, Wei, Wiese, Wilkins, Witz, Witz, Yamada, Yamaguchi, Yamane, Ye, Zarbock, Zhang, Zhang, Zipin   +121 more
core   +1 more source

Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma

EBioMedicine, 2020
Background: Aberrant fucosylation plays a critical role in lung cancer progression. Nevertheless, the key fucosyltransferase with prognostic significance in lung cancer patients, the enzyme's intracellular targets, and complex molecular mechanisms ...
Hsuan-Hsuan Lu, Shu-Yung Lin, Rueyhung Roc Weng, Yi-Hsiu Juan, Yen-Wei Chen, Hsin-Han Hou, Zheng-Ci Hung, Giovanni Audrey Oswita, Yi-Jhen Huang, Shih-Yun Guu, Kay-Hooi Khoo, Jin-Yuan Shih, Chong-Jen Yu, Hsing-Chen Tsai   +13 more
doaj   +1 more source

Profiling of aminoxyTMT-labeled bovine milk oligosaccharides reveals substantial variation in oligosaccharide abundance between dairy cattle breeds. [PDF]

, 2019
Free milk oligosaccharides are bioactive molecules that function as prebiotics and prevent infections that commonly afflict developing infants. To date, few publications have examined the factors affecting bovine milk oligosaccharide production among ...
Barile, Daniela, Colet, Emeline, Duchene, Chloe, Larsen, Lotte Bach, Poulsen, Nina A, Robinson, Randall C   +5 more
core   +2 more sources

Transforming growth factor β signaling upregulates the expression of human GDP-fucose transporter by activating transcription factor Sp1. [PDF]

PLoS ONE, 2013
GDP-fucose transporter plays a crucial role in fucosylation of glycoproteins by providing activated fucose donor, GDP-fucose, for fucosyltransferases in the lumen of the Golgi apparatus. Fucose-containing glycans are involved in many biological processes,
Yu-Xin Xu, Anna Ma, Li Liu
doaj   +1 more source

The Chemical Neurobiology of Carbohydrates [PDF]

, 2008
The cell surface displays a complex array of oligosaccharides, glycoproteins, and glycolipids. This diverse mixture of glycans contains a wealth of information, modulating a wide range of processes such as cell migration, proliferation, transcriptional ...
Hsieh-Wilson, Linda C., Murrey, Heather E.   +1 more
core   +1 more source

N-Glycomic and Transcriptomic Changes Associated with CDX1 mRNA Expression in Colorectal Cancer Cell Lines

Cells, 2019
The caudal-related homeobox protein 1 (CDX1) is a transcription factor, which is important in the development, differentiation, and homeostasis of the gut.
Stephanie Holst, Jennifer L. Wilding, Kamila Koprowska, Yoann Rombouts, Manfred Wuhrer   +4 more
doaj   +1 more source