Results 61 to 70 of about 5,422 (250)

Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells. [PDF]

, 2016
Alpha1,2-fucosyltransferases, FUT1 and FUT2, which transfer fucoses onto the terminal galactose of N-acetyl-lactosamine via α1,2-linkage have been shown to be highly expressed in various types of cancers.
Cho, Huan-Chieh, Ho, Ming-Yi, Hung, Jung-Tung, Tan, Keng-Poo, Yu, Alice Lin-Tsing, Yu, John   +5 more
core  

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Naïve T cells re-distribute to the lungs of selectin ligand deficient mice. [PDF]

PLoS ONE, 2010
Selectin mediated tethering represents one of the earliest steps in T cell extravasation into lymph nodes via high endothelial venules and is dependent on the biosynthesis of sialyl Lewis X (sLe(x)) ligands by several glycosyltransferases, including two ...
John R Harp, Thandi M Onami
doaj   +1 more source

Expression signatures of cisplatin- and trametinib-treated early-stage medaka melanomas [PDF]

, 2019
Small aquarium fish models provide useful systems not only for a better understanding of the molecular basis of many human diseases, but also for first-line screening to identify new drug candidates.
Boswell, William, Klotz, Barbara, Kneitz, Susanne, Lu, Yuan, Postlethwait, John, Shartl, Manfred, Walter, Ronald B, Warren, Wesley   +7 more
core   +2 more sources

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Cell adhesion mediated by a purified fucosyltransferase. [PDF]

Proceedings of the National Academy of Sciences, 1983
Human embryonic skin fibroblasts attach and spread on surfaces on which a fucosyltransferase purified from human milk has been immobilized. The adhesion-enhancing effect of the transferase involves specific interactions of the enzyme surface with the cell surface carbohydrate acceptors, as suggested by the following findings.
Heikki Rauvala, Jukka Finne, Jean-Paul Prieels   +2 more
openaire   +3 more sources

The Chemical Neurobiology of Carbohydrates [PDF]

, 2008
The cell surface displays a complex array of oligosaccharides, glycoproteins, and glycolipids. This diverse mixture of glycans contains a wealth of information, modulating a wide range of processes such as cell migration, proliferation, transcriptional ...
Hsieh-Wilson, Linda C., Murrey, Heather E.   +1 more
core   +1 more source

Maternal Dietary Fiber Intake During Lactation and Human Milk Oligosaccharide Fucosylation: a PRIMA Birth Cohort Study

Molecular Nutrition &Food Research, EarlyView.
Healthy breastfeeding women were recruited within the prospective birth cohort PRIMA. We collected a fresh human milk sample at 1 month postpartum to assess relative human milk oligosaccharide (HMO), HMO‐bound fucose levels, and secretor status. In univariate and multivariate linear regression analysis, we did not observe an association between ...
Anneke H. Hellinga, Samanta Cajic, Hanneke F. Linde, Arthur H. van Stigt, Jeanne H. M. de Vries, Elske M. Brouwer‐Brolsma, René Hennig, Erdmann Rapp, Marko Mank, Bernd Stahl, Aletta D. Kraneveld, Jeanette H. W. Leusen, Louis Bont, Belinda van't Land, the PRIMA group   +14 more
wiley   +1 more source

Metabolism-driven glycosylation represents therapeutic opportunities in interstitial lung diseases

Frontiers in Immunology
Metabolic changes are coupled with alteration in protein glycosylation. In this review, we will focus on macrophages that are pivotal in the pathogenesis of pulmonary fibrosis and sarcoidosis and thanks to their adaptable metabolism are an attractive ...
Katarzyna Drzewicka, Zbigniew Zasłona
doaj   +1 more source

Efficient Biosynthesis of 2’-Fucosyllactose Using Glycerol and Lactose in Engineered Escherichia coli [PDF]

Shipin Kexue
In this study, the de novo synthesis pathway of 2’-FL was established in Escherichia coli BL21star(DE3). The β-galactosidase gene (lacZ) and the UDP-glucose lipid carrier transferase gene (wcaJ) were knocked out by the CRISPR/Cas9 system.
HE Zi, LIANG Shanquan, LIU Dan, JIANG Yawen, JIANG Zhengqiang, YANG Shaoqing
doaj   +1 more source