Results 71 to 80 of about 2,493 (172)

Targeting Selectins and Their Ligands in Cancer

Frontiers in Oncology, 2016
Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids have been linked to increased immune cell evasion, drug evasion ...
Alessandro eNatoni, Matthew S Macauley, Michael eO'Dwyer, Michael eO'Dwyer   +3 more
doaj   +1 more source

Computational repurposing of FDA-approved drugs against glycosyltransferases driving cancer metastasis

In Silico Research in Biomedicine
Metastasis, the spread of cancer cells to distant sites, remains a critical challenge in cancer treatment. This process, primarily occurring via hematogenous and lymphatic pathways, significantly contributes to cancer mortality.
Prasanna H. Megalamani, Prashantha Karunakar, Shriraksha A, Maruti J. Gurav, Manasa J, Ashwini S. Sanji, Veeresh S, Vishwanath B. Chachadi   +7 more
doaj   +1 more source

Integrating transcriptomics, glycomics and glycoproteomics to characterize hepatitis B virus-associated hepatocellular carcinoma

Cell Communication and Signaling
Background Hepatocellular carcinoma (HCC) ranks as the third most common cause of cancer related death globally, representing a substantial challenge to global healthcare systems.
Zhuo Li, Na Zhang, Zewen Dong, Xin Wang, Jian Zhou, Juan Gao, Yunyun Yang, Jing Li, Feng Guan, Yue Zhou, Zengqi Tan   +10 more
doaj   +1 more source

Inhibition of fucosylation in human invasive ductal carcinoma reduces E‐selectin ligand expression, cell proliferation, and ERK1/2 and p38 MAPK activation

Molecular Oncology, 2018
Breast cancer tissue overexpresses fucosylated glycans, such as sialyl‐Lewis X/A (sLeX/A), and α‐1,3/4‐fucosyltransferases (FUTs) in relation to increased disease progression and metastasis.
Mylène A. Carrascal, Mariana Silva, José S. Ramalho, Cláudia Pen, Manuela Martins, Carlota Pascoal, Constança Amaral, Isabel Serrano, Maria José Oliveira, Robert Sackstein, Paula A. Videira   +10 more
doaj   +1 more source

Corrigendum: Fucosylated Antigens in Cancer: An Alliance Toward Tumor Progression, Metastasis, and Resistance to Chemotherapy

Frontiers in Oncology, 2018
Athanasios Blanas, Neha M. Sahasrabudhe, Ernesto Rodríguez, Yvette van Kooyk, Sandra J. van Vliet   +4 more
doaj   +1 more source

Creating a novel tobacco chassis with downregulated expression of α-1，3-fucosyltransferase 4

上海师范大学学报. 自然科学版
Tobacco (Nicotiana tabacum) is a widely used platform for producing recombinant proteins for clinical applications. However, achieving mammalian-like glycosylation modifications in plant-derived therapeutic proteins remains challenging, particularly in ...
SHAN Xuemeng, MUHAMMAD Naeem, WANG Yangzhong, HAN Rong, ZHOU Mengqian, ZHAO Weihua, ZHAO Lingxia   +6 more
doaj   +1 more source

Fucosyltransferase [PDF]

, 2020
openaire   +1 more source

C-6-Modified 2-F-Fucose Derivatives as Inhibitors of Fucosyltransferases. [PDF]

Chembiochem
Liu Y, Boons GJ.
europepmc   +1 more source

WrtF from <i>Rhizobium tropici</i> CIAT 899 is a GT-A fold fucosyltransferase that binds its donor nonproductively. [PDF]

Proc Natl Acad Sci U S A
Forrester TJB, Lin S, Lowary TL, Kimber MS.   +3 more
europepmc   +1 more source

Advances and challenges in plant N-glycoengineering: when fucosylation matters. [PDF]

Front Plant Sci
Gauba K, Kunnummel V, Castilho A.
europepmc   +1 more source