Results 61 to 70 of about 2,493 (172)

Post-Synthetic Defucosylation of AGP by Aspergillus nidulans α-1,2-Fucosidase Expressed in Arabidopsis Apoplast Induces Compensatory Upregulation of α-1,2-Fucosyltransferases.

PLoS ONE, 2016
Cell walls are essential components of plant cells which perform a variety of important functions for the different cell types, tissues and organs of a plant.
Gennady V Pogorelko, Nathan T Reem, Zachary T Young, Lauran Chambers, Olga A Zabotina   +4 more
doaj   +1 more source

N-Glycomic and Transcriptomic Changes Associated with CDX1 mRNA Expression in Colorectal Cancer Cell Lines

Cells, 2019
The caudal-related homeobox protein 1 (CDX1) is a transcription factor, which is important in the development, differentiation, and homeostasis of the gut.
Stephanie Holst, Jennifer L. Wilding, Kamila Koprowska, Yoann Rombouts, Manfred Wuhrer   +4 more
doaj   +1 more source

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, Volume 4, Issue 2, Page 91-107, June 2026.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source

Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies

MedComm, Volume 7, Issue 6, June 2026.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge, Liu Yu, Jiahe Lu, Aihetaimujiang Anwaier, Xiyue Xiao, Yonghao Chen, Dingwei Ye, Hailiang Zhang, Wenhao Xu, Wenbin Dai   +9 more
wiley   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, Volume 13, Issue 30, 28 May 2026.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, Volume 45, Issue 3, Page 455-475, May/June 2026.
ABSTRACT Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Novel function of pregnancy-associated plasma protein A: promotes endometrium receptivity by up-regulating N-fucosylation

Scientific Reports, 2017
Glycosylation of uterine endometrial cells plays important roles to determine their receptive function to blastocysts. Trophoblast-derived pregnancy-associated plasma protein A (PAPPA) is specifically elevated in pregnant women serum, and is known to ...
Ming Yu, Jiao Wang, Shuai Liu, Xiaoqi Wang, Qiu Yan   +4 more
doaj   +1 more source

Defective O-fucosylation of EDIL3 attenuates invasion and vascular remodeling of trophoblasts via LIFR signaling pathway in preeclampsia

Nature Communications
Preeclampsia (PE) is a severe pregnancy disorder caused by placental dysfunction. Protein O-fucosylation is a type of protein post translational modification that is catalyzed by protein O-fucosyltransferases (poFUTs).
Yaqi Li, Hongpan Wu, Yuyu Lei, Shuyu Bai, Jiao Wang, Bin Yan, Yubo Liu, Shuai Liu   +7 more
doaj   +1 more source

The fucose salvage pathway inhibits invadopodia formation and extracellular matrix degradation in melanoma cells.

PLoS ONE, 2018
The fucose salvage pathway is a two-step process in which mammalian cells transform L-fucose into GDP-L-fucose, a universal fucose donor used by fucosyltransferases to modify glycans.
Tyler Keeley, Shengchen Lin, Daniel K Lester, Eric K Lau, Shengyu Yang   +4 more
doaj   +1 more source

Infection with the gastrointestinal nematode Ostertagia ostertagi in cattle affects mucus biosynthesis in the abomasum

Veterinary Research, 2011
The mucus layer in the gastrointestinal (GI) tract is considered to be the first line of defense to the external environment. Alteration in mucus components has been reported to occur during intestinal nematode infection in ruminants, but the role of ...
Rinaldi Manuela, Dreesen Leentje, Hoorens Prisca R, Li Robert W, Claerebout Edwin, Goddeeris Bruno, Vercruysse Jozef, Van Den Broek Wim, Geldhof Peter   +8 more
doaj   +1 more source