Results 91 to 100 of about 3,115 (208)

In This Issue

, 2018
An Inhibitory Molecule Keeps Multiple Myeloma in Check See article p. 2581 The Evolution of KIR and HLA Diversity See article p. 2640 Role of Fucosyltransferases in Memory CD4+ T Cells See article p.

core   +1 more source

Differential Labeling of Glycoproteins with Alkynyl Fucose Analogs

, 2020
Fucosylated glycans critically regulate the physiological functions of proteins and cells. Alterations in levels of fucosylated glycans are associated with various diseases. For detection and functional modulation of fucosylated glycans, chemical biology
Chizuko Yonekawa, Kazuki Nakajima, Tetsuya Okajima, Hideyuki Takeuchi, Chenyu Ma, Yasuhiko Kizuka, Masamichi Nagae, Robert S. Haltiwanger, Huilin Hao   +8 more
core   +1 more source

Human fucosyltransferase 6 enables prostate cancer metastasis to bone [PDF]

, 2014
Background: The interaction between human prostate cancer (PCa) cells and bone marrow (BM) endothelium follows a rolling-and-adhesion cascade mediated by E-selectin ligand (ESL): E-selectin.
King, M R, Barthel, S R, Hsu, J-w, Li, J, Lee, Y-F, Dimitroff, C J, Guillebon, A D   +6 more
core   +1 more source

The fucose salvage pathway inhibits invadopodia formation and extracellular matrix degradation in melanoma cells.

PLoS ONE, 2018
The fucose salvage pathway is a two-step process in which mammalian cells transform L-fucose into GDP-L-fucose, a universal fucose donor used by fucosyltransferases to modify glycans.
Tyler Keeley, Shengchen Lin, Daniel K Lester, Eric K Lau, Shengyu Yang   +4 more
doaj   +1 more source

Infection with the gastrointestinal nematode Ostertagia ostertagi in cattle affects mucus biosynthesis in the abomasum

Veterinary Research, 2011
The mucus layer in the gastrointestinal (GI) tract is considered to be the first line of defense to the external environment. Alteration in mucus components has been reported to occur during intestinal nematode infection in ruminants, but the role of ...
Rinaldi Manuela, Dreesen Leentje, Hoorens Prisca R, Li Robert W, Claerebout Edwin, Goddeeris Bruno, Vercruysse Jozef, Van Den Broek Wim, Geldhof Peter   +8 more
doaj   +1 more source

Targeting Selectins and Their Ligands in Cancer

Frontiers in Oncology, 2016
Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids have been linked to increased immune cell evasion, drug evasion ...
Alessandro eNatoni, Matthew S Macauley, Michael eO'Dwyer, Michael eO'Dwyer   +3 more
doaj   +1 more source

Computational repurposing of FDA-approved drugs against glycosyltransferases driving cancer metastasis

In Silico Research in Biomedicine
Metastasis, the spread of cancer cells to distant sites, remains a critical challenge in cancer treatment. This process, primarily occurring via hematogenous and lymphatic pathways, significantly contributes to cancer mortality.
Prasanna H. Megalamani, Prashantha Karunakar, Shriraksha A, Maruti J. Gurav, Manasa J, Ashwini S. Sanji, Veeresh S, Vishwanath B. Chachadi   +7 more
doaj   +1 more source

Plant fucosyltransferase FUT11 distorts the sugar acceptor to catalyze via a transient oxocarbenium intermediate mechanism

Nature Communications
Glycosyltransferases catalyze glycosidic bond formation by activating the donor sugar, while the sugar acceptor substrate is considered passive, maintaining a chair conformation during catalysis.
Víctor Taleb, Ignacio Sanz-Martínez, Sonia Serna, María Bort-Griñó, Yoshiki Narimatsu, Sanae Furukawa, Niels C. Reichardt, Henrik Clausen, Pedro Merino, Ramon Hurtado-Guerrero   +9 more
doaj   +1 more source

Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking

, 2019
How cancer cells bind to vascular surfaces and extravasate into target organs is an underappreciated, yet essential step in metastasis. We postulate that the metastatic process involves discrete adhesive interactions between circulating cancer cells and ...
Barthel, Steven R., Hays, Danielle L., Pienta, Kenneth J., Cho, Jaehyung, Opperman, Matthew J., Dimitroff, Charles J., Wiese, Georg K., Siddiqui, Javed, Furie, Bruce   +8 more
core   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source