Bis(oxotremorine) fumarate bis(fumaric acid)
IUCrData, 2022 The title compound, bis(oxotremorine) fumarate bis(fumaric acid) {systematic name: 1-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]pyrrolidinium (2E)-but-2-enedioate bis[(2E)-but-2-enedioic acid]}, 2C12H19N2O+·C4H2O42−·2C4H4O4, has a single oxotremorine monocation
Marilyn Naeem +3 more
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Comparative Effectiveness of Fumarates Versus Sphingosine-1-Phosphate Receptor Modulators in Black Patients with Multiple Sclerosis [PDF]
Neurology and TherapyIntroduction Multiple sclerosis (MS) is a heterogeneous disease that disproportionately impacts Black people with MS (PwMS), who experience more severe disease and higher relapse rates compared with non-Black populations.
Sophia Woodson +12 more
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Fumarate-based drugs protect against neuroinflammation via upregulation of anti-ferroptotic pathways [PDF]
Journal of NeuroinflammationFerroptosis is defined as iron dependent non-apoptotic cell death. It is based on peroxidation of polyunsaturated phospholipids and subsequent membrane rupture.
Katinka Fischer +10 more
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Real-World Treatment Outcomes in Black, Hispanic, Asian, and White People with Multiple Sclerosis Treated with Fumarates in the USA [PDF]
Neurology and TherapyIntroduction Multiple sclerosis (MS) is a heterogeneous disease affecting a diverse population. Compared with white people with MS (PwMS), Black PwMS have more severe disease and higher incidence of MS, whereas Hispanic PwMS experience earlier onset ...
Sophia Woodson +12 more
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Clinical characteristics and treatment outcomes in multiple sclerosis patients treated with anti-CD20s who switched to fumarates: a retrospective analysis of a US healthcare claims database [PDF]
Journal of Comparative Effectiveness ResearchAim: Anti-CD20 monoclonal antibodies and fumarates are common multiple sclerosis (MS) diseasemodifying therapies (DMTs). Data on switching from anti-CD20s to other DMTs are limited.
Aliza B Ben-Zacharia +8 more
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Natalizumab and fumarate treatment differentially modulate CD4+ T cell and B cell subtypes in multiple sclerosis patients without impacting durable COVID-19 vaccine responses [PDF]
Frontiers in ImmunologyBackgroundThere is a greater risk of complications from severe COVID-19 in immunocompromised patients with multiple sclerosis (pwMS) treated with certain disease-modifying therapies (DMTs), as well as a diminished vaccine response.MethodsIn this ...
Ryan Curtin +33 more
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Sleep-related breathing disorder (central sleep apnoea) improved coincidentally by medical therapy with fumarates (dimethyl fumarate) [PDF]
Drugs in Context, 2023 Central sleep apnoea (CSA) is a sleep disorder characterized by the repeated cessation or reduction of both airflow and ventilatory effort when sleeping.
Abdulmajeed M Albadi +2 more
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Polymorphism and Multi-Component Crystal Formation of GABA and Gabapentin [PDF]
Pharmaceutics, 2023 This study exploits the polymorphism and multi-component crystal formation of γ-amino butanoic acid (GABA) and its pharmaceutically active derivative, gabapentin.
Daniel Komisarek +5 more
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How should we do in the selection and follow-up of systemic conventional treatments in psoriasis? [PDF]
Exploration of Musculoskeletal Diseases, 2023 There is an increasing need for appropriate effective treatment and long-term disease control in patients with psoriasis because of the decreased quality of life, increased physicosocial deficits and associated co-morbidities.
Sevgi Akarsu
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Acta Crystallographica Section E: Crystallographic Communications, 2021 The solid-state structures of the salts of three psilacetin derivatives, namely, 4-acetoxy-N-ethyl-N-methyltryptammonium (4-AcO-MET) hydrofumarate {systematic name: [2-(4-acetyloxy-1H-indol-3-yl)ethyl](methyl)ethylazanium 3-carboxyprop-2-enoate ...
Duyen N. K. Pham +3 more
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