Results 171 to 180 of about 2,909 (219)

Teriflunomide and monomethylfumarate target HIV-induced neuroinflammation and neurotoxicity [PDF]

, 2017

core   +1 more source

Progress towards the elimination of vertical transmission of HIV, syphilis and hepatitis B in 21 high‐burden countries

Journal of the International AIDS Society, Volume 29, Issue 4, April 2026.
Abstract Introduction Elimination of mother‐to‐child transmission (EMTCT) of HIV, syphilis and hepatitis B by 2030 is a global goal endorsed by countries. To achieve EMTCT, countries need to meet targets for programme and impact indicators. Methods We examined progress and gaps in service delivery across the three infections among 21 countries with a ...
Melanie M. Taylor, Rania A. Tohme, Robert McDonald, Michele Montandon   +3 more
wiley   +1 more source

Impact of Age on Switching or Stopping Disease Modifying Therapies in Multiple Sclerosis. [PDF]

Neurotherapeutics
Siddiqui A, Hua LH.
europepmc   +1 more source

Fibrinogen‐Like Protein 2 Modulates B Cell Mucosal Immunity by Suppressing Receptor for Activated C‐Kinase 1‐Mediated AKT Phosphorylation

MedComm, Volume 7, Issue 4, April 2026.
In our study, B cells are activated with the assistance of Breg and Tfh cells, subsequently differentiating into IgA+ plasma cells. These plasma cells produce secretory IgA (sIgA) at mucosal surfaces to combat viral and parasitic infections. Mechanistically, Fgl2 directly binds to Rack1.
Jiang Chang, Da Huang, Wei Yuan, Jianing Tang, Jingzhi Yang, Yuying Chen, Zhize Yuan, Yizhi Wu, Di Wu, Weiming Yan, Qin Ning   +10 more
wiley   +1 more source

Modulation of Pulmonary Inflammation and the Redox Pathway In Vitro and In Vivo by Fumaric Ester. [PDF]

Antioxidants (Basel)
Oliveira AP, Figueiredo-Junior AT, Mineiro PCO, Mota EC, Amorim CS, Valenca HDM, Gomes ACCA, Serra SSS, Silva PL, Takiya CM, Moraes JA, Valenca SS, Lanzetti M.   +12 more
europepmc   +1 more source

Multi‐Omics Analysis in Autoimmunity: Identification of MicroRNA Regulatory Networks and Cell‐Type‐Specific Dysregulations in Multiple Sclerosis and Type 1 Diabetes

MedComm, Volume 7, Issue 4, April 2026.
This study evaluates the expression of microRNAs (miRNAs) in three distinct immune subsets (CD14+ monocytes, neutrophils, and CD8+ T cells) in multiple sclerosis and type 1 diabetes, reporting the presence of unique alteration patterns. Our integrative multi‐omics analysis suggests that miRNAs play a pivotal role in the differentiation and migration of
Jacopo Ronchi, Roberta Rigolio, Davide Maria Trevisan, Angela Papagna, Angela Stabilini, Martina Gallinaro, Maria Letizia Fusco, Martina Gaia Cogo, Guido Cavaletti, Giovanni Malerba, Manuela Battaglia, Maria Foti   +11 more
wiley   +1 more source

New onset lymphopenia in patients with relapsing multiple sclerosis switching from long-standing dimethyl fumarate treatment to diroximel fumarate: A case series. [PDF]

Mult Scler
Schneider M, Kramer J, Banks A, Moses H.
europepmc   +1 more source

Immunocompromised Status Definition in Observational Studies Using Electronic Health Records: A Scoping Review and a Proposal for a Phenotype Identification Algorithm

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.
ABSTRACT Immunocompromised individuals experience an impaired immune function due to conditions that might be either congenital or acquired over the course of their lives. Epidemiological studies often rely on clinical definitions which, in some cases, benefit from being translated into machine‐readable algorithms for application to electronic health ...
Judit Riera‐Arnau, Nicoletta Luxi, Fabio Riefolo, Martín Solorzano, Irene Pazos, Elena Ballarín, Lise Skovgaard Svingel, Lorenzo Chiusaroli, Elisa Martín‐Merino, Elisa Barbieri, María Lopez‐Lasanta, Sima Mohammadi, Denis Rotta, Alexandra Pacurariu, Catherine Cohet, Miriam Sturkenboom, Carlos E. Durán, on behalf of the SAFETY‐VAC study consortium, Carlos E. Durán, Miriam Sturkenboom, Judit Riera‐Arnau, Nicoletta Luxi, Olaf Klungel, Patrick Souverein, Sima Mohammadi, Fabio Riefolo, Irene Pazos, Rosa Gini, Davide Messina, Giuseppe Roberto, Carlo Giaquinto, Elisa Barbieri, Luca Stona, Felipe Villalobos, Martín Solorzano, Carlo Alberto Bissacco, Antonio Gimeno, Beatriz Poblador, Mercedes Aza, Aida Moreno, Alejandro Santos, Vera Ehrenstein, Lise Skovgaard Svingel, Benjamin Randeris Johannesen, Cécile Droz‐Perroteau, Laure Carcaillon‐Bentata, Anna‐Mija Tolppanen, Sirpa Hartikainen, Thuan Vo, Anne Paakinaho, Blair Rajamaki, Hedvig Nordeng, Saeed Hayati, Mahmoud Zidan, Juan José Carreras Martínez, Arantxa Urchueguía Fornes, Elisa Correcher Martínez, Javier Díez‐Domingo, Mar Martin, Patricia Garcia‐Poza, Airam de Burgos, Belén Castillo‐Cano, Elisa Martín‐Merino   +62 more
wiley   +1 more source

ADSL-produced fumarate increases BECN1 dimethylation to promote autophagy and liver tumor growth. [PDF]

Autophagy
Wang L, Ji G, Duan Y, Zheng P, Hu Z, Wang Z, Xu D.   +6 more
europepmc   +1 more source

Dynamic Lysine Acetylation Disrupts Isocitrate Lyase Function and Enables Metabolic Optimisation

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Acetyl‐phosphate–dependent acetylation of E. coli isocitrate lyase (ICL) at K13 and K308 inhibits its activity, while CobB‐mediated deacetylation restores function. Introducing K13R/K308R mutations enhances metabolic balance and increases lycopene yield by 61%, providing a promising approach to optimise microbial cell factories through natural ...
Adrián Martínez‐Vivancos, Beatriz Gomariz‐Turpin, Gema Lozano‐Terol, Rosa Alba Sola‐Martínez, Álvaro Ortega, Julia Gallego‐Jara, Teresa de Diego Puente   +6 more
wiley   +1 more source