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Early toxic effects of fumonisin B1 in rat liver
Human & Experimental Toxicology, 2008Mycotoxin fumonisin B1 (FB1) is hepatotoxic and carcinogenic in experimental animals. It is known that long-term exposure of experimental animals to FB1 causes apoptosis and lipid peroxidation. In this study, male adult Wistar rats were treated with single FB1 doses (5, 50, and 500 μg/kg b.w.) and sacrificed 4, 24, and 48 hours after treatment ...
Domijan, Ana-Marija +7 more
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In Vitro Metabolism of Fumonisin B1 by Ruminal Microflora
Veterinary Research Communications, 2000Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium moniliforme and F. proliferatum. Little is known of its metabolic fate after oral ingestion in ruminants, but these animals are reported to be tolerant towards FB1. The metabolism of this mycotoxin was evaluated following incubation (1 microg/ml) in ruminal fluid for up to 72 h, in the presence or ...
Caloni, F. +5 more
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Toxicological effects of fumonisin B1 in combination with other Fusarium toxins.
Food and Chemical Toxicology, 2018Fusarium is a fungal genus spread worldwide commonly associated to the production of several mycotoxins, where fumonisins (FBs) are of major importance due to its prevalence. Since mycotoxins have been reported to cause deleterious effects on mammalians,
Jessica Audrey Feijó Corrêa +4 more
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Fumonisin B1 toxicity examinations
2000Fumonizini su skupina ne tako davno karakteriziranih mikotoksina stvorenih od pojednih plijesni Fusarium vrsta, od kojih su najvažnije F. moniliforme i F. proliferatum, zbog toga što često inficiraju kulture žitarica diljem svijeta. Među fumonizinima je fumonizin B1 (FB1) nejčešće zastupljen u prirodno kontaminiranoj hrani i krmivima.
openaire
Fumonisin B1 is fetotoxic in rats.
Veterinary and human toxicology, 1995Groups of 5-6 pregnant F344/N rats were dosed (po) from d 8 to 12 of gestation with 30 or 60 mg purified fumonisin B1 (FB1)/kg body weight, or with a fat-soluble extract of Fusarium proliferatum/corn culture derived from an amount of corn culture that would provide approximately 60 mg FB1/kg. Control rats were dosed with water or corn oil.
S, Lebepe-Mazur +4 more
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Mechanism of ceramide synthase inhibition by fumonisin B1
StructureCeramide synthases (CerSs) play crucial roles in sphingolipid metabolism and have emerged as promising drug targets for metabolic diseases, cancers, and antifungal therapy. However, the therapeutic targeting of CerSs has been hindered by a limited understanding of their inhibition mechanisms by small molecules.
Zike Zhang, Qi Fang, Tian Xie, Xin Gong
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Occurrence of Fumonisin B1 and Hydrolyzed Fumonisin B1 in Mexican Nixtamalized Cornmeal
Bulletin of Environmental Contamination and Toxicology, 2005M O, Cortez-Rocha +7 more
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