Results 71 to 80 of about 14,894,566 (393)
Functional Implications of DNA Methylation in Adipose Biology. [PDF]
, 2019 The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic issue. The dysregulation of adipose tissue biology is central to the development of these two metabolic disorders, as adipose tissue plays a pivotal role ...
Kang, Sona, Ma, Xiang
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez +13 more
wiley +1 more source
Understanding Genomic Evolution of Olfactory Receptors through Fractal and Mathematical Morphology [PDF]
, 2011 Fractals and Mathematical Morphology are immensely used to study many problems in different branches of science and technology including the domain of Biology. There are many more unrevealed facts and figures of genes and genome in Computational Biology.
Arunava Goswami +5 more
core +1 more source
Engineering orthogonal dual transcription factors for multi-input synthetic promoters [PDF]
, 2016 Synthetic biology has seen an explosive growth in the capability of engineering artificial gene circuits from transcription factors (TFs), particularly in bacteria. However, most artificial networks still employ the same core set of TFs (for example LacI,
Broedel, AK, Isalan, M, Jaramillo, A
core +2 more sources
Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma
Pediatric Blood &Cancer, EarlyView.ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack +12 more
wiley +1 more source
Nature CommunicationsDespite the importance of keratinocytes in epidermal structure and function, the molecular mechanisms regulating the division of these cells remain poorly understood. Herein, we demonstrate an essential role for cilia and flagella associated protein 100 (
Shuang Sun +9 more
doaj +1 more source
IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis
Scientific Reports, 2017 Myeloid cells, key players in atherosclerosis, take up and present antigens, leading to systemic and local T cell activation. The recruitment and activation of immune cells to the aorta in atherosclerosis is regulated by adhesion molecules, chemokines ...
Iuliia O. Peshkova +4 more
doaj +1 more source
Primate Craniofacial Function and Biology [PDF]
, 2010 Book review: Primate Craniofacial Function and ...
Constantino, Paul J
core +1 more source
An evolutionary approach to Function [PDF]
, 2009 The distinction between function and role is a vexed and difficult one. While the distinction appears to be useful, in practice it is hard to apply; this can be even worse when applying this distinction to biology.
Phillip Lord
core +4 more sources
YAP/TAZ as master regulators in cancer – modulation, function and therapeutic approaches
Nature Cancer, 2022 Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ) in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ biology, their regulation by Hippo signaling and mechanotransduction and ...
S. Piccolo +3 more
semanticscholar +1 more source