Results 91 to 100 of about 304,354 (194)

Focal Spot, Spring 2009 [PDF]

, 2009
https://digitalcommons.wustl.edu/focal_spot_archives/1111/thumbnail ...

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Amyloid and tau accumulate across distinct spatial networks and are differentially associated with brain connectivity

eLife, 2019
The abnormal accumulation of amyloid-β and tau targets specific spatial networks in Alzheimer’s disease. However, the relationship between these networks across different disease stages and their association with brain connectivity has not been explored.
Joana B Pereira, Rik Ossenkoppele, Sebastian Palmqvist, Tor Olof Strandberg, Ruben Smith, Eric Westman, Oskar Hansson   +6 more
doaj   +1 more source

Introduction to Protein Structure Prediction [PDF]

, 2017
This chapter gives a graceful introduction to problem of protein three- dimensional structure prediction, and focuses on how to make structural sense out of a single input sequence with unknown structure, the 'query' or 'target' sequence.
Abeln, Sanne, Feenstra, K. Anton, Heringa, Jaap   +2 more
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The house that Kocuria built: A potential role for functional amyloid in the unique cube-based structure of K. varians biofilms

The Microbe
Biofilm is the dominant growth mode of microorganisms, providing protection, surface adhesion and synergy between co-habiting organisms. Many aspects of biofilm formation and architecture remain unknown and vary greatly among different species.
Daniel E. Otzen, Gabriel Antonio S. Minero, Henriette L. Røder, Anders M. Torp, Jakob Herschend, Lotte G. Nielsen, Olena Moshynets, Janni Nielsen, Rikke L. Meyer, Morten K.D. Dueholm, Mette Burmølle   +10 more
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The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults

Alzheimer’s Research & Therapy, 2020
Background Pathological processes contributing to Alzheimer’s disease begin decades prior to the onset of clinical symptoms. There is significant variation in cognitive changes in the presence of pathology, functional connectivity may be a marker of ...
Chemin Lin, Maria Ly, Helmet T. Karim, Wenjing Wei, Beth E. Snitz, William E. Klunk, Howard J. Aizenstein   +6 more
doaj   +1 more source

The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid

Advanced Science
Amyloids, once viewed solely as pathological hallmarks, are now recognized as widespread and versatile functional protein assemblies. Bacterial functional amyloids (FuBAs), particularly curli (CsgA) from Escherichia coli and FapC from Pseudomonas, have ...
Samuel Peña‐Díaz, Yanting Jiang, Zhefei Zhang, Anders Daugberg, Pedro Ferreira, Marcos López Hernández, Chandrika Mittal, Maria Joao Ramos, Jan Skov Pedersen, Morten Kam Dahl Dueholm, Cao Qin, Huabing Wang, Daniel E. Otzen   +12 more
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Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2019
Background A decline in instrumental activities of daily living (IADL) correlates with the progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD) dementia and has been associated with frontal and parietal hypometabolism, lower ...
Omar A. Halawa, Jennifer R. Gatchel, Rebecca E. Amariglio, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Gad A. Marshall, Alzheimer’s Disease Neuroimaging Initiative   +7 more
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Multivariate MR Biomarkers Better Predict Cognitive Dysfunction in Mouse Models of Alzheimers Disease

, 2018
To understand multifactorial conditions such as Alzheimers disease (AD) we need brain signatures that predict the impact of multiple pathologies and their interactions.
Anderson, RJ, Avants, Brian B, Badea, Alexandra, Colton, Carol, Delpratt, Natalie A, Dibb, Russell, Liu, Chunlei, Qi, Yi, Wei, Hongjiang, Wetsel, William C   +9 more
core  

Effect of Non-Coding RNA on Post-Transcriptional Gene Silencing of Alzheimer Disease [PDF]

, 2010
A large amount of hidden biological information is contained in the human genome, which is not expressed or revealed in the form of proteins; the usual end product form of gene expression.
Arun Mohan, Deepa Gopakumar, Krishnan Namboori, Premkumar P, Radhagayathri K.U., Ramachandran K.I., Varun Gopal, Vasavi C.S.   +7 more
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Differential Effects of Lipid Bilayers on αPSM Peptide Functional Amyloid Formation. [PDF]

Int J Mol Sci, 2023
Kristoffersen K, Hansen KH, Andreasen M.
europepmc   +1 more source