Results 61 to 70 of about 11,568 (285)

Multiphoton absorption in amyloid protein fibres [PDF]

, 2013
Fibrillization of peptides leads to the formation of amyloid fibres, which, when in large aggregates, are responsible for diseases such as Alzheimer's and Parkinson's.
AM McDonagh, Bengt Norden, D Rativa, DJ Selkoe, E Collini, EP Lundberg, ES Voropai, F Chiti, JC Rochet, JF Smith, JH Viles, JL Jimenez, M Drobizhev, M Fändrich, M Reches, M Samoc, M Samoc, M Samoc, M Sheikh-Bahae, Marek Samoc, P Hanczyc, Piotr Hanczyc, PP Markowicz, R Friedman, RL Roberts, RM Murphy, RM Williams, SB Prusiner, SJ Chung, T Schwich, WD McCubbin, X Wang, Y Meshalkin   +32 more
core   +1 more source

Traumatic Microhemorrhages Are Not Synonymous With Axonal Injury

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diffuse axonal injury (DAI) is caused by acceleration‐deceleration forces during trauma that shear white matter tracts. Susceptibility‐weighted MRI (SWI) identifies microbleeds that are considered the radiologic hallmark of DAI and are used in clinical prognostication.
Karinn Sytsma, Rhonda Mittenzwei, Heather Maioli, Amanda Kirkland, C. Dirk Keene, Ramon Diaz‐Arrastia, Christine Mac Donald, Chiara Maffei, Brian L. Edlow, Amber L. Nolan   +9 more
wiley   +1 more source

Disease Transmission by Misfolded Prion-Protein Isoforms, Prion-Like Amyloids, Functional Amyloids and the Central Dogma

Biology, 2016
In 1982, the term “prions” (proteinaceous infectious particles) was coined to specify a new principle of infection. A misfolded isoform of a cellular protein has been described as the causative agent of a fatal neurodegenerative disease. At the beginning
Martin L. Daus
doaj   +1 more source

Mapping the Beta-Sheet Structure of the Yeast Prion Sup35 through Creation of Targeted Mutant Forms [PDF]

, 2013
Proteins with an aggregated form rich in beta-sheet structure are known as amyloids, of which a subset are infectious. These infectious proteins are known as prions and cause diseases including bovine spongiform encephalopathy (“Mad Cow” disease ...
Davis, Emily K., Knox, James D., Palacios, Daniel   +2 more
core   +1 more source

Alzheimer's Amyloid-β is an Antimicrobial Peptide: A Review of the Evidence [PDF]

, 2018
The final publication is available at IOS Press through http://dx.doi.org/10.3233/JAD-171133.The amyloid-β (Aβ) peptide has long been considered to be the driving force behind Alzheimer’s disease (AD).
Brothers, Holly, Gosztyla, Maya, Robinson, Stephen   +2 more
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Structural insights into Escherichia coli CsgA amyloid fibril assembly revisited

mBio
Curli are a widespread component of proteobacterial biofilms. They are functional amyloid fibers that aid in structuring the extracellular matrix that surrounds these multicellular communities. As a functional amyloid, they are the product of a dedicated
Mike Sleutel, Han Remaut
doaj   +1 more source

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

eLife, 2020
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. While genetic and environmental factors can influence amyloid formation,
Timothy R Sampson, Collin Challis, Neha Jain, Anastasiya Moiseyenko, Mark S Ladinsky, Gauri G Shastri, Taren Thron, Brittany D Needham, Istvan Horvath, Justine W Debelius, Stefan Janssen, Rob Knight, Pernilla Wittung-Stafshede, Viviana Gradinaru, Matthew Chapman, Sarkis K Mazmanian   +15 more
doaj   +1 more source

Functional amyloid formation by Streptococcus mutans [PDF]

Microbiology, 2012
Dental caries is a common infectious disease associated with acidogenic and aciduric bacteria, including Streptococcus mutans. Organisms that cause cavities form recalcitrant biofilms, generate acids from dietary sugars and tolerate acid end products. It has recently been recognized that micro-organisms can produce functional amyloids that are integral
M W, Oli, H N, Otoo, P J, Crowley, K P, Heim, M M, Nascimento, C B, Ramsook, P N, Lipke, L J, Brady   +7 more
openaire   +2 more sources