Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation.
PLoS Biology, 2016 Amyloids are ordered protein aggregates that are typically associated with neurodegenerative diseases and cognitive impairment. By contrast, the amyloid-like state of the neuronal RNA binding protein Orb2 in Drosophila was recently implicated in memory ...
Rubén Hervás +15 more
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Pharmaceutics, 2022 The coordination between histidine-rich peptides and divalent cations supports the formation of nano- and micro-scale protein biomaterials, including toxic and non-toxic functional amyloids, which can be adapted as drug delivery systems.
Julieta María Sánchez +10 more
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STITCHER: Dynamic assembly of likely amyloid and prion β-structures from secondary structure predictions [PDF]
, 2011 The supersecondary structure of amyloids and prions, proteins of intense clinical and biological interest, are difficult to determine by standard experimental or computational means.
Berger, Bonnie +5 more
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Meta-structure correlation in protein space unveils different selection rules for folded and intrinsically disordered proteins [PDF]
, 2012 The number of existing protein sequences spans a very small fraction of sequence space. Natural proteins have overcome a strong negative selective pressure to avoid the formation of insoluble aggregates.
Campen +25 more
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Pathogens, 2022 Candida-macrophage interactions are important immune defense responses associated with disseminated and deep-seated candidiasis in humans. Cells of Candida spp.
Stephen A. Klotz +2 more
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Molecular Dynamics Studies on 3D Structures of the Hydrophobic Region PrP(109-136) [PDF]
, 2013 Prion diseases caused by the conversion from a soluble normal cellular prion protein into insoluble abnormally folded infectious prions, are invariably fatal and highly infectious degenerative diseases that affect a wide variety of mammalian species. The
Zhang, Jiapu, Zhang, Yuanli
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Structure-function analysis of the curli accessory protein CsgE defines surfaces essential for coordinating amyloid fiber formation [PDF]
, 2018 Curli amyloid fibers are produced as part of the extracellular biofilm matrix and are composed primarily of the major structural subunit CsgA. The CsgE chaperone facilitates the secretion of CsgA through CsgG by forming a cap at the base of the nonameric
Amarasinghe, Gaya K +13 more
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The propensity of the bacterial rodlin protein RdlB to form amyloid fibrils determines its function in Streptomyces coelicolor. [PDF]
, 2017 Streptomyces bacteria form reproductive aerial hyphae that are covered with a pattern of pairwise aligned fibrils called rodlets. The presence of the rodlet layer requires two homologous rodlin proteins, RdlA and RdlB, and the functional amyloid chaplin ...
Claessen, Dennis +8 more
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Scientific Reports, 2018 Here, we report that minimal functional gelsolin i.e. fragment 28–161 can display F-actin depolymerizing property even after heating the protein to 80 °C. Small angle X-ray scattering (SAXS) data analysis confirmed that under Ca2+-free conditions, 28–161
Maulik D. Badmalia +6 more
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Profiling the serum protein corona of fibrillar human islet amyloid polypeptide [PDF]
, 2018 Amyloids may be regarded as native nanomaterials that form in the presence of complex protein mixtures. By drawing an analogy with the physicochemical properties of nanoparticles in biological fluids, we hypothesized that amyloids should form a protein ...
Davis, Thomas P. +10 more
core +2 more sources