Results 61 to 70 of about 3,255,404 (222)

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

, 2009
Amyloids are highly organized cross-beta-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimers disease and type II diabetes.
Nilsson, Peter,, Vale, Wylie,, Vale, Wylie, Riek, Roland, Rivier, Jean,, Simon, Rozalyn, Rivier, Jean, Nilsson, K. Peter R., Singru, Praful S., Singru, Praful S,, Simon, Rozalyn,, Sawchenko, Paul,, Sawchenko, Paul, Eisenberg, David,, Rissman, Robert A,, Jessberger, Sebastian,, Jessberger, Sebastian, Rissman, Robert A., Riek, Roland,, Schubert, David,, Schubert, David, Perrin, Marilyn H,, Perrin, Marilyn H., Sawaya, Michael R., Sawaya, Michael R,, Eisenberg, David, Vadodaria, Krishna,, Maji, Samir K., Vadodaria, Krishna, Maji, Samir K,   +29 more
core   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Searching for novel functional amyloids in biofilms [PDF]

, 2018
The identification of novel amyloids is key to understand the many roles of amyloids in biofilm structure and function. Unfortunately, isolation of amyloids is a challenging and not always successful process.
Hove Hansen, Susan, Danielsen, Heidi Nolsøe, Herbst, Florian-Alexander, Dueholm, Morten Simonsen; id_orcid, Nielsen, Per Halkjær   +4 more
core   +2 more sources

Nonpathological extracellular amyloid is present during normal epididymal sperm maturation. [PDF]

PLoS ONE, 2012
Amyloids are aggregated proteins characterized by a specific cross-β-sheet structure and are typically associated with neurodegenerative diseases including Alzheimer's disease.
Sandra Whelly, Seethal Johnson, Jonathan Powell, Clinton Borchardt, Mary Catherine Hastert, Gail A Cornwall   +5 more
doaj   +1 more source

Bacterial inclusion bodies are industrially exploitable amyloids. [PDF]

, 2018
Understanding the structure, functionalities and biology of functional amyloids is an issue of emerging interest. Inclusion bodies, namely protein clusters formed in recombinant bacteria during protein production processes, have emerged as unanticipated,
Garcia-Fruitos, Elena, Valdez-Cruz, Norma A, Villaverde, Antonio, de Marco, Ario, Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia, Trujillo-Roldán, Mauricio A., Vazquez, Esther, Trujillo-Roldan, Mauricio, Valdez-Cruz, Norma, Mitraki, Anna, Valdez-Cruz, Norma A., Ferrer-Miralles, Neus, Rinas, Ursula, Peternel, Spela, Trujillo-Roldán, Mauricio A   +14 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Biofilm-associated proteins: from the gut biofilms to neurodegeneration

Gut Microbes
Human microbiota form a biofilm with substantial consequences for health and disease. Numerous studies have indicated that microbial communities produce functional amyloids as part of their biofilm extracellular scaffolds.
Jaione Valle
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source