Results 31 to 40 of about 3,255,404 (222)

The Cryo-EM structures of two amphibian antimicrobial cross-β amyloid fibrils

Nature Communications, 2022
In this work the authors provide high-resolution structural support for the amyloid-antimicrobial link via functional amyloids displaying propeller-like and kinked cross-β fibrils.
Robert Bücker, Carolin Seuring, Cornelia Cazey, Katharina Veith, Maria García-Alai, Kay Grünewald, Meytal Landau   +6 more
doaj   +1 more source

Amyloid properties of the yeast cell wall protein Toh1 and its interaction with prion proteins Rnq1 and Sup35

Prion, 2019
Amyloids are non-branching fibrils that are composed of stacked monomers stabilized by intermolecular β-sheets. Some amyloids are associated with incurable diseases, whereas others, functional amyloids, regulate different vital processes.
A.V. Sergeeva, J.V. Sopova, T.A. Belashova, V.A. Siniukova, A.V. Chirinskaite, A.P. Galkin, S.P. Zadorsky   +6 more
doaj   +1 more source

The Poly-Histidine Tag H6 Mediates Structural and Functional Properties of Disintegrating, Protein-Releasing Inclusion Bodies

Pharmaceutics, 2022
The coordination between histidine-rich peptides and divalent cations supports the formation of nano- and micro-scale protein biomaterials, including toxic and non-toxic functional amyloids, which can be adapted as drug delivery systems.
Julieta María Sánchez, José Vicente Carratalá, Naroa Serna, Ugutz Unzueta, Verónica Nolan, Alejandro Sánchez-Chardi, Eric Voltà-Durán, Hèctor López-Laguna, Neus Ferrer-Miralles, Antonio Villaverde, Esther Vazquez   +10 more
doaj   +1 more source

Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation.

PLoS Biology, 2016
Amyloids are ordered protein aggregates that are typically associated with neurodegenerative diseases and cognitive impairment. By contrast, the amyloid-like state of the neuronal RNA binding protein Orb2 in Drosophila was recently implicated in memory ...
Rubén Hervás, Liying Li, Amitabha Majumdar, María Del Carmen Fernández-Ramírez, Jay R Unruh, Brian D Slaughter, Albert Galera-Prat, Elena Santana, Mari Suzuki, Yoshitaka Nagai, Marta Bruix, Sergio Casas-Tintó, Margarita Menéndez, Douglas V Laurents, Kausik Si, Mariano Carrión-Vázquez   +15 more
doaj   +1 more source

Good Amyloid, Bad Amyloid-What's the Difference? [PDF]

PLoS Biology, 2016
Why do some amyloids cause serious neurodegenerative diseases, while others have important biological functions? A new study of the functional amyloid Orb2 suggests that it's all about speed. Read the Research Article.
Roland G Roberts
doaj   +1 more source

Blocking Serum Amyloid-P Component from Binding to Macrophages and Augmenting Fungal Functional Amyloid Increases Macrophage Phagocytosis of Candida albicans

Pathogens, 2022
Candida-macrophage interactions are important immune defense responses associated with disseminated and deep-seated candidiasis in humans. Cells of Candida spp.
Stephen A. Klotz, Nicole Bradley, Peter N. Lipke   +2 more
doaj   +1 more source

Functional Amyloids Used by Organisms::A Lesson in Controlling Assembly

, 2010
Amyloid has been studied primarily in relation to the disease states that it causes in humans, but in recent years, a range of proteins have been identified that self-assemble to a β-sheet rich fold as part of their native function and as such have been ...
SCHEIBEL, T, Andrew M. Smith, Smith, Andrew, Thomas Scheibel   +3 more
core   +1 more source

Soluble Assemblies in the Fibrillation Pathway of Prion-Inspired Artificial Functional Amyloids are Highly Cytotoxic

, 2020
Amyloids are associated with human disease. However, they are also exploited by nature for functional purposes. Functional amyloids have inspired amyloid-based biomaterials for different nanotechnologies. Early soluble species in the fibrillation pathway
Marta Díaz-Caballero (5333633), Salvador Ventura (39268), Susanna Navarro (602004), Salvador Ventura, Marta Díaz-Caballero, Susanna Navarro   +5 more
core   +1 more source

Half a century of amyloids: past, present and future [PDF]

, 2020
Amyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. This dire situation calls for research into the origin and pathological manifestations of amyloidosis to stimulate continued ...
Riek, Roland, Knowles, Tuomas P. J., Thomas P Davis (13672042), Roland Riek (39957), Raffaele Mezzenga (837455), Hamley, Ian W., Otzen, Daniel Erik, Zhou, Ruhong, Ehud Gazit (231491), Davis, Thomas P., Ian W Hamley (16261298), Marcus Fändrich (54216), Ke, Pu Chun, Mezzenga, Raffaele, Pu Chun Ke (456097), Tuomas P J Knowles (16288028), Ruhong Zhou (277621), Dobson, Christopher M., Eisenberg, David S., Christopher M Dobson (16062884), Lashuel, Hilal A., Matthew R Chapman (16288031), David S Eisenberg (16288034), Serpell, Louise C., Louise Serpell (4461124), Gazit, Ehud, Fändrich, Marcus, Chapman, Matthew R., Knowles, Tuomas P.J., Hilal A Lashuel (16077305), Daniel Erik Otzen (430591)   +30 more
core   +2 more sources

Bacterial Amyloids

, 2019
Amyloids are supramolecular protein assemblies based on fibrillar arrangements of β- sheets that were first found as linked to neurodegenerative and systemic human diseases.
Arluison, Véronique, Rosalba Lagos, Lagos, Rosalba, Marcoleta, Andrés, Wien, Frank, Andrés Marcoleta, Giraldo, R., Frank Wien, Véronique Arluison, Rafael Giraldo   +9 more
core   +1 more source