Amyloids — a functional coat for microorganisms [PDF]
Nature Reviews Microbiology, 2005 Amyloids are filamentous protein structures approximately 10 nm wide and 0.1-10 mum long that share a structural motif, the cross-beta structure. These fibrils are usually associated with degenerative diseases in mammals. However, recent research has shown that these proteins are also expressed on bacterial and fungal cell surfaces.
Gebbink, M.F.B.G. +4 more
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Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology [PDF]
Chemical Society Reviews, 2017 Self-assembled peptide and protein amyloid nanostructures have traditionally been considered only as pathological aggregates implicated in human neurodegenerative diseases. In more recent times, these nanostructures have found interesting applications as
Arosio, Paolo +6 more
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Functional Amyloids in Adhesion of Non-albicans Candida Species [PDF]
PathogensCandida fungal species are the most common fungal opportunistic pathogens. Their ability to form antifungal resistant biofilms contributes to their increasing clinical frequency.
Melissa C. Garcia-Sherman +4 more
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Functional amyloids in bacteria [PDF]
International microbiology : the official journal of the Spanish Society for Microbiology, 2014 The term amyloidosis is used to refer to a family of pathologies altering the homeostasis of human organs. Despite having a name that alludes to starch content, the amyloid accumulations are made up of proteins that polymerize as long and rigid fibers ...
Diego Romero, Roberto Kolter
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Fold modulating function: Bacterial toxins to functional amyloids [PDF]
Frontiers in Microbiology, 2014 Many bacteria produce cytolytic toxins that target host cells or other competing microbes. It is well known that environmental factors control toxin expression, however recent work suggests that some bacteria manipulate the fold of these protein toxins ...
Adnan Khawaja Syed, Blaise R Boles
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The Role of Functional Amyloids in Multicellular Growth and Development of Gram-Positive Bacteria. [PDF]
Biomolecules, 2017 Amyloid fibrils play pivotal roles in all domains of life. In bacteria, these fibrillar structures are often part of an extracellular matrix that surrounds the producing organism and thereby provides protection to harsh environmental conditions. Here, we
Dragoš A, Kovács ÁT, Claessen D.
europepmc +6 more sources
Evolutionary insight into the functional amyloids of the pseudomonads. [PDF]
PLoS ONE, 2013 Functional bacterial amyloids (FuBA) are important components in many environmental biofilms where they provide structural integrity to the biofilm, mediate bacterial aggregation and may function as virulence factor by binding specifically to host cell ...
Morten S Dueholm +2 more
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Peptide detection of fungal functional amyloids in infected tissue. [PDF]
PLoS ONE, 2014 Many fungal cell adhesion proteins form functional amyloid patches on the surface of adhering cells. The Candida albicans Agglutinin-like sequence (Als) adhesins are exemplars for this phenomenon, and have amyloid forming sequences that are conserved ...
Melissa C Garcia-Sherman +6 more
doaj +2 more sources
The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid [PDF]
Advanced ScienceAmyloids, once viewed solely as pathological hallmarks, are now recognized as widespread and versatile functional protein assemblies. Bacterial functional amyloids (FuBAs), particularly curli (CsgA) from Escherichia coli and FapC from Pseudomonas, have ...
Samuel Peña‐Díaz +12 more
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Functional amyloids from bacterial biofilms - structural properties and interaction partners. [PDF]
Chem Sci, 2022 Akbey Ü, Andreasen M.
europepmc +2 more sources