Results 81 to 90 of about 3,444,674 (308)

Transcription factor TFE3 enhances cell cycle and cancer progression by binding to the hTERT promoter

Cancer Communications, 2021
Beiping Miao, Chaoyang Zhang, Nadine Stroh, Lukas Brenner, Katrin Hufnagel, Jörg D. Hoheisel, Obul Reddy Bandapalli   +6 more
doaj   +1 more source

Thrombomodulin is a stronger indicator of combined oral contraceptives-induced activated protein C pathway resistance in the thrombin generation test than activated protein C

Frontiers in Cardiovascular Medicine
BackgroundThe mechanism by which combined oral contraceptives (COCs) lead to hypercoagulation is not fully understood, although activated protein C (APC) pathway resistance has been implicated.
Marisa Ninivaggi, Lily Sokolova, Lily Sokolova, Demy Donkervoort, Bas de Laat, Bas de Laat, Romy de Laat-Kremers   +6 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

SOME EMBEDDINGS RELATED TO HOMOGENEOUS TRIEBEL–LIZORKIN SPACES AND THE BMO FUNCTIONS

Проблемы анализа
As the homogeneous Triebel–Lizorkin space $\dot{F}_{p,q}^s$ and the space BMO are defined modulo polynomials and constants, respectively, we prove that BMO coincides with the realized space of $\dot{F}_{\infty, 2}^0$ and cannot be directly identified ...
B. Gheribi, M. Moussai
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A Two Step Validation of the Performance-Based IISCA: A Trauma-Informed Functional Analysis Model [PDF]

, 2023
Joshua Jessel, Tess Fruchtman, Natasha Raghunauth-Zaman, Aaron Leyman, Felipe Magalhães Lemos, Henrique Costa Val, Monica R. Howard, Gregory P. Hanley   +7 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Stimulation-induced cytokine polyfunctionality as a dynamic concept

eLife
Cytokine polyfunctionality is a well-established concept in immune cells, especially T cells, and their ability to concurrently produce multiple cytokines has been associated with better immunological disease control and subsequent effectiveness during ...
Kevin Portmann, Aline Linder, Klaus Eyer
doaj   +1 more source

Structural and Functional Neural Alterations in Internet Addiction: A Study Protocol for Systematic Review and Meta-Analysis [PDF]

, 2023
Jun-Li Liu, Jing-Ting Sun, Hui-Lin Hu, Hao-Yuan Wang, Yun-Xi Kang, Tian-Qi Chen, Zhuhong Chen, Yu‐Xuan Shang, Yu-Ting Li, Bo Hu, Rui Liu   +10 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source