MetaLAFFA: a flexible, end-to-end, distributed computing-compatible metagenomic functional annotation pipeline [PDF]
BMC Bioinformatics, 2020 Background Microbial communities have become an important subject of research across multiple disciplines in recent years. These communities are often examined via shotgun metagenomic sequencing, a technology which can offer unique insights into the ...
Alexander Eng +2 more
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Genome-wide functional annotation of variants: a systematic review of state-of-the-art tools, techniques and resources [PDF]
Frontiers in PharmacologyThe recent advancement of sequencing technologies marks a significant shift in the character and complexity of the digital genomic data universe, encompassing diverse types of molecular data, screened through manifold technological platforms. As a result,
Eleftherios Pilalis +7 more
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CNAScope: pan-cancer copy number aberration database with functional annotation and interactive visualization. [PDF]
Nucleic Acids ResFeng X +7 more
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Evaluation of genomic selection models using whole genome sequence data and functional annotation in Belgian Blue cattle [PDF]
Genetics Selection EvolutionBackground The availability of large cohorts of whole-genome sequenced individuals, combined with functional annotation, is expected to provide opportunities to improve the accuracy of genomic selection (GS).
Can Yuan +6 more
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Toll-like receptor signaling in vertebrates: Testing the integration of protein, complex, and pathway data in the Protein Ontology framework [PDF]
, 2015 The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes.
Arighi, Cecilia +7 more
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Student biocuration projects as a learning environment [version 2; peer review: 2 approved]
F1000Research, 2022 Background: Bioinformatics is becoming an essential tool for the majority of biological and biomedical researchers. Although bioinformatics data is exploited by academic and industrial researchers, limited focus is on teaching this area to undergraduates,
Ruth C. Lovering +2 more
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Capturing heart valve development with Gene Ontology
Frontiers in Genetics, 2023 Introduction: The normal development of all heart valves requires highly coordinated signaling pathways and downstream mediators. While genomic variants can be responsible for congenital valve disease, environmental factors can also play a role. Later in
Saadullah H. Ahmed +4 more
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GOing Forward With the Cardiac Conduction System Using Gene Ontology
Frontiers in Genetics, 2022 The cardiac conduction system (CCS) comprises critical components responsible for the initiation, propagation, and coordination of the action potential. Aberrant CCS development can cause conduction abnormalities, including sick sinus syndrome, accessory
Kan Yan Chloe Li +3 more
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Insights into Online microRNA Bioinformatics Tools
Non-Coding RNA, 2023 MicroRNAs (miRNAs) are members of the small non-coding RNA family regulating gene expression at the post-transcriptional level. MiRNAs have been found to have critical roles in various biological and pathological processes.
Diana Luna Buitrago +2 more
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BMC Genomics, 2021 Background Functional genome annotation is the process of labelling functional genomic regions with descriptive information. Manual curation can produce higher quality genome annotations than fully automated methods.
Matthew R. Lueder +6 more
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