Results 61 to 70 of about 759,413 (161)

The Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in \u3cem\u3eC. elegans\u3c/em\u3e [PDF]

, 2016
The regulation of fundamental aspects of neurobiological function has been linked to the ubiquitin signaling system (USS), which regulates the degradation and activity of proteins and is catalyzed by E1, E2, and E3 enzymes. The Anaphase-Promoting Complex
Jennings, Alexandra K., Kowalski, Jennifer R., Wang, Julia   +2 more
core   +3 more sources

Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress in vivo

iScience
Summary: Transcription factor EB (TFEB) is a key transcription factor that orchestrates the cellular response to stress. Dysregulation of TFEB is associated with a range of human diseases, and understanding the regulatory mechanisms of TFEB is crucial ...
Juan A. Garcia-Sanchez, Estelle Bonnet, Céline Loubatier, Anne Doye, Guillaume Paillier, Fabien Segui, Frédéric Larbret, Paul Chaintreuil, Ludovic Batistic, Cédric Torre, Marcel Deckert, Jolanta Polanowska, Patrick Munro, Laurent Boyer, Orane Visvikis   +14 more
doaj   +1 more source

GeneFishing to reconstruct context specific portraits of biological processes. [PDF]

, 2019
Rapid advances in genomic technologies have led to a wealth of diverse data, from which novel discoveries can be gleaned through the application of robust statistical and computational methods.
Ashuach, Tal, Bickel, Peter J, Dose, Andrea C, Huang, Haiyan, Liu, Ke, Medina, Marisa W, Theusch, Elizabeth, Zhou, Yun   +7 more
core   +1 more source

The matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner

iScience
Summary: The matricellular protein Fibulin-5 (Fbln5) is a secreted protein that is essential for elastic fiber formation, and pancreatic islets are usually surrounded by the extracellular matrix (ECM), which includes elastic fibers.
Tomoko Okuyama, Takahiro Tsuno, Ryota Inoue, Setsuko Fukushima, Mayu Kyohara, Anzu Matsumura, Daisuke Miyashita, Kuniyuki Nishiyama, Yusuke Takano, Yu Togashi, Makiko Meguro-Horike, Shin-ichi Horike, Tatsuya Kin, A.M. James Shapiro, Hiromi Yanagisawa, Yasuo Terauchi, Jun Shirakawa   +16 more
doaj   +1 more source

Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER

iScience, 2022
Summary: Uncoupling protein 2 (UCP2), a mitochondrial protein, is known to be upregulated in pancreatic islets of patients with type 2 diabetes (T2DM); however, the pathological significance of this increase in UCP2 expression is unclear.
Ryota Inoue, Takahiro Tsuno, Yu Togashi, Tomoko Okuyama, Aoi Sato, Kuniyuki Nishiyama, Mayu Kyohara, Jinghe Li, Setsuko Fukushima, Tatsuya Kin, Daisuke Miyashita, Yusuke Shiba, Yoshitoshi Atobe, Hiroshi Kiyonari, Kana Bando, A.M. James Shapiro, Kengo Funakoshi, Rohit N. Kulkarni, Yasuo Terauchi, Jun Shirakawa   +19 more
doaj   +1 more source

Developmental biology of wood formation [PDF]

, 2003
The wood-forming vascular cambium is responsible for the production of a large part of the biomass on this planet. Yet, there is only limited knowledge on how cell proliferation and differentiation in the cambial meristem are regulated.
Schrader, Jarmo
core  

FXR in bone metabolism: An emerging regulator

iScience
Summary: Farnesoid X receptor (FXR), a core regulator of bile acid metabolism, is also a key modulator of bone metabolism that influences bone remodeling by regulating osteoblast and osteoclast activities.
S. M. Mahamudul Hassan Rizvi, Aihemaiti Shami, Yun Kan, Shengxiang Tao, Hui Liu   +4 more
doaj   +1 more source

Bridging the gap between omics and earth system science to better understand how environmental change impacts marine microbes [PDF]

, 2015
The advent of genomic-, transcriptomic- and proteomic-based approaches has revolutionized our ability to describe marine microbial communities, including biogeography, metabolic potential and diversity, mechanisms of adaptation, and phylogeny and ...
Alexander, Allen, Alvain, Ashworth, Baas-Becking, Bach, Barton, Behrenfeld, Behrenfeld, Behrenfeld, Bennett, Bihan, Bochdanovits, Bopp, Bowler, Boyd, Boyd, Boyle, Bruggeman, Buitenhuis, Buitenhuis, Buitenhuis, Button, Chappell, Coesel, Coleman, Collins, Corellou, Daines, Davis, Delong, Derelle, Deutsch, Dinsdale, Djouani-Tahri el, Doney, Draghi, Dufresne, Dutkiewicz, Edwards, Elena, Fabris, Follows, Follows, Franklin, Ghiglione, Gilbert, Gould, Hartmann, Hashioka, Hickman, Hillebrand, Hindle, Hof, Hood, House, Hutchins, Huysman, Hüner, Johnson, Juhas, Juranek, Kashtan, Kim, Kiorboe, Knoop, Kroeker, Krumholz, Ladau, Lanfear, Langer, Laws, Ley, Lindell, Litchman, Litchman, Loeuille, Lohbeck, Luo, Marchetti, Marinov, Martiny, Masotti, McKew, Mock, Monnier, Monteiro, Moore, Moulager, O'Neill, Oschlies, Patel, Piotrowski, Plummer, Poloczanaska, Quere, Raes, Ral, Raven, Raven, Raymond, Reed, Ridgwell, Riley, Rocap, Saito, Schaum, Schlichting, Schmidt, Shuter, Smetacek, Sorokina, Steuer, Stramma, Talmy, Taucher, Taylor, Thomas, Toseland, Traylor-Knowles, Troein, Vallino, Veluchamy, Via, Vogt, Vu, Webb, Wecker, Wijffels, Zinser   +129 more
core   +1 more source

Bridging Physics and Biology Teaching through Modeling [PDF]

, 2013
As the frontiers of biology become increasingly interdisciplinary, the physics education community has engaged in ongoing efforts to make physics classes more relevant to life sciences majors.
Anne-Marie Hoskinson, Benjamin M. Zwickl, Brewer Carol A., Brian A. Couch, Brooker R., Chabay R. W., Cummings K., Etkina E., Giancoli D. C., Halloun I. A., Kathleen A. Hinko, Knight R. D., Levins R., Marcos D. Caballero, National Research Council, National Research Council, National Research Council, National Research Council, National Science Board, Raven P., Reece J. B., Rice J., Serway R. A., Starfield A. M.   +23 more
core   +3 more sources

RNA interference in marine and freshwater sponges [PDF]

, 2011
Background: The marine sponge Tethya wilhelma and the freshwater sponge Ephydatia muelleri are emerging model organisms to study evolution, gene regulation, development, and physiology in non-bilaterian animal systems. Thus far, functional methods (i.e.,
Cieniewicz, Brandon, Danka, Elizabeth S., Haen, Karri M., Hammel, Jörg U., Hill, April L., Hill, Malcolm S., Knight, Scott W., Lavrov, Dennis V., Nickel, Michael, Posfai, Dora, Rivera, Ajna S., Winters, Ian P., Wörheide, Gert   +12 more
core   +1 more source