Results 61 to 70 of about 765,092 (159)

The matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner

iScience
Summary: The matricellular protein Fibulin-5 (Fbln5) is a secreted protein that is essential for elastic fiber formation, and pancreatic islets are usually surrounded by the extracellular matrix (ECM), which includes elastic fibers.
Tomoko Okuyama, Takahiro Tsuno, Ryota Inoue, Setsuko Fukushima, Mayu Kyohara, Anzu Matsumura, Daisuke Miyashita, Kuniyuki Nishiyama, Yusuke Takano, Yu Togashi, Makiko Meguro-Horike, Shin-ichi Horike, Tatsuya Kin, A.M. James Shapiro, Hiromi Yanagisawa, Yasuo Terauchi, Jun Shirakawa   +16 more
doaj   +1 more source

Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER

iScience, 2022
Summary: Uncoupling protein 2 (UCP2), a mitochondrial protein, is known to be upregulated in pancreatic islets of patients with type 2 diabetes (T2DM); however, the pathological significance of this increase in UCP2 expression is unclear.
Ryota Inoue, Takahiro Tsuno, Yu Togashi, Tomoko Okuyama, Aoi Sato, Kuniyuki Nishiyama, Mayu Kyohara, Jinghe Li, Setsuko Fukushima, Tatsuya Kin, Daisuke Miyashita, Yusuke Shiba, Yoshitoshi Atobe, Hiroshi Kiyonari, Kana Bando, A.M. James Shapiro, Kengo Funakoshi, Rohit N. Kulkarni, Yasuo Terauchi, Jun Shirakawa   +19 more
doaj   +1 more source

Evolving more efficient digital circuits by allowing circuit layout evolution and multi-objective fitness [PDF]

, 1999
We use evolutionary search to design combinational logic circuits. The technique is based on evolving the functionality and connectivity of a rectangular array of logic cells whose dimension is defined by the circuit layout.
Kalganova, T, Miller, J
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Bridging the gap between omics and earth system science to better understand how environmental change impacts marine microbes [PDF]

, 2015
The advent of genomic-, transcriptomic- and proteomic-based approaches has revolutionized our ability to describe marine microbial communities, including biogeography, metabolic potential and diversity, mechanisms of adaptation, and phylogeny and ...
Alexander, Allen, Alvain, Ashworth, Baas-Becking, Bach, Barton, Behrenfeld, Behrenfeld, Behrenfeld, Bennett, Bihan, Bochdanovits, Bopp, Bowler, Boyd, Boyd, Boyle, Bruggeman, Buitenhuis, Buitenhuis, Buitenhuis, Button, Chappell, Coesel, Coleman, Collins, Corellou, Daines, Davis, Delong, Derelle, Deutsch, Dinsdale, Djouani-Tahri el, Doney, Draghi, Dufresne, Dutkiewicz, Edwards, Elena, Fabris, Follows, Follows, Franklin, Ghiglione, Gilbert, Gould, Hartmann, Hashioka, Hickman, Hillebrand, Hindle, Hof, Hood, House, Hutchins, Huysman, Hüner, Johnson, Juhas, Juranek, Kashtan, Kim, Kiorboe, Knoop, Kroeker, Krumholz, Ladau, Lanfear, Langer, Laws, Ley, Lindell, Litchman, Litchman, Loeuille, Lohbeck, Luo, Marchetti, Marinov, Martiny, Masotti, McKew, Mock, Monnier, Monteiro, Moore, Moulager, O'Neill, Oschlies, Patel, Piotrowski, Plummer, Poloczanaska, Quere, Raes, Ral, Raven, Raven, Raymond, Reed, Ridgwell, Riley, Rocap, Saito, Schaum, Schlichting, Schmidt, Shuter, Smetacek, Sorokina, Steuer, Stramma, Talmy, Taucher, Taylor, Thomas, Toseland, Traylor-Knowles, Troein, Vallino, Veluchamy, Via, Vogt, Vu, Webb, Wecker, Wijffels, Zinser   +129 more
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Complementary approaches to understanding the plant circadian clock [PDF]

, 2010
Circadian clocks are oscillatory genetic networks that help organisms adapt to the 24-hour day/night cycle. The clock of the green alga Ostreococcus tauri is the simplest plant clock discovered so far.
A. Aziz, A. Duguid, A. Hinton, Bio-PEPA Home Page, C. Baier, Carl Troein, D. Gonze, D.T. Gillespie, E. Derelle, E.M. Clarke, Emanuela Merelli, F. Ciocchetta, F. Corellou, H. Li, H.L.S. Younes, J. Heath, J.C. Dunlap, J.S. O'Neill, L. Loewe, L. Loewe, Laurence Loewe, M.A. Jones, Maria Luisa Guerriero, O.E. Akman, O.E. Akman, Ozgur E. Akman, Paola Quaglia   +26 more
core   +4 more sources

FXR in bone metabolism: An emerging regulator

iScience
Summary: Farnesoid X receptor (FXR), a core regulator of bile acid metabolism, is also a key modulator of bone metabolism that influences bone remodeling by regulating osteoblast and osteoclast activities.
S. M. Mahamudul Hassan Rizvi, Aihemaiti Shami, Yun Kan, Shengxiang Tao, Hui Liu   +4 more
doaj   +1 more source

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 [PDF]

, 2014
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as ‘accidental cell death’ (ACD).
A Ciechanover, A Criollo, A Degterev, A Degterev, A Degterev, A Gross, A Hochreiter-Hufford, A Kaczmarek, A Linkermann, A Linkermann, A Linkermann, A Linkermann, A Nagasaka, A Oberst, A Oberst, A Pogrebniak, A Rebbaa, A Strasser, A Villunger, AA Fatokun, AA Mailleux, AC Schinzel, AD Dam, AG Fraser, AJ Schile, AM Chinnaiyan, AM Chinnaiyan, AM Choi, AM Verhagen, AU Lindner, AV Vaseva, B D Dynlacht, B Joseph, B La Scola, B La Scola, B Levine, B R Stockwell, B Zhivotovsky, B Zhivotovsky, BA Gibson, BB Wolf, BH Han, C Borner, C Brenner, C Brenner, C Brenner, C Brenner, C Du, C Garrido, C Garrido, C López-Otín, C M Rodrigues, C Munoz-Pinedo, C Muñoz-Pinedo, C Scaffidi, C Scheller, C Volbracht, C Volbracht, CM Haynes, CO Bellamy, CP Baines, CP Baines, CP Dillon, D Adam, D Andrews, D C Rubinsztein, D Chandra, D Denton, D Denton, D Denton, D Denton, D Denton, D E Bredesen, D Grander, D J Klionsky, D R Green, D Raoult, D Ren, D Vercammen, D Vercammen, D Vercammen, D Xue, D Zhu, DA Fruman, DC Rubinsztein, DE Bredesen, DJ Klionsky, DL Berry, DL Vaux, DM Moujalled, DM Moujalled, DM Underhill, DR Green, DR Green, DV Krysko, DV Krysko, DW Zhang, E Basso, E Candi, E F Wagner, E H Baehrecke, E H Cheng, E Laane, E Lugli, E Murphy, E Noch, E S Alnemri, E Tasdemir, E White, E White, EA Minina, EA Slee, EA Slee, EH Baehrecke, EJ Park, F Basit, F Cecconi, F Cecconi, F Gonzalvez, F K Chan, F Madeo, F Pietrocola, F Verrier, FC Kischkel, FH Igney, G A Rabinovich, G Denecker, G Hajnoczky, G Kroemer, G Kroemer, G Kroemer, G Kroemer, G Kroemer, G Kroemer, G Kroemer, G Lettre, G M Fimia, G Marino, G Melino, G Nuñez, G Szabadkai, G Trichonas, G Van Loo, GP Sims, H Gronemeyer, H Ichijo, H Kanuka, H Kenis, H Khalil, H Kim, H L Tang, H Pearson, H Puthalakath, H Puthalakath, H Puthalakath, H Varma, H Wajant, H Walczak, H Walczak, H Wang, H Yoshida, H Zhu, H Zou, H-U Simon, HI Roach, HL Tang, HL Tang, I Amelio, I Martinou, I Vitale, IK Poon, IP Nezis, J A Cidlowski, J E Chipuk, J H Prehn, J Hitomi, J J Lemasters, J Li, J M Abrams, J M Bravo-San Pedro, J M Hardwick, J M Penninger, J Michels, J P Medema, J Sosna, J Wu, J Yang, J Yuan, J Yuan, J Zhao, J-C Marine, J-C Martinou, JA Rickard, JC Reed, JE Chipuk, JE Chipuk, JE Vince, JF Kerr, JG Albeck, JG Albeck, JH Shin, JJ Lemasters, JL Luo, JM Hardwick, JM Murphy, JS Long, JU Schweichel, JW Upton, K Bianchi, K Blomgren, K Kehe, K Kuida, K Kuida, K Miyazaki, K Newton, K Nihira, K Prabhakaran, K Richter, K S Ravichandran, K Segawa, K Tracy, K-M Debatin, KA Spriggs, KC Zimmermann, KN Alavian, KR Knight, L Altucci, L Duprez, L Galluzzi, L Galluzzi, L Galluzzi, L Galluzzi, L Galluzzi, L Galluzzi, L Galluzzi, L Galluzzi, L Galluzzi, L Mondragon, L Steinhart, L Sun, L Zitvogel, LC Gomes, M Ankarcrona, M Annicchiarico-Petruzzelli, M Arundine, M Bonora, M Campanella, M Campanella, M Chautan, M D'Amelio, M E Peter, M Elgendy, M Endres, M Irmler, M J Bertrand, M Leist, M Los, M MacFarlane, M Mediavilla-Varela, M Muzio, M O Hengartner, M Okada, M Overholtzer, M Piacentini, M V Blagosklonny, M Woo, M-L Gougeon, MA Burguillos, MA Hughes, MA Mellen, MA Mellen, MA O'Donnell, MB Jensen, MC Wei, ME Peter, MJ Bertrand, ML Coleman, N Di Daniele, N G Bazan, N Holler, N Honarpour, N Mizushima, N Mizushima, N S Chandel, N Tavernarakis, N Vanlangenakker, N Vanlangenakker, N Vanlangenakker, NJ Curtin, NJ McCarthy, NN Danial, O Kepp, O Kepp, O Krysko, P Bouillet, P Golstein, P J Jost, P Kraft, P Li, P Mazzarello, P Meier, P Nicotera, P Nicotera, P Pacher, P Pinton, P Saikumar, P Schotte, P Vandenabeele, P Vandenabeele, P Vandenabeele, P Vandenabeele, PE Czabotar, PG Clarke, PJ Jost, PS Brookes, Q Remijsen, Q Zhang, R A Flavell, R A Knight, R A Lockshin, R De Maria, R Hakem, R Rashmi, R Rizzuto, R Skouta, R Weinlich, RA Lockshin, RA Lockshin, RC Taylor, RJ O'Brien, RM del Moral, RU Janicke, RW Oppenheim, S A Aaronson, S A Lipton, S Barut, S Bhattacharyya, S Dolma, S Enzenmuller, S Fulda, S Fulda, S Grootjans, S He, S J Martin, S Jouan-Lanhouet, S Kumar, S Kumar, S Melino, S Morioka, S Renolleau, S Tan, S Vallabhapurapu, S W Tait, S Zelenay, SA Lakhani, SA Susin, SB Bratton, SC Chow, SJ Dixon, SJ Dixon, SJ Kim, SJ Martin, SJ Martin, SM Knoblach, SM Laster, SM Srinivasula, SN Willis, SW Tait, SW Tait, SW Tait, SW Tait, SW Tait, SW Yu, SW Yu, SY Chen, T Hirsch, T Ide, T Kaufmann, T Lindsten, T M Dawson, T Nakagawa, T Nakamura, T Panaretakis, T Rudel, T Tenev, T Vanden Berghe, T Vanden Berghe, T Vanden Berghe, T Vanden Berghe, T Vanden Berghe, TG Cotter, TJ Daish, TJ Fan, TM Caserta, U Moll, V De Laurenzi, V Giorgio, V Gogvadze, V L Dawson, V Labi, V M Dixit, V Nikoletopoulou, W Fiers, W G Wood, W Han, W Han, W Hou, W Malorni, W S El-Deiry, W Zhang, WJ Kaiser, WJ Kaiser, WS Yang, WW Chen, X Chen, X Li, X Liu, X Luo, X Pan, XM Yin, Y Ben-Neriah, Y Dondelinger, Y Dondelinger, Y Eguchi, Y Fuchs, Y Li, Y Liu, Y Rong, Y Shi, Y Tsujimoto, Y Wang, Y Zaltsman, YP Ow, YS Cho, Z Cai, Z Song, Z Wang, Z Zakeri, ZA Dunai   +438 more
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Molecular and cellular mechanisms underlying the evolution of form and function in the amniote jaw. [PDF]

, 2019
The amniote jaw complex is a remarkable amalgamation of derivatives from distinct embryonic cell lineages. During development, the cells in these lineages experience concerted movements, migrations, and signaling interactions that take them from their ...
A Abzhanov, A Abzhanov, A Abzhanov, A Baggiolini, A Baroffio, A Beverdam, A Chevallier, A Davidian, A del Rio, A Graham, A Graham, A Hosseini, A Rinon, A Roycroft, A Sharir, A Shellard, A Subramanian, AA Pitsillides, AE Adams, AE Merrill, AG Robling, AG Robling, AH Jheon, AJ Hughes, AL Romanoff, AL Tavares, ALP Tavares, AM Bailleul, AM Bailleul, AM Lucas, AS Pollard, AS Romer, AS Romer, AS Tucker, AS Tucker, AW Crompton, AW Crompton, B Christ, B McBratney-Owen, B Ruhin, BA Moore-Scott, BD Matthews, BF Eames, BF Eames, BF Kingsbury, BK Hall, BK Hall, BK Hall, BK Hall, BK Hall, BK Hall, BK Hall, BK Hall, BK Hall, BK Hall, BK Hall, BL Pruitt, C Attanasio, C Gans, C Gegenbaur, C Holliday, C Mitgutsch, C Patterson, C Reichert, CI Lorda-Diez, CL Hammond, CS Le Lievre, CS Le Lièvre, CT Miller, CV Baker, CV Baker, CW Benkman, CW Benkman, D Hu, D Hu, D Hu, D Hu, D Noden, DD Davis, DE Clouthier, DG Wilkinson, DJ Evans, DL Stemple, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DR Carter, DR Cordero, E Berthet, E Blitz, E Blitz, E Dupin, E Gaupp, E Jarvik, E Theveneau, E Tzahor, E Tzahor, E Zelzer, EC Olesnicky Killian, EF Allin, EL Ealba, EM Sefton, EP Allis, EP Allis, EP Allis, ER Lankester, ES Goodrich, ES Goodrich, ES Russell, F Lescroart, F Liu, FJ Smith, FL Landacre, FV Jotereau, FW Chamberlain, G Andres, G Balooch, G Couly, G Couly, G Couly, G Kardon, G Kardon, G Köntges, G Wagner, G Zweers, GA Zweers, GA Zweers, GA Zweers, GB Muller, GF Couly, GF Couly, GM Morriss-Kay, GR de Beer, GR de Beer, GR de Beer, H Vinkka, HB Shaffer, HJ Chong, HL Hamilton, HL Szabo-Rogers, HP Shih, I Bothe, I Raizman, I Rot-Nikcevic, J Apostolakos, J Fang, J Grenier, J Hall, J Jeong, J Kahn, J Ruberte, J Stutzmann, JA Helms, JB Gross, JB Platt, JF Webb, JJ Baumel, JJ Schoenebeck, JJ Schoenebeck, JL Chang, JL Fish, JL Fish, JL Fish, JL Fish, JM Brito, JM Richman, JM Tabler, JN Thompson, JP Golding, JR Merida-Velasco, JR Merida-Velasco, JR Robbins, JS Kingsley, JW Kingsbury, K Hayashi, K Sheehan-Rooney, K Yasui, KC Woronowicz, KC Wu, KE Haworth, KJ Lamb, KK Smith, KK Smith, KK Smith, KK Smith, KS Thomson, KW Li, KW Tosney, L LeResche, L Olsson, L Ramage, LB Ruest, LS Gammill, LS Stone, LS Stone, M Bancroft, M Benjamin, M Bronner-Fraser, M Bronner-Fraser, M Hoso, M Jollie, M Jollie, M Jollie, M Jollie, M Linde-Medina, M Minoux, M Persson, M Qiu, M Qiu, M Sieber-Blum, M Simoes-Costa, M Takechi, M Tokita, M Tokita, MA Selleck, MA Shkoukani, MAJ Selleck, MJ Depew, MJ Depew, MJ Depew, MJ Depew, ML Martik, ML Moss, ML Moss, MM Dawson, MM Smith, MM Smith, MN Spyropoulos, MR Sanchez-Villagra, MR Sánchez-Villagra, MS Tyler, MSY Lee, N Anthwal, N Anthwal, N Anthwal, N Wang, NC Jones, NJ Giori, NM Young, NM Young, NN Soni, NS Bradley, O Campas, O Rieppel, OP Hamill, P Betancur, P Danaisawadi, P Hunt, P Kissel, P Kulesa, P Murray, P Murray, P Thorogood, P Wu, P Wu, PA Trainor, PA Trainor, PA Trainor, PA Trainor, PA Trainor, PA Trainor, PA Trainor, PD Henion, PDF Murray, PH Francis-West, PS Verma, PY Lwigale, R Cerny, R Derynck, R Diogo, R Luo, R Mallarino, R McBeath, R McLennan, R McLennan, R Owen, R Owen, R Presley, R Presley, R Sambasivan, R Sambasivan, R Schweitzer, RA Schneider, RA Schneider, RA Schneider, RA Schneider, RA Schneider, RA Schneider, RA Schneider, RA Schneider, RA Schneider, RA Yuodelis, RC Garcez, RC Mootoosamy, RC Solem, RG Harrison, RG Northcutt, RG Northcutt, RJ Gorlin, RL Carroll, RL Zusi, RW Oppenheim, RW Oppenheim, RW Oppenheim, RW Shufeldt, S Alappat, S Amin, S Creuzet, S Dupont, S Ekanayake, S Hörstadius, S Kavumpurath, S Krispin, S Kuraku, S Kuratani, S Kuratani, S Kuratani, S Kuratani, S Kuratani, S Kuratani, S Kuratani, S Lamichhaney, S Lautenschlager, S Lautenschlager, S Murakami, S Shibata, S Tajbakhsh, S Thomopoulos, S Wadhwa, SC Ahlgren, SC Ahlgren, SH Lee, SH Reynolds, SJ Gould, SJ Mathew, SL Horowitz, SL Prescott, SL Washburn, SR Roberts, SW Herring, T Hems, T Hirasawa, T Kantomaa, T Maeda, T Mammoto, T Matsuoka, T Miyashita, T Rowe, T Sato, T Sauka-Spengler, T Sauka-Spengler, T Square, T Thomas, T Yoshida, TA Appel, TA Mitsiadis, TA Mitsiadis, TC Fitzgerald, TE Parsons, TG Boyd, TH Huxley, TH Huxley, TL Vincent, V Govindarajan, V Hamburger, V Hamburger, V Shone, VL Naples, W Maier, WA Beresford, WA Beresford, WE Reif, WF Van den Heuvel, WG Hall, WJ Moore, WJ Moore, WK Parker, WM McLeod, X Jiang, X Li, XL Tu, Y Hashimoto, Y Shigetani, Y Shigetani, Y Shwartz, Y Song, Y Sugimoto   +395 more
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P-cadherin-dependent adhesions are required for single lumen formation and HGF-mediated cell protrusions during epithelial morphogenesis

iScience
Summary: During epithelial morphogenesis, in vivo, epithelial cells form cysts enclosing a single, hollow lumen and extend protrusions as a precursor for tubulogenesis.
Sydnie K. Tran, Jessanne Y. Lichtenberg, Corinne E. Leonard, Jessica R. Williamson, Hazel R. Sterling, Grace K. Panek, Amanda H. Pearson, Santiago Lopez, Christopher A. Lemmon, Daniel E. Conway, Priscilla Y. Hwang   +10 more
doaj   +1 more source

RNA interference in marine and freshwater sponges [PDF]

, 2011
Background: The marine sponge Tethya wilhelma and the freshwater sponge Ephydatia muelleri are emerging model organisms to study evolution, gene regulation, development, and physiology in non-bilaterian animal systems. Thus far, functional methods (i.e.,
Cieniewicz, Brandon, Danka, Elizabeth S., Haen, Karri M., Hammel, Jörg U., Hill, April L., Hill, Malcolm S., Knight, Scott W., Lavrov, Dennis V., Nickel, Michael, Posfai, Dora, Rivera, Ajna S., Winters, Ian P., Wörheide, Gert   +12 more
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