Results 71 to 80 of about 759,413 (161)

P-cadherin-dependent adhesions are required for single lumen formation and HGF-mediated cell protrusions during epithelial morphogenesis

open access: yesiScience
Summary: During epithelial morphogenesis, in vivo, epithelial cells form cysts enclosing a single, hollow lumen and extend protrusions as a precursor for tubulogenesis.
Sydnie K. Tran   +10 more
doaj   +1 more source

Molecular and cellular mechanisms underlying the evolution of form and function in the amniote jaw. [PDF]

open access: yes, 2019
The amniote jaw complex is a remarkable amalgamation of derivatives from distinct embryonic cell lineages. During development, the cells in these lineages experience concerted movements, migrations, and signaling interactions that take them from their ...
A Abzhanov   +395 more
core   +1 more source

Transcriptome analysis of porcine M. semimembranosus divergent in intramuscular fat as a consequence of dietary protein restriction [PDF]

open access: yes, 2013
peer-reviewedBackground: Intramuscular fat (IMF) content is positively correlated with aspects of pork palatability, including flavour, juiciness and overall acceptability.
Aslan, Ozlem   +6 more
core   +1 more source

Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity

open access: yesiScience
Summary: In addition to the degradation of cell-cycle proteins, short-lived, damaged, or unfolded proteins are constantly cleared from cells by the proteasome.
Gabriel Ruiz-Romero   +4 more
doaj   +1 more source

A mathematical system for human implantable wound model studies [PDF]

open access: yes, 2017
In this work, we present a mathematical model, which accounts for two fundamental processes involved in the repair of an acute dermal wound. These processes include the inflammatory response and fibroplasia.
Paul-Michael, Salomonsky, Segal, Rebecca
core   +1 more source

Fission yeast Bgs1 glucan synthase participates in the control of growth polarity and membrane traffic

open access: yesiScience
Summary: Rod-shaped fission yeast grows through cell wall expansion at poles and septum, synthesized by essential glucan synthases. Bgs1 synthesizes the linear β(1,3)glucan of primary septum at cytokinesis. Linear β(1,3)glucan is also present in the wall
Mariona Ramos   +11 more
doaj   +1 more source

The physics of epigenetics

open access: yes, 2016
In higher organisms, all cells share the same genome, but every cell expresses only a limited and specific set of genes that defines the cell type. During cell division, not only the genome, but also the cell type is inherited by the daughter cells. This
Barbi, Maria   +6 more
core   +3 more sources

Penfluridol targets septin7 to suppress endometrial cancer by septin7-Orai/IP3R-Ca2+-PIK3CA pathway

open access: yesiScience
Summary: Phenotypic screening of existing drugs is a good strategy to discover new drugs. Herein, 33 psychotherapeutic drugs in our drug library were screened by phenotypic screening and penfluridol (PFD) was found to exhibit excellent anti-endometrial ...
Lingyi Song   +12 more
doaj   +1 more source

Computational analysis of the LRRK2 interactome. [PDF]

open access: yes, 2015
LRRK2 was identified in 2004 as the causative protein product of the Parkinson's disease locus designated PARK8. In the decade since then, genetic studies have revealed at least 6 dominant mutations in LRRK2 linked to Parkinson's disease, alongside one ...
Denny, P   +3 more
core  

JNK signaling coordinates epithelial cell turnover through exocytosis in Drosophila ribosomal protein mutants

open access: yesiScience
Summary: Robust tissue growth is orchestrated by the precise coordination of cell death and cell proliferation. In the developing wing pouches of Drosophila Minute/+ animals, both cell death and compensatory cell proliferation are increased, thereby ...
Nanami Akai   +3 more
doaj   +1 more source

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