Results 71 to 80 of about 765,092 (159)

The Evolution of Cell Communication: The Road not Taken. [PDF]

, 2009
In the post-genomic era the complex problem of evolutionary biology can be tackled from the top-down, the bottom-up, or from the middle-out. Given the emergent and contingent nature of this process, we have chosen to take the latter approach, both as a ...
Rehan, VK, Torday, JS
core   +1 more source

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards [PDF]

, 2016
Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune ...
Brandau, Sven, Bronte, Vincenzo, Chen, Shu Hsia, Colombo, Mario P, Frey, Alan B, Gabrilovich, Dmitry I., Greten, Tim F, Mandruzzato, Susanna, Murray, Peter J, Ochoa, Augusto, Ostrand Rosenberg, Suzanne, Rodriguez, Paulo C, Sica, Antonio, Umansky, Viktor, Vonderheide, Robert H   +14 more
core   +2 more sources

The ASD Living Biology: from cell proliferation to clinical phenotype. [PDF]

, 2019
Autism spectrum disorder (ASD) has captured the attention of scientists, clinicians and the lay public because of its uncertain origins and striking and unexplained clinical heterogeneity.
Courchesne, Eric, Gazestani, Vahid H, Lewis, Nathan E, Lombardo, Michael V, Pierce, Karen, Pramparo, Tiziano   +5 more
core  

A human MAP kinase interactome. [PDF]

, 2010
Mitogen-activated protein kinase (MAPK) pathways form the backbone of signal transduction in the mammalian cell. Here we applied a systematic experimental and computational approach to map 2,269 interactions between human MAPK-related proteins and other ...
A Friedman, A Karydis, A Lunardi, AA Reszka, AC Gavin, AJ Whitmarsh, BP Kelley, C Widmann, Chih-yuan Chiang, Christopher H Martin, Cornelia Kurschner, D Wang, Diane L Barber, DJ LaCount, GD Bader, GL Johnson, J Kim, J Ptacek, JV Olsen, Jyoti Srivastava, K Hayashi, K Venkatesan, KC Gunsalus, L Chang, L Collin, M Baumgartner, M Karin, M Qi, M Rothe, Merril Gersten, Mike Smoot, P Uetz, PJ Cullen, R Hooley, R Konig, R Konig, R Konig, Russell Bell, S Peri, SA Johnson, SK Chanda, Sourav Bandyopadhyay, SP Denker, Sudhir Sahasrabudhe, Suhaila White, Sumit K Chanda, T Ito, T Reguly, Trey Ideker, W Kolch, W Kolch, Y Ho   +51 more
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Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity

iScience
Summary: In addition to the degradation of cell-cycle proteins, short-lived, damaged, or unfolded proteins are constantly cleared from cells by the proteasome.
Gabriel Ruiz-Romero, María Dolores Berdún, Mark Hochstrasser, Silvia Salas-Pino, Rafael R. Daga   +4 more
doaj   +1 more source

STEM materials: a new frontier for an intelligent sustainable world [PDF]

, 2019
Materials are addressed as possible enablers for solutions to many global societal challenges. A foresight exercise has been conducted to identify research paths to design, with a new approach, a generation of materials which can provide multi ...
B Alberts, G Vladilo, K Lejaeghere, M Newman, PL Luisi, S Mann, S Mayue, S Tibbits, SC Warren, WR Stahel, XA Zhang   +10 more
core   +1 more source

The physics of epigenetics

, 2016
In higher organisms, all cells share the same genome, but every cell expresses only a limited and specific set of genes that defines the cell type. During cell division, not only the genome, but also the cell type is inherited by the daughter cells. This
Barbi, Maria, Caré, Bertrand R., Cortini, Ruggero, Lavelle, Christophe, Lesne, Annick, Mozziconacci, Julien, Victor, Jean-Marc   +6 more
core   +3 more sources

Fission yeast Bgs1 glucan synthase participates in the control of growth polarity and membrane traffic

iScience
Summary: Rod-shaped fission yeast grows through cell wall expansion at poles and septum, synthesized by essential glucan synthases. Bgs1 synthesizes the linear β(1,3)glucan of primary septum at cytokinesis. Linear β(1,3)glucan is also present in the wall
Mariona Ramos, Rebeca Martín-García, M. Ángeles Curto, Laura Gómez-Delgado, M. Belén Moreno, Mamiko Sato, Elvira Portales, Masako Osumi, Sergio A. Rincón, Pilar Pérez, Juan C. Ribas, Juan C.G. Cortés   +11 more
doaj   +1 more source

Computational analysis of the LRRK2 interactome. [PDF]

, 2015
LRRK2 was identified in 2004 as the causative protein product of the Parkinson's disease locus designated PARK8. In the decade since then, genetic studies have revealed at least 6 dominant mutations in LRRK2 linked to Parkinson's disease, alongside one ...
Denny, P, Lewis, PA, Lovering, RC, Manzoni, C   +3 more
core  

Complex networks theory for analyzing metabolic networks

, 2006
One of the main tasks of post-genomic informatics is to systematically investigate all molecules and their interactions within a living cell so as to understand how these molecules and the interactions between them relate to the function of the organism,
A. B. Horne, A. Bairoch, A. Broder, A. L. Barabasi, A. L. Barabasi, A. Samal, A. Wagner, B. M. Bakker, C. H. Schilling, C. Wagner, D. J. Watts, E. Ravasz, H. Jeong, H. Kitano, H. Lipson, H. W. Ma, H. W. Ma, H. W. Ma, Hong Yu, J. A. Papin, J. C. M. Mombach, J. Gagneur, J. Stelling, J. Stelling, Jianhua Luo, Jing Zhao, L. H. Hartwell, M. Arita, M. C. Palumbo, M. Faloutsos, M. Kanehisa, M. Kanehisa, M. Nakao, M. V. Martinov, N. Lemke, P. D. Karp, P. D. Karp, P. Erdös, P. Holme, R. Albert, R. Guimera, R. Mahadevan, R. Overbeek, R. Schuster, S. Goto, S. Schuster, S. Schuster, S. Wuchty, Yixue Li, Z. N. Oltvai, Z. W. Cao   +50 more
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