Results 71 to 80 of about 178,723 (265)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Annales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2019 Report from the conference.
Report of Meeting
doaj
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Existence of positive solutions of linear delay difference equations with continuous time
Electronic Journal of Qualitative Theory of Differential Equations, 2015 Consider the delay difference equation with continuous time of the form \[x(t)-x(t-1)+\sum_{i=1}^mP_i(t)x(t-k_i(t))=0,\qquad t\ge t_0,\] where $P_i\colon[t_0,\infty)\mapsto\mathbb{R}$, $k_i\colon[t_0,\infty)\mapsto \{2,3,4,\dots\}$ and $\lim_{t\to\infty}(
George Chatzarakis +3 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Renormalization group functional equations
Physical Review D, 2011 Functional conjugation methods are used to analyze the global structure of various renormalization group trajectories, and to gain insight into the interplay between continuous and discrete rescaling. With minimal assumptions, the methods produce continuous flows from step-scaling functions, and lead to exact functional relations for the local flow
Curtright, Thomas L., Zachos, Cosmas K.
openaire +3 more sources
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
A Certain Functional Equation [PDF]
Results in Mathematics, 1998 By a simpler argument than that used by \textit{H. Haruki} [Aequationes Math. 36, No. 1, 1-19 (1988; Zbl 0656.39004)], the author determines all entire functions \(f\), \(g\), \(h\) and \(k\) satisfying the functional equation \(|f(z+ w)|+|g(z- w)|= |h(z+ w)|+ |k(z- w)|\).
openaire +2 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source