Results 81 to 90 of about 535,935 (302)

Multi-objective improvement of software using co-evolution and smart seeding [PDF]

, 2008
Optimising non-functional properties of software is an important part of the implementation process. One such property is execution time, and compilers target a reduction in execution time using a variety of optimisation techniques. Compiler optimisation
Abbass, H, Arcuri, Andrea, Branke, JR, Ciesielski, V, Clark, J, Deb, K, Green, D, Hendtlass, T, Kirley, M, Li, X, Michalewicz, Z, Shi, Y, Tan, KC, White, DR, Yao, Xin, Zhang, M   +15 more
core   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Measuring the Impact of COVID-19 on Young Adult Functional Capacity: A Comparative Study of Walking and Step Endurance Tests

Physical Education Theory and Methodology
Objectives. This study aimed to evaluate and compare the functional capacity of young adults recovering from COVID-19 using the 6-Minute Walk Test (6MWT) and 2-Minute Step Test (2MST), focusing on cardiovascular parameters, and to examine correlations ...
Patchareeya Amput, Arunrat Srithawong, Sinthuporn Maharan, Puttipong Poncumhak, Patcharin Phrompao, Eakarach Wongsaya, Tichanon Promsrisuk, Sahachat Aueyingsak   +7 more
doaj   +1 more source

Large-effect flowering time mutations reveal conditionally adaptive paths through fitness landscapes in Arabidopsis thaliana. [PDF]

, 2019
Contrary to previous assumptions that most mutations are deleterious, there is increasing evidence for persistence of large-effect mutations in natural populations.
Cooper, Martha D, Roe, Judith L, Runcie, Daniel E, Schmitt, Johanna, Taylor, Mark A, Welch, Stephen M, Wilczek, Amity M   +6 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Aptidão física funcional de idosos praticantes de hidroginástica

Revista Brasileira de Geriatria e Gerontologia
O estudo teve como objetivo verificar a aptidão física funcional de idosos praticantes de hidroginástica. A amostra foi constituída por 18 mulheres idosas, com idade média de 65,5±5,84 praticantes das aulas de hidroginástica do Centro de Excelência em ...
Rui Gonçalves Marques Elias, Eliane Cristina de Andrade Gonçalves, Augusto César Ferreira de Moraes, Cibelly Formaggio Moreira, Carlos Alexandre Molena Fernandes   +4 more
doaj   +1 more source

High-Intensity Interval Circuit Training Versus Moderate-Intensity Continuous Training on Functional Ability and Body Mass Index in Middle-Aged and Older Women: A Randomized Controlled Trial [PDF]

, 2019
The literature suggests that high-intensity interval training (HIIT) is more effective than moderate-intensity continuous training (MICT) to improve functional ability. However, there is no evidence on including HIIT in a circuit programme (HIICT).
Ballesta-García, Ismael, Carrasco Poyatos, María, Martínez González-Moro, Ignacio, Rubio Arias, Jacobo Á.   +3 more
core   +1 more source

How objective are biological functions? [PDF]

, 2017
John Searle has argued that functions owe their existence to the value that we put into life and survival. In this paper, I will provide a critique of Searle’s argument concerning the ontology of functions.
Weber, Marcel
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source