Results 81 to 90 of about 535,015 (301)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Aptidão física funcional de idosos praticantes de hidroginástica

Revista Brasileira de Geriatria e Gerontologia
O estudo teve como objetivo verificar a aptidão física funcional de idosos praticantes de hidroginástica. A amostra foi constituída por 18 mulheres idosas, com idade média de 65,5±5,84 praticantes das aulas de hidroginástica do Centro de Excelência em ...
Rui Gonçalves Marques Elias, Eliane Cristina de Andrade Gonçalves, Augusto César Ferreira de Moraes, Cibelly Formaggio Moreira, Carlos Alexandre Molena Fernandes   +4 more
doaj   +1 more source

Evolutionary connectionism: algorithmic principles underlying the evolution of biological organisation in evo-devo, evo-eco and evolutionary transitions [PDF]

, 2015
The mechanisms of variation, selection and inheritance, on which evolution by natural selection depends, are not fixed over evolutionary time. Current evolutionary biology is increasingly focussed on understanding how the evolution of developmental ...
A Clark, A Crombach, A Davies, A Mesoudi, A Traulsen, A Wagner, A Wagner, Adam Davies, Adam Jackson, AF Bourke, AG Jones, B Gallardo, B Matthews, BE Beisner, C Folke, C. L. Buckley, CA Solari, Chris Cox, CP Doncaster, CR Shalizi, CS Holling, D Schluter, D Simberloff, Daniel Power, DC Queller, DE Rumelhart, DH Ackley, DJ Earl, DM Post, DO Hebb, DS Wilson, DS Wilson, DS Wilson, E Chastain, E Jablonka, E Jablonka, E Jablonka, E Szathmáry, E Szathmáry, EG Leigh, FC Poderoso, FC Santos, FM Bator, G Bateson, G O’Toole, G Ritzer, GB Müller, GC Gallopín, GE Hinton, GE Hinton, GE Hinton, GP Wagner, GP Wagner, GP Wagner, GP Wagner, H Lipson, HE Hoekstra, J Clune, J Draghi, J Gerhart, J Maynard Smith, J Maynard Smith, J Maynard Smith, J Maynard Smith, J Odling-Smee, J Odling-Smee, JD Farmer, JF Fontanari, JH Lawton, JJ Hopfield, JJ Hopfield, JJ Hopfield, JL Hendrikse, JM Montoya, JM Pacheco, JN Thompson, JP Wright, JR Snowdon, K Jax, K Laland, K Sigmund, KN Laland, KN Laland, KN Laland, Kostas Kouvaris, L Margulis, L Margulis, L Margulis, L Partridge, L Valiant, Loizos Kounios, LW Buss, M Blute, M Chicurel, M Gell-Mann, M Hauschild, M Kallich, M Kirchner, M Parter, M Pavlicev, M Pelikan, M Pigliucci, M Pigliucci, M Pigliucci, M Toussaint, M Trestman, MA Nowak, MJ West-Eberhard, ML Johnson, MO Jackson, MO Jackson, N Kashtan, N Kashtan, P Godfrey-Smith, PD Sniegowski, PM Brakefield, R Amundson, R Cropp, R Levins, R Mills, R Riedl, RA Watson, RA Watson, RA Watson, RA Watson, RA Watson, RA Watson, RC Lewontin, RC O’Reilly, RE Michod, RE Michod, RE Michod, RE Michod, Richard A. Watson, Rob Mills, S Huang, S Okasha, S Okasha, S Segbroeck Van, SA Frank, SA Frank, SA Frank, SA Levin, SA Levin, SB Carroll, Simon T. Powers, Simon Tudge, SJ Arnold, ST Powers, T Dayan, T Mitchell, TM Lenton, TM Lenton, TW Schoener, W Ghang, WL Brown, WR Ashby   +156 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The evolution of complex gene regulation by low specificity binding sites

, 2012
Transcription factor binding sites vary in their specificity, both within and between species. Binding specificity has a strong impact on the evolution of gene expression, because it determines how easily regulatory interactions are gained and lost ...
Plotkin, Joshua B., Stewart, Alexander J.   +1 more
core   +1 more source

Directed enzyme evolution: climbing fitness peaks one amino acid at a time [PDF]

, 2009
Directed evolution can generate a remarkable range of new enzyme properties. Alternate substrate specificities and reaction selectivities are readily accessible in enzymes from families that are naturally functionally diverse.
Arnold, Frances H., Tracewell, Cara A.
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Silesians in Texas and Upper Silesia: anthropometric, functional and physical activity characteristics

Anthropological Review, 2020
Anthropometric, functional and physical activity characteristics of contemporary adult descendants of Upper Silesian immigrants to Texas in the mid-19th century and current residents in Upper Silesia were compared.
Rożek-Piechura Krystyna, Ignasiak Zofia, Kurzaj Monika, Sławinska Teresa, Skrzek Anna, Kozieł Sławomir, Malina Robert M   +6 more
doaj   +1 more source

Circuit layout evolution: An evolvable hardware approach [PDF]

, 1999
The evolvable hardware technique is based on evolving the functionality and connectivity of a rectangular array of logic cells in addition to the layout of this may. The evolutionary process contains two main steps.
Kalganova, T, Miller, J F
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source