Results 61 to 70 of about 68,679 (255)

Ageing under unequal circumstances: a cross-sectional analysis of the gender and socioeconomic patterning of functional limitations among the Southern European elderly

International Journal for Equity in Health, 2017
Background In a context of population ageing, it is a priority for planning and prevention to understand the socioeconomic (SE) patterning of functional limitations and its consequences on healthcare needs.
Manuel Serrano-Alarcón, Julian Perelman
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Age patterns of racial/ethnic/nativity differences in disability and physical functioning in the United States

Demographic Research, 2014
Background: Rapid population aging and increasing racial/ethnic and immigrant/native diversity make a broad documentation of U.S. health patterns during both mid- and late life particularly important.
Jennifer Melvin, Robert Hummer, Irma Elo, Neil Mehta   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Sociodemographic moderators of the association between functional limitations and depressive symptoms among Chinese older adults

Frontiers in Psychiatry
IntroductionDepressive symptoms among older adults are a growing public health concern, particularly in rapidly aging populations like China. Functional limitations, commonly experienced with advancing age, have been shown to exacerbate depressive ...
Haijun Hao, Haijun Hao, Junyue Yue, Yeong Hun Yeo   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Impact of Orthodontic Aligner Treatment on Oral Health-Related Quality of Life

Journal of Pharmacy and Bioallied Sciences
Background: Orthodontic aligners have gained popularity due to their aesthetic appeal and convenience compared to traditional braces. Materials and Methods: One hundred patients (aged 18 to 30 years) receiving aligner-assisted orthodontic treatment ...
Kabir Suman Dash, Osric DCosta, Ashwini Dhopte, Shivani Kumari, Mrunal Dave, Hiroj Bagde, Mahesh Ghadage, Dipooja Patil, Ramanpal Singh Makkad   +8 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Vitamin D status is associated with functional limitations and functional decline in older individuals.

, 2013
Context: Vitamin D is known to influence muscle health. A reduction in muscle mass increases the risk of functional limitations among older individuals.
Visser, M., Deeg, D.J.H., van Schoor, N.M., Visser, M.; id_orcid, de Jongh, R.T., Lips, P., Sohl, E.   +6 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source