Results 71 to 80 of about 68,679 (255)

Construct validity of self-reported and interview-guided administration methods of the Danish version of the post-COVID−19 functional Status scale

Frontiers in Rehabilitation Sciences
IntroductionThe Post-COVID-19 Functional Status (PCFS) scale was quickly adopted into COVID-19 research and clinical practice worldwide to monitor functional status and recovery.
Lotte Sørensen, Jane Agergaard, Jane Agergaard, Trine Brøns Nielsen, Trine Brøns Nielsen, Berit Schiøttz-Christensen, Berit Schiøttz-Christensen, Cecilia Hee Laursen, Cecilia Hee Laursen, Cecilia Hee Laursen, Steffen Leth, Steffen Leth, Claus Vinther Nielsen, Claus Vinther Nielsen, Claus Vinther Nielsen, Lisa Gregersen Oestergaard, Lisa Gregersen Oestergaard   +16 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Functional limitations and loneliness in middle-aged and older adults: differentiating emotional loneliness and social loneliness

BMC Public Health
Background People with functional limitations may be lonelier than those without functional limitations, as health-related constraints can restrict social participation.
Johannes Beller, Julia Graßhoff, Stefanie Sperlich   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A descriptive correlation of medication and dietary compliance beliefs with functional limitations in heart failure patients

, 2000
In order to determine the existence of a relationship between heart failure patients\u27 compliance beliefs and functional limitations, using a convenience sample of 61 adults attending a specialized outpatient heart failure clinic, responses to scale ...
Diener, Dorothy B.
core   +1 more source

Effectiveness of Different Neurocognitive Intervention Approaches on Functionality in Healthy Older Adults: A Systematic Review

Behavioral Sciences
Subtle loss of functionality in healthy older adults is considered one of the most important predictors of cognitive decline. Neurocognitive interventions are increasingly being used, from a preventive maintenance approach to functional capacity.
Susana Sáez-Gutiérrez, Eduardo J. Fernandez-Rodriguez, Celia Sanchez-Gomez, Alberto Garcia-Martin, Luis Polo-Ferrero, Fausto J. Barbero-Iglesias   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Functional Limitations in Severe Haemophilia

, 2006
This thesis aims to describe the Disablement Process (DP) in Dutch adult patients with severe haemophilia, with specific focus on the domain of “Functional Limitations”.
Genderen, F.R. van
core  

Self-reported versus professionally assessed functional limitations in community-dwelling very old individuals

, 2012
The objective of this study was to examine the relationship between self-reported and professionally assessed functional limitations in community-dwelling very old individuals.
Nygren, Carita, Haak, Maria, Carlsson, Gunilla, Carlssona, Gunilla, Iwarsson, Susanne, Haak,Maria   +5 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source