Results 61 to 70 of about 900,963 (349)

The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate whether the rs10191329 risk allele in the DYSF–ZNF638 locus, which is implicated in central nervous system resilience rather than immune‐mediated pathology, is associated with retinal layer thinning, a biomarker of neuroaxonal damage in relapsing multiple sclerosis (RMS). Methods From a prospective observational study,
Gabriel Bsteh, Ruchi Tanavade, Nik Krajnc, Fabian Föttinger, Theresa König, Martin Krenn, Lukas Haider, Barbara Kornek, Fritz Leutmezer, Kerstin U. Ludwig, Stefan Macher, Tobias Monschein, Markus Ponleitner, Paulus Rommer, Christiane Schmied, Karin Zebenholzer, Tobias Zrzavy, Gudrun Zulehner, Franziska Di Pauli, Axel Schmidt, Harald Hegen, Berthold Pemp, Thomas Berger   +22 more
wiley   +1 more source

Alterations in static and dynamic regional homogeneity in mesial temporal lobe epilepsy with and without initial precipitating injury

Frontiers in Neuroscience, 2023
ObjectivesInitial precipitating injury (IPI) such as febrile convulsion and intracranial infection will increase the susceptibility to epilepsy. It is still unknown if the functional deficits differ between mesial temporal lobe epilepsy with IPI (mTLE ...
Xinyue Mao, Xinyue Mao, Xinyue Mao, Xinyue Mao, Xinyue Mao, Xinyue Mao, Xinyue Mao, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Chengru Song, Chengru Song, Chengru Song, Chengru Song, Chengru Song, Chengru Song, Chengru Song, Keran Ma, Keran Ma, Keran Ma, Keran Ma, Keran Ma, Keran Ma, Keran Ma, Kefan Wang, Kefan Wang, Kefan Wang, Kefan Wang, Kefan Wang, Kefan Wang, Kefan Wang, Xin Wang, Xin Wang, Xin Wang, Xin Wang, Xin Wang, Xin Wang, Xin Wang, Yajun Lian, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Yan Zhang, Yan Zhang, Yan Zhang, Yan Zhang, Yan Zhang, Yan Zhang, Yan Zhang   +70 more
doaj   +1 more source

Quantitative Iron Measurements in the Basal Ganglia of NBIA Patients Using QSM: Insights From a Tertiary Center

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurodegeneration with brain iron accumulation (NBIA) comprises rare genetic disorders characterized by predominantly extrapyramidal symptoms and iron deposition in the basal ganglia. Conventional magnetic resonance imaging (MRI) detects qualitative changes but cannot accurately quantify iron accumulation. Quantitative susceptibility
Özge Uygun, Alpay Özcan, Fuat Kaan Aras, Evrim Bozdemir, Sibel Uğur İşeri, Koray Kırımtay, Arzu Karabay, Murat Gültekin, Nihan Hande Akçakaya, Orkhan Mammadov, Gülay Kır, Dilek İnce Günal, Neşe Tuncer, Fatma Betül Özdilek, Banu Özen Barut, Ercan Köse, Hülya Apaydın, Asuman Ali, Sultan Çağırıcı, Pınar Topaloğlu, Alp Dinçer, Zuhal Yapıcı   +21 more
wiley   +1 more source

Bilateral versus Unilateral Training With Rhythmic Auditory Cueing in Stroke Rehabilitation: Effects on Upper Limb Function and Interhemispheric Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke is a leading cause of long‐term disability in adults, with upper limb hemiparesis being a common impairment. Traditional training is mostly aimed at paralyzed limbs, but the effect of bilateral training is still unclear.
Fangfang Qian, Yanhong Dai, Guoqiang Zheng, Qi Zhong, Jianliang Lu, Luying Hu, Youhua He, Zhuoming Chen   +7 more
wiley   +1 more source

Meta-analysis of structural and functional alterations of brain in patients with attention-deficit/hyperactivity disorder

Frontiers in Psychiatry, 2023
BackgroundA large and growing body of neuroimaging research has concentrated on patients with attention-deficit/hyperactivity disorder (ADHD), but with inconsistent conclusions.
Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Miaomiao Yu, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xinyu Gao, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Xiaoyu Niu, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Mengzhe Zhang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Zhengui Yang, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Shaoqiang Han, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Jingliang Cheng, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang, Yong Zhang   +55 more
doaj   +1 more source

Effects of Non‐Aspirin Nonsteroidal Anti‐Inflammatory Drugs on Acute Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite celecoxib, a cyclooxygenase‐2 inhibitor, promoting functional recovery from intracerebral hemorrhage (ICH) by reducing inflammation‐mediated perihematomal edema in rat models, the evidence of its effects on patient outcomes remains limited.
Shin‐Joe Yeh, Sung‐Chun Tang, Li‐Kai Tsai, Jiann‐Shing Jeng   +3 more
wiley   +1 more source

The recent history of afferent stimulation modulates corticospinal excitability

NeuroImage, 2022
Background: Transcranial magnetic stimulation (TMS) is widely used to probe corticospinal excitability and fast sensorimotor integration in the primary motor hand area (M1-HAND).
Marie Trolle Bonnesen, Søren Asp Fuglsang, Hartwig Roman Siebner, Lasse Christiansen   +3 more
doaj   +1 more source

Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan, Stephanie A. Chu, Suvi Häkkinen, Liwen Zhang, David McFall, Jonathan D. Rohrer, Jesse A. Brown, Alex J. Lee, Kristen Fernhoff, Lorenzo Pasquini, Katherine P. Rankin, Maria Luisa Mandelli, Maria Luisa Gorno‐Tempini, Jennifer S. Yokoyama, Virginia E. Sturm, Brian Appleby, Bradford C. Dickerson, Kimiko Domoto‐Reilly, Tatiana Foroud, Daniel H. Geschwind, Nupur Ghoshal, Neill R. Graff‐Radford, Ging‐Yuek Robin Hsiung, Eric J. Huang, Edward Huey, Kejal Kantarci, Irene Litvan, Ian R. Mackenzie, Mario F. Mendez, Chiadi U. Onyike, Leonard Petrucelli, Eliana Marisa Ramos, Erik D. Roberson, Julio C. Rojas, Maria Carmela Tartaglia, Arthur W. Toga, Sandra Weintraub, Leah K. Forsberg, Hilary W. Heuer, Brad F. Boeve, Adam L. Boxer, Howard J. Rosen, Bruce L. Miller, Fermin Moreno, William W. Seeley, Suzee E. Lee, on behalf of the ALLFTD Consortium   +46 more
wiley   +1 more source

Dynamic Relationship Between Interhemispheric Functional Connectivity and Corticospinal Tract Changing Pattern After Subcortical Stroke

Frontiers in Aging Neuroscience, 2022
Background and PurposeIncreased interhemispheric resting-state functional connectivity (rsFC) between the bilateral primary motor cortex (M1) compensates for corticospinal tract (CST) impairment, which facilitates motor recovery in chronic subcortical ...
Jingchun Liu, Caihong Wang, Jingliang Cheng, Peifang Miao, Zhen Li   +4 more
doaj   +1 more source

Single‐Cell RNA Seq in Sydenham Chorea Shows B Cell HLA‐DR/DQ Upregulation and Plasma Cell Proteasomal Activation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The pathogenesis of Sydenham chorea remains unclear. We report a 10‐year‐old girl presenting with subacute chorea and mild carditis following Streptococcal throat infection. Single‐cell RNA sequencing on 30,794 peripheral immune cells from the patient and two sex‐matched controls revealed nine immune cell clusters.
Velda X. Han, Brooke A. Keating, Brian S. Gloss, Xianzhong Lau, Ruwani Dissanayake, Hiroya Nishida, Jessica Hayes, Shrujna Patel, Shekeeb S. Mohammad, Russell C. Dale   +9 more
wiley   +1 more source