Results 91 to 100 of about 6,198,061 (298)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Modeling the variation trends of glacier systems
Лëд и снег, 2015 The basic principles and methods for a functional glacier systems model are introduced and applied for glaciers of Northwest China. When running the model we assume that a glacier system is under steady state conditions in the initial year.
Z. Xie, X. Wang, Q. Li, S. Liao, Y. Dai
doaj +1 more source
Predicting C-H/$\pi$ interactions with nonlocal density functional theory
, 2007 We examine the performance of a recently developed nonlocal density functional in predicting a model noncovalent interaction, the weak bond between an aromatic $\pi$ system and an aliphatic C-H group.
Frank Zerilli +7 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Structural - functional analysis of rolling stock repair of industrial enterprises
Nauka ta progres transportu, 2012 The analysis of the existing system repair rolling stock industry and proposed to use structural and functional models that allow to create effective communication system repairs.
M.I.Kapitza, B.E.Bodnar, R.A.Korenyuk
doaj
On the functional window of the avian compass
, 2017 The functional window is an experimentally observed property of the avian compass that refers to its selectivity around the geomagnetic field strength.
Ganguly, Swaroop +3 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
DIAGNOSIS WITH A FUNCTION-FAULT MODEL
Applied Artificial Intelligence, 1989 This paper introduces a domain model for use in diagnostic problem solving. It emphasizes functional decomposition, rather than behavior, cause-effect, or spatial structure, and represents explicitly the faults of a system together with its possible explanations.
openaire +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source