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Prognostic Value of Malnutrition, Frailty, and Physical Performance in Transthyretin Cardiac Amyloidosis: Insights From a Prospective Multicenter Cohort Study. [PDF]

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Fumagalli C, Zampieri M, Presta R, Pini G, Vetere G, Argirò A, Longhi S, Tini G, Musumeci B, Limongelli G, Palmiero G, Verrillo F, Beltrami M, Bo M, De Ferrari G, Tofani L, Sardu C, Marfella R, Marchionni N, Perfetto F, Olivotto I, Fumagalli S, Maurer MS, Fontana M, Ungar A, Cappelli F.   +25 more
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Comparison of Chlordimeform and Carbaryl Usin a Functional Observational Battery

Toxicological Sciences, 1988
The effects of the formamidine pesticide chlordimeform (CDM), and the carbamate carbaryl (CAR) were compared using a functional observational battery (FOB). The FOB, a series of observations and measurements that can be rapidly administered to toxicant-treated rats, includes home-cage and open-field observations, neuromuscular and sensorimotor tests ...
V C, Moser, J P, McCormick, J P, Creason, R C, MacPhail   +3 more
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Evaluation of Neurotoxicity Potential in Rats: The Functional Observational Battery

Current Protocols in Pharmacology, 2010
AbstractThis unit describes the functional observational battery (FOB), a behavioral screening procedure commonly used in safety pharmacology and toxicology studies to assess potentially adverse effects of test agents on the central nervous system. The battery includes general observations and the determination of reactivity to various stimuli.
Aurélie, Boucard, Anne-Marie, Bétat, Roy, Forster, Alain, Simonnard, Guillaume, Froget   +4 more
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Comparison of methods for analysis of functional observation battery (FOB) data

Journal of Pharmacological and Toxicological Methods, 2010
Different methods for the analysis of behavioral observation data were compared to evaluate how the interpretation of a data set may depend on the analysis method employed.Three methods of analysis were used to evaluate the same four sets of rodent behavioral FOB data: (1) evaluation by a trained behavioral toxicologist (ToxRev); (2) Kruskal-Wallis ...
Carrie G, Markgraf, Maria, Cirino, John, Meredith   +2 more
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Functional observation battery in nonhuman primates with continuous intracerebral infusion

Journal of Pharmacological and Toxicological Methods, 2012
A functional observation battery (FOB) is often conducted as part of the ICH S7A safety pharmacology core battery and is normally conducted in rodents but can also be performed in large animals such as non human primates when justifi ed. Intracerebral infusion is used in patients for delivery of therapeutic agents for treatment of serious brain ...
Simon Authier, Jean-Guy Bienvenu, Robert Tavcar, Sebastien Fournier, Anneliese Schneider, Karen Wong   +5 more
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Functional observational battery comparing effects of ethanol, 1,1,1-trichloroethane, ether, and flurothyl

Neurotoxicology and Teratology, 1996
Several recent reports have demonstrated that acute solvent exposure in animals produces a profile of neurobehavioral effects similar to that of classical CNS depressant drugs such as the barbiturates and ethanol. The present investigation further delineated the behavioral pharmacology of three solvents [1,1,1-trichloroethane (TCE), ether, and ...
S E, Bowen, J L, Wiley, E B, Evans, M E, Tokarz, R L, Balster   +4 more
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A Functional Observational Battery for Use in Canine Toxicity Studies: Development and Validation

International Journal of Toxicology, 2003
The most commonly used nonrodent species in regulatory toxicity and safety assessment studies has been and remains the dog, with the beagle being the standard breed employed. Although a standard functional observational battery (FOB) or neurobehavioral screen for use in rodents (primarily rats) has been incorporated into rodent studies since the late ...
S C, Gad, S E, Gad
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A functional observational battery in non-human primates for regulatory-required neurobehavioral assessments

Journal of Pharmacological and Toxicological Methods, 2008
The objective of this study was to establish a functional observational battery that provided a basic neurological and behavioral assessment fully compliant with requisite governmental regulatory guidelines.Accredited Laboratory Animal Technicians (ALAT) were trained to conduct neurobehavioral assessments in rhesus monkeys prior to and following ...
David V, Gauvin, Theodore J, Baird
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