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Journal of Pharmacological and Toxicological Methods, 2009
The objective of this study was to describe an optimised neurobehavioural observation battery in the beagle dog and to demonstrate that it can be used for an integrated assessment of cardiovascular and neurobehavioural functions within a single Safety Pharmacology study.A standardised and detailed observation battery was established based on the direct
MOSCARDO, ELENA +4 more
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The objective of this study was to describe an optimised neurobehavioural observation battery in the beagle dog and to demonstrate that it can be used for an integrated assessment of cardiovascular and neurobehavioural functions within a single Safety Pharmacology study.A standardised and detailed observation battery was established based on the direct
MOSCARDO, ELENA +4 more
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Screening Approaches to Neurotoxicity: A Functional Observational Battery
Journal of the American College of Toxicology, 1989Observational tests to assess the behavioral and neurologic integrity of laboratory rats have been advanced for use in the primary screening of chemicals to detect neurotoxic potential. To examine the use of such an approach, we are systematically using a functional observational battery (FOB) to characterize known neurotoxicants and to assess its ...
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Design of Functional Interval Observers for a Battery and Motor Circuit Model of Electric Vehicle
2019 IEEE Vehicle Power and Propulsion Conference (VPPC), 2019In this paper we first establish a model of battery and motor circuit for electric vehicle (EV). We then consider the problem of estimating linear functions of the state vector of this model. We design two novel observers to estimate the set of admissible values for linear functions of the state vector at each instant of time.
Dinh Cong Huong +2 more
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CNS Adverse Effects: From Functional Observation Battery/Irwin Tests to Electrophysiology
2015This chapter describes various approaches for the preclinical assessment of drug-induced central nervous system (CNS) adverse effects. Traditionally, methods to evaluate CNS effects have consisted of observing and scoring behavioral responses of animals after drug is administered. Among several behavioral testing paradigms, the Irwin and the functional
Carlos, Fonck +3 more
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Toxicology and Applied Pharmacology, 1991
A functional observational battery (FOB) was utilized to assess the effects of 3-day exposure to the formamidine pesticide amitraz in outbred Sprague-Dawley-derived and inbred Fischer-344-derived (F344) rats (both from Charles River Laboratories) and in outbred Long-Evans rats obtained from two commercial suppliers (Charles River Breeding Laboratories ...
V C, Moser, K L, McDaniel, P M, Phillips
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A functional observational battery (FOB) was utilized to assess the effects of 3-day exposure to the formamidine pesticide amitraz in outbred Sprague-Dawley-derived and inbred Fischer-344-derived (F344) rats (both from Charles River Laboratories) and in outbred Long-Evans rats obtained from two commercial suppliers (Charles River Breeding Laboratories ...
V C, Moser, K L, McDaniel, P M, Phillips
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Functional Observation Battery Test for Single Intravenous Caffeine Exposure in Male ICR Mice
Journal of Medicinal FoodThis study investigated the behavioral responses of male Institute for Cancer Research (ICR) mice to intravenous caffeine exposure via a functional observation battery (FOB) test. Thirty-two experimental mice were randomly assigned to four groups (n = 8 per group) and received intravenous caffeine at a dose of 0, 5, 10, or 20 mg/kg.
Sung-Hyun Cho +3 more
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Journal of the American College of Toxicology, 1989
Screening tests for detecting the presence or probable absence of a single end point (such as neurobehavioral activity) are the most common and important activities in toxicology. Objectives and characteristics of screens are presented and reviewed here, and the corresponding essential design features of a neurotoxicology screen are suggested.
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Screening tests for detecting the presence or probable absence of a single end point (such as neurobehavioral activity) are the most common and important activities in toxicology. Objectives and characteristics of screens are presented and reviewed here, and the corresponding essential design features of a neurotoxicology screen are suggested.
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The FASEB Journal, 2016
The nervous system is one of the most complex organs in the body, and has its unique vulnerabilities to toxic compounds.
Alain Stricker‐Krongrad +5 more
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The nervous system is one of the most complex organs in the body, and has its unique vulnerabilities to toxic compounds.
Alain Stricker‐Krongrad +5 more
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The functional observational battery in adult and developing rats.
Neurotoxicology, 2001Neurobehavioral screening methods, such as the functional observational battery (FOB), are now widely used to identify potential neurotoxicity of new and existing chemicals. These methods have been validated and a large database now exists for the effects of a wide range of chemicals.
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Toxicological Sciences, 1991
A Functional observational battery (FOB) was utilized to provide a semiquantitative description of the hyperreactivity, excitability, and debilitation produced by amitraz. Adult male Long-Evans rats were administered either vehicle or 10, 25, 50, 100, or 200 mg/kg amitraz ip.
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A Functional observational battery (FOB) was utilized to provide a semiquantitative description of the hyperreactivity, excitability, and debilitation produced by amitraz. Adult male Long-Evans rats were administered either vehicle or 10, 25, 50, 100, or 200 mg/kg amitraz ip.
openaire +2 more sources