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Toxicology and Applied Pharmacology, 2005
Two tests, a functional observational battery (FOB) and measurement of motor activity, have been used to screen the two NHE inhibitors EMD 96785 and EMD 125021 for neurobehavioral effects. These two NHE inhibitors, which exhibit a marked selectivity for the NHE 1 isoform, are under development in the research laboratories of Merck KGaA.
Marion Hewicker-Trautwein
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Two tests, a functional observational battery (FOB) and measurement of motor activity, have been used to screen the two NHE inhibitors EMD 96785 and EMD 125021 for neurobehavioral effects. These two NHE inhibitors, which exhibit a marked selectivity for the NHE 1 isoform, are under development in the research laboratories of Merck KGaA.
Marion Hewicker-Trautwein
exaly +3 more sources
Screening Approaches to Neurotoxicity: A Functional Observational Battery
Journal of the American College of Toxicology, 1989Observational tests to assess the behavioral and neurologic integrity of laboratory rats have been advanced for use in the primary screening of chemicals to detect neurotoxic potential. To examine the use of such an approach, we are systematically using a functional observational battery (FOB) to characterize known neurotoxicants and to assess its ...
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Design of Functional Interval Observers for a Battery and Motor Circuit Model of Electric Vehicle
2019 IEEE Vehicle Power and Propulsion Conference (VPPC), 2019In this paper we first establish a model of battery and motor circuit for electric vehicle (EV). We then consider the problem of estimating linear functions of the state vector of this model. We design two novel observers to estimate the set of admissible values for linear functions of the state vector at each instant of time.
Dinh Cong Huong +2 more
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CNS Adverse Effects: From Functional Observation Battery/Irwin Tests to Electrophysiology
2015This chapter describes various approaches for the preclinical assessment of drug-induced central nervous system (CNS) adverse effects. Traditionally, methods to evaluate CNS effects have consisted of observing and scoring behavioral responses of animals after drug is administered. Among several behavioral testing paradigms, the Irwin and the functional
Carlos, Fonck +3 more
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Toxicology and Applied Pharmacology, 1991
A functional observational battery (FOB) was utilized to assess the effects of 3-day exposure to the formamidine pesticide amitraz in outbred Sprague-Dawley-derived and inbred Fischer-344-derived (F344) rats (both from Charles River Laboratories) and in outbred Long-Evans rats obtained from two commercial suppliers (Charles River Breeding Laboratories ...
V C, Moser, K L, McDaniel, P M, Phillips
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A functional observational battery (FOB) was utilized to assess the effects of 3-day exposure to the formamidine pesticide amitraz in outbred Sprague-Dawley-derived and inbred Fischer-344-derived (F344) rats (both from Charles River Laboratories) and in outbred Long-Evans rats obtained from two commercial suppliers (Charles River Breeding Laboratories ...
V C, Moser, K L, McDaniel, P M, Phillips
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Functional Observation Battery Test for Single Intravenous Caffeine Exposure in Male ICR Mice
Journal of Medicinal FoodThis study investigated the behavioral responses of male Institute for Cancer Research (ICR) mice to intravenous caffeine exposure via a functional observation battery (FOB) test. Thirty-two experimental mice were randomly assigned to four groups (n = 8 per group) and received intravenous caffeine at a dose of 0, 5, 10, or 20 mg/kg.
Sung-Hyun Cho +3 more
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Data Evaluation and Statistical Analysis of Functional Observational Battery Data Using a Linear Models Approach [PDF]
Journal of the American College of Toxicology, 1989 Statistical analysis of functional observational battery (FOB) data presents special problems in that there are three different types of data collected (continuous, count, and categorical), all of which are measured in a repeated manner across time.
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Journal of the American College of Toxicology, 1989
Screening tests for detecting the presence or probable absence of a single end point (such as neurobehavioral activity) are the most common and important activities in toxicology. Objectives and characteristics of screens are presented and reviewed here, and the corresponding essential design features of a neurotoxicology screen are suggested.
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Screening tests for detecting the presence or probable absence of a single end point (such as neurobehavioral activity) are the most common and important activities in toxicology. Objectives and characteristics of screens are presented and reviewed here, and the corresponding essential design features of a neurotoxicology screen are suggested.
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The FASEB Journal, 2016
The nervous system is one of the most complex organs in the body, and has its unique vulnerabilities to toxic compounds.
Alain Stricker‐Krongrad +5 more
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The nervous system is one of the most complex organs in the body, and has its unique vulnerabilities to toxic compounds.
Alain Stricker‐Krongrad +5 more
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Psychopharmacology, 2006
1,1,1-Trichloroethane (TCE), a representative abused solvent, has well described acute behavioral effects in animals. Much less is known about repeated high-concentration exposures as would be encountered in inhalant abusers. Tolerance has been demonstrated in some, but not all, studies with TCE while sensitization has also been seen with other abused ...
Scott E. Bowen
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1,1,1-Trichloroethane (TCE), a representative abused solvent, has well described acute behavioral effects in animals. Much less is known about repeated high-concentration exposures as would be encountered in inhalant abusers. Tolerance has been demonstrated in some, but not all, studies with TCE while sensitization has also been seen with other abused ...
Scott E. Bowen
exaly +3 more sources