Results 251 to 260 of about 4,250,676 (289)
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Comparison of Chlordimeform and Carbaryl Usin a Functional Observational Battery
Toxicological Sciences, 1988The effects of the formamidine pesticide chlordimeform (CDM), and the carbamate carbaryl (CAR) were compared using a functional observational battery (FOB). The FOB, a series of observations and measurements that can be rapidly administered to toxicant-treated rats, includes home-cage and open-field observations, neuromuscular and sensorimotor tests ...
V C, Moser +3 more
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Comparison of Chlordimeform and Carbaryl Using a Functional Observational Battery*1
Fundamental and Applied Toxicology, 1988Robert C Macphail +2 more
exaly +2 more sources
Evaluation of Neurotoxicity Potential in Rats: The Functional Observational Battery
Current Protocols in Pharmacology, 2010AbstractThis unit describes the functional observational battery (FOB), a behavioral screening procedure commonly used in safety pharmacology and toxicology studies to assess potentially adverse effects of test agents on the central nervous system. The battery includes general observations and the determination of reactivity to various stimuli.
Aurélie, Boucard +4 more
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Comparison of methods for analysis of functional observation battery (FOB) data
Journal of Pharmacological and Toxicological Methods, 2010Different methods for the analysis of behavioral observation data were compared to evaluate how the interpretation of a data set may depend on the analysis method employed.Three methods of analysis were used to evaluate the same four sets of rodent behavioral FOB data: (1) evaluation by a trained behavioral toxicologist (ToxRev); (2) Kruskal-Wallis ...
Carrie G, Markgraf +2 more
openaire +2 more sources
Journal of Pharmacological and Toxicological Methods, 2016
The International Conference on Harmonisation's (ICH) Tripartite Guideline on Safety Pharmacology Studies for Human Pharmaceuticals has adopted the requirement that each new test substance must be tested for effects on the central nervous system prior to "first dose in man".
David V Gauvin +2 more
exaly +3 more sources
The International Conference on Harmonisation's (ICH) Tripartite Guideline on Safety Pharmacology Studies for Human Pharmaceuticals has adopted the requirement that each new test substance must be tested for effects on the central nervous system prior to "first dose in man".
David V Gauvin +2 more
exaly +3 more sources
Fundamental and Applied Toxicology, 1994
The acute neurobehavioral effects of six alkylbenzenes (benzene, toluene, ethylbenzene, propylbenzene, m-xylene, and cumene) were evaluated after 20-min inhalation exposures using a functional observational battery (FOB) in mice. In order to do this, an explicit protocol for the FOB developed for rats by Moser was adapted for use in mice with ...
R L Balster
exaly +3 more sources
The acute neurobehavioral effects of six alkylbenzenes (benzene, toluene, ethylbenzene, propylbenzene, m-xylene, and cumene) were evaluated after 20-min inhalation exposures using a functional observational battery (FOB) in mice. In order to do this, an explicit protocol for the FOB developed for rats by Moser was adapted for use in mice with ...
R L Balster
exaly +3 more sources
Functional observation battery in nonhuman primates with continuous intracerebral infusion
Journal of Pharmacological and Toxicological Methods, 2012A functional observation battery (FOB) is often conducted as part of the ICH S7A safety pharmacology core battery and is normally conducted in rodents but can also be performed in large animals such as non human primates when justifi ed. Intracerebral infusion is used in patients for delivery of therapeutic agents for treatment of serious brain ...
Simon Authier +5 more
openaire +1 more source
Neurotoxicology and Teratology, 1992
The clinical effects of two neurotoxicants, acrylamide and 2,5-hexanedione, were compared in rats using a functional observational battery (FOB), which includes a series of home cage and open-field observations, sensorimotor measurements, and physiological parameters.
Ehrich Marion, B S Jortner
exaly +3 more sources
The clinical effects of two neurotoxicants, acrylamide and 2,5-hexanedione, were compared in rats using a functional observational battery (FOB), which includes a series of home cage and open-field observations, sensorimotor measurements, and physiological parameters.
Ehrich Marion, B S Jortner
exaly +3 more sources
Archives of Environmental Health, 2001
To determine whether JP-8 jet fuel affects parameters of the Functional Observational Battery (FOB), visual discrimination, or spatial learning and memory, the authors exposed groups of male Fischer Brown Norway hybrid rats for 28 d to aerosol/vapor-delivered JP-8, or to JP-8 followed by 15 min of aerosolized substance P analogue, or to sham-confined ...
Carol A. Barnes, Mark L Witten
exaly +3 more sources
To determine whether JP-8 jet fuel affects parameters of the Functional Observational Battery (FOB), visual discrimination, or spatial learning and memory, the authors exposed groups of male Fischer Brown Norway hybrid rats for 28 d to aerosol/vapor-delivered JP-8, or to JP-8 followed by 15 min of aerosolized substance P analogue, or to sham-confined ...
Carol A. Barnes, Mark L Witten
exaly +3 more sources
Journal of Pharmacological and Toxicological Methods, 2009
The objective of this study was to describe an optimised neurobehavioural observation battery in the beagle dog and to demonstrate that it can be used for an integrated assessment of cardiovascular and neurobehavioural functions within a single Safety Pharmacology study.A standardised and detailed observation battery was established based on the direct
MOSCARDO, ELENA +4 more
openaire +3 more sources
The objective of this study was to describe an optimised neurobehavioural observation battery in the beagle dog and to demonstrate that it can be used for an integrated assessment of cardiovascular and neurobehavioural functions within a single Safety Pharmacology study.A standardised and detailed observation battery was established based on the direct
MOSCARDO, ELENA +4 more
openaire +3 more sources