Results 251 to 260 of about 4,017,219 (285)
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Fundamental and Applied Toxicology, 1994
The acute neurobehavioral effects of six alkylbenzenes (benzene, toluene, ethylbenzene, propylbenzene, m-xylene, and cumene) were evaluated after 20-min inhalation exposures using a functional observational battery (FOB) in mice. In order to do this, an explicit protocol for the FOB developed for rats by Moser was adapted for use in mice with ...
R L Balster
exaly +3 more sources
The acute neurobehavioral effects of six alkylbenzenes (benzene, toluene, ethylbenzene, propylbenzene, m-xylene, and cumene) were evaluated after 20-min inhalation exposures using a functional observational battery (FOB) in mice. In order to do this, an explicit protocol for the FOB developed for rats by Moser was adapted for use in mice with ...
R L Balster
exaly +3 more sources
Archives of Environmental Health, 2001
To determine whether JP-8 jet fuel affects parameters of the Functional Observational Battery (FOB), visual discrimination, or spatial learning and memory, the authors exposed groups of male Fischer Brown Norway hybrid rats for 28 d to aerosol/vapor-delivered JP-8, or to JP-8 followed by 15 min of aerosolized substance P analogue, or to sham-confined ...
C A Barnes, Mark L Witten, M L Witten
exaly +3 more sources
To determine whether JP-8 jet fuel affects parameters of the Functional Observational Battery (FOB), visual discrimination, or spatial learning and memory, the authors exposed groups of male Fischer Brown Norway hybrid rats for 28 d to aerosol/vapor-delivered JP-8, or to JP-8 followed by 15 min of aerosolized substance P analogue, or to sham-confined ...
C A Barnes, Mark L Witten, M L Witten
exaly +3 more sources
Neurotoxicology and Teratology, 1992
The clinical effects of two neurotoxicants, acrylamide and 2,5-hexanedione, were compared in rats using a functional observational battery (FOB), which includes a series of home cage and open-field observations, sensorimotor measurements, and physiological parameters.
Marion Ehrich, B S Jortner
exaly +3 more sources
The clinical effects of two neurotoxicants, acrylamide and 2,5-hexanedione, were compared in rats using a functional observational battery (FOB), which includes a series of home cage and open-field observations, sensorimotor measurements, and physiological parameters.
Marion Ehrich, B S Jortner
exaly +3 more sources
Toxicology and Applied Pharmacology, 2005
Two tests, a functional observational battery (FOB) and measurement of motor activity, have been used to screen the two NHE inhibitors EMD 96785 and EMD 125021 for neurobehavioral effects. These two NHE inhibitors, which exhibit a marked selectivity for the NHE 1 isoform, are under development in the research laboratories of Merck KGaA.
Nicole, Hübler +4 more
exaly +3 more sources
Two tests, a functional observational battery (FOB) and measurement of motor activity, have been used to screen the two NHE inhibitors EMD 96785 and EMD 125021 for neurobehavioral effects. These two NHE inhibitors, which exhibit a marked selectivity for the NHE 1 isoform, are under development in the research laboratories of Merck KGaA.
Nicole, Hübler +4 more
exaly +3 more sources
Psychopharmacology, 2006
1,1,1-Trichloroethane (TCE), a representative abused solvent, has well described acute behavioral effects in animals. Much less is known about repeated high-concentration exposures as would be encountered in inhalant abusers. Tolerance has been demonstrated in some, but not all, studies with TCE while sensitization has also been seen with other abused ...
Scott E Bowen
exaly +3 more sources
1,1,1-Trichloroethane (TCE), a representative abused solvent, has well described acute behavioral effects in animals. Much less is known about repeated high-concentration exposures as would be encountered in inhalant abusers. Tolerance has been demonstrated in some, but not all, studies with TCE while sensitization has also been seen with other abused ...
Scott E Bowen
exaly +3 more sources
Current Protocols in Pharmacology, 2018
AbstractThe modified Irwin procedure or functional observational battery (FOB) can be used to achieve several goals. New chemical entities (NCEs) can be behaviorally screened for nervous system effects at a variety of doses to identify potential therapeutic uses and in the selection of appropriate doses for subsequent assays. NCEs can also be evaluated
Joanne R, Mathiasen, Virginia C, Moser
exaly +4 more sources
AbstractThe modified Irwin procedure or functional observational battery (FOB) can be used to achieve several goals. New chemical entities (NCEs) can be behaviorally screened for nervous system effects at a variety of doses to identify potential therapeutic uses and in the selection of appropriate doses for subsequent assays. NCEs can also be evaluated
Joanne R, Mathiasen, Virginia C, Moser
exaly +4 more sources
Comparison of chlordimeform and carbaryl using a functional observational battery*1
Fundamental and Applied Toxicology, 1988Robert C Macphail +2 more
exaly +2 more sources
Comparison of Chlordimeform and Carbaryl Usin a Functional Observational Battery
Toxicological Sciences, 1988The effects of the formamidine pesticide chlordimeform (CDM), and the carbamate carbaryl (CAR) were compared using a functional observational battery (FOB). The FOB, a series of observations and measurements that can be rapidly administered to toxicant-treated rats, includes home-cage and open-field observations, neuromuscular and sensorimotor tests ...
V C, Moser +3 more
openaire +2 more sources
Comparison of methods for analysis of functional observation battery (FOB) data
Journal of Pharmacological and Toxicological Methods, 2010Different methods for the analysis of behavioral observation data were compared to evaluate how the interpretation of a data set may depend on the analysis method employed.Three methods of analysis were used to evaluate the same four sets of rodent behavioral FOB data: (1) evaluation by a trained behavioral toxicologist (ToxRev); (2) Kruskal-Wallis ...
Carrie G, Markgraf +2 more
openaire +2 more sources
Functional observation battery in nonhuman primates with continuous intracerebral infusion
Journal of Pharmacological and Toxicological Methods, 2012A functional observation battery (FOB) is often conducted as part of the ICH S7A safety pharmacology core battery and is normally conducted in rodents but can also be performed in large animals such as non human primates when justifi ed. Intracerebral infusion is used in patients for delivery of therapeutic agents for treatment of serious brain ...
Simon Authier +5 more
openaire +1 more source