Individualized nutritional intervention combined with tailored resistance exercise in hospitalized frail older adults: A prospective, single-arm pilot before-and-after study. [PDF]
J Int Med ResChen L +5 more
europepmc +1 more source
A distributed event-triggered framework for coordinating athlete autonomic states via wearable sensor networks. [PDF]
Front PsycholWang C, Li S.
europepmc +1 more source
Development of a Functional Observational Battery in the Minipig for Regulatory Neurotoxicity Assessments [PDF]
International Journal of Toxicology, 2017 A functional observational battery (FOB) is recommended as the first-tier neurotoxicity screening in the preclinical safety pharmacology testing guidelines. Minipigs have increasingly been used in regulatory toxicology studies; however, no current FOB protocol is available for neurotoxicity testing in these species.
Alain Stricker-Krongrad
exaly +4 more sources
A Performance Standard for Clinical and Functional Observational Battery Examinations of Rats [PDF]
Journal of the American College of Toxicology, 1996 Clinical examinations are a key component of all toxicology studies and are a major component of the functional observational battery (FOB). The FOB is a core feature of the USEPA neurotoxicity screening guideline of 1991. The need for well-trained technicians is recognized, but technician competency is virtually always judged subjectively by their ...
Joel L Mattsson, Ralph R Albee
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Approaches for Assessing the Validity of a Functional Observational Battery
Neurotoxicology and Teratology, 1990As neurobehavioral assessments during the preliminary stages of chemical testing are more widely undertaken, it is critical that the screening procedures utilized be valid indicators of neurobehavioral function and that they be sensitive, specific, and reliable.
V C Moser, Virginia C Moser
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The Functional Observation Battery: Utility in Safety Assessment of New Molecular Entities
Neuromethods, 2021David V Gauvin
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The objective of this study was to establish a functional observational battery that provided a basic neurological and behavioral assessment fully compliant with requisite governmental regulatory guidelines.Accredited Laboratory Animal Technicians (ALAT) were trained to conduct neurobehavioral assessments in rhesus monkeys prior to and following ...
David V Gauvin, Theodore J Baird
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A Functional Observational Battery for Use in Canine Toxicity Studies: Development and Validation.
International Journal of Toxicology, 2003The most commonly used nonrodent species in regulatory toxicity and safety assessment studies has been and remains the dog, with the beagle being the standard breed employed. Although a standard functional observational battery (FOB) or neurobehavioral screen for use in rodents (primarily rats) has been incorporated into rodent studies since the late ...
S C Gad
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Several recent reports have demonstrated that acute solvent exposure in animals produces a profile of neurobehavioral effects similar to that of classical CNS depressant drugs such as the barbiturates and ethanol. The present investigation further delineated the behavioral pharmacology of three solvents [1,1,1-trichloroethane (TCE), ether, and ...
Jenny L. Wiley +2 more
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