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The functional observational battery in adult and developing rats.
Neurotoxicology, 2001Neurobehavioral screening methods, such as the functional observational battery (FOB), are now widely used to identify potential neurotoxicity of new and existing chemicals. These methods have been validated and a large database now exists for the effects of a wide range of chemicals.
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Toxicological Sciences, 1991
A Functional observational battery (FOB) was utilized to provide a semiquantitative description of the hyperreactivity, excitability, and debilitation produced by amitraz. Adult male Long-Evans rats were administered either vehicle or 10, 25, 50, 100, or 200 mg/kg amitraz ip.
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A Functional observational battery (FOB) was utilized to provide a semiquantitative description of the hyperreactivity, excitability, and debilitation produced by amitraz. Adult male Long-Evans rats were administered either vehicle or 10, 25, 50, 100, or 200 mg/kg amitraz ip.
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Current Protocols in Pharmacology, 2018
AbstractThe modified Irwin procedure or functional observational battery (FOB) can be used to achieve several goals. New chemical entities (NCEs) can be behaviorally screened for nervous system effects at a variety of doses to identify potential therapeutic uses and in the selection of appropriate doses for subsequent assays. NCEs can also be evaluated
Joanne R, Mathiasen, Virginia C, Moser
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AbstractThe modified Irwin procedure or functional observational battery (FOB) can be used to achieve several goals. New chemical entities (NCEs) can be behaviorally screened for nervous system effects at a variety of doses to identify potential therapeutic uses and in the selection of appropriate doses for subsequent assays. NCEs can also be evaluated
Joanne R, Mathiasen, Virginia C, Moser
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Neurotoxicology, 1998
The neurobehavioral consequences of inhalational exposure to carbon disulfide (CS2) were evaluated as part of a joint project between the National Institute of Environmental Health Sciences and the U.S. Environmental Protection Agency. Behavioral changes in rats were measured using a functional observational battery (FOB), which is a series of ...
V C, Moser +3 more
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The neurobehavioral consequences of inhalational exposure to carbon disulfide (CS2) were evaluated as part of a joint project between the National Institute of Environmental Health Sciences and the U.S. Environmental Protection Agency. Behavioral changes in rats were measured using a functional observational battery (FOB), which is a series of ...
V C, Moser +3 more
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Characterization of a functional observational battery in rodents and non human primates
Journal of Pharmacological and Toxicological Methods, 2011Philip J. Monroe +4 more
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2022 Australian & New Zealand Control Conference (ANZCC), 2022
Jaffar Ali Lone +2 more
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Jaffar Ali Lone +2 more
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VALIDATION OF AN ICH-COMPLIANT FUNCTIONAL OBSERVATIONAL BATTERY IN NON-HUMAN PRIMATES
Journal of Pharmacological and Toxicological Methods, 2007David V. Gauvin +2 more
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Method validation of functional observational battery assessment in rodents and nonhuman primates
Journal of Pharmacological and Toxicological Methods, 2013Yujuan Li, Na Niu, Qing Cai
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Journal of Pharmacological and Toxicological Methods, 2005
William S Redfern, Jean-Pierre Valentin
exaly
William S Redfern, Jean-Pierre Valentin
exaly