Results 261 to 270 of about 55,585 (303)
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Comparative functional observational battery study of twelve commercial pyrethroid insecticides in male rats following acute oral exposure

NeuroToxicology, 2009
Twelve commercial pyrethroid insecticides (technical-grade active ingredients) were evaluated individually for acute neurobehavioral manifestations of toxicity under conditions suited to assist with determining whether they act by a common mechanism of toxicity.
Myra L, Weiner   +4 more
openaire   +2 more sources

Short-Circuit Fault Diagnosis and State Estimation for Li-ion Battery using Weighting Function Self-Regulating Observer

2020 Prognostics and Health Management Conference (PHM-Besançon), 2020
A wrong estimation of Li-ion battery state of charge (SOC) can seriously affect the safety, the availability and the reliability of electrical-powered systems particularly for embedded applications. One of the main cause is the occurrence of non-detected battery soft short-circuit (SC).
Meng, Jianwen   +3 more
openaire   +1 more source

Neurotoxicity of acrylamide and 2,5-hexanedione in rats evaluated using a functional observational battery and pathological examination

Neurotoxicology and Teratology, 1992
The clinical effects of two neurotoxicants, acrylamide and 2,5-hexanedione, were compared in rats using a functional observational battery (FOB), which includes a series of home cage and open-field observations, sensorimotor measurements, and physiological parameters.
L, Shell   +3 more
openaire   +2 more sources

Spectrum of effects detected in the rat functional observational battery following oral administration of non-CNS targeted compounds

Journal of Pharmacological and Toxicological Methods, 2005
The Functional Observational Battery (FOB) is a systematic evaluation of nervous system function in the rat, comprising more than 30 parameters across autonomic, neuromuscular, sensorimotor and behavioural domains. We have collated FOB outcomes from 50 compounds that were not targeted at CNS disorders, and would therefore be anticipated to have ...
William S, Redfern   +7 more
openaire   +2 more sources

The functional observational battery in adult and developing rats.

Neurotoxicology, 2001
Neurobehavioral screening methods, such as the functional observational battery (FOB), are now widely used to identify potential neurotoxicity of new and existing chemicals. These methods have been validated and a large database now exists for the effects of a wide range of chemicals.
openaire   +1 more source

Investigations of Amitraz Neurotoxicity in Rats IV. Assessment of Toxicity Syndrome Using a Functional Observational Battery

Toxicological Sciences, 1991
A Functional observational battery (FOB) was utilized to provide a semiquantitative description of the hyperreactivity, excitability, and debilitation produced by amitraz. Adult male Long-Evans rats were administered either vehicle or 10, 25, 50, 100, or 200 mg/kg amitraz ip.
openaire   +2 more sources

Carbon disulfide neurotoxicity in rats: VII. Behavioral evaluations using a functional observational battery.

Neurotoxicology, 1998
The neurobehavioral consequences of inhalational exposure to carbon disulfide (CS2) were evaluated as part of a joint project between the National Institute of Environmental Health Sciences and the U.S. Environmental Protection Agency. Behavioral changes in rats were measured using a functional observational battery (FOB), which is a series of ...
V C, Moser   +3 more
openaire   +1 more source

Tolerance and sensitization to inhaled 1,1,1-trichloroethane in mice: results from open-field behavior and a functional observational battery

Psychopharmacology, 2006
1,1,1-Trichloroethane (TCE), a representative abused solvent, has well described acute behavioral effects in animals. Much less is known about repeated high-concentration exposures as would be encountered in inhalant abusers. Tolerance has been demonstrated in some, but not all, studies with TCE while sensitization has also been seen with other abused ...
Scott E, Bowen, Robert L, Balster
openaire   +2 more sources

Drug‐Induced Neurotoxicity Assessments: Validation of a Neurological and Functional Observation Battery in the Sinclair Miniature Swine

The FASEB Journal, 2016
The nervous system is one of the most complex organs in the body, and has its unique vulnerabilities to toxic compounds.
Alain Stricker‐Krongrad   +5 more
openaire   +1 more source

Screens in Neurotoxicity: Objectives, Design, and Analysis, with the Functional Observational Battery as a Case Example

Journal of the American College of Toxicology, 1989
Screening tests for detecting the presence or probable absence of a single end point (such as neurobehavioral activity) are the most common and important activities in toxicology. Objectives and characteristics of screens are presented and reviewed here, and the corresponding essential design features of a neurotoxicology screen are suggested.
openaire   +1 more source

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