Results 91 to 100 of about 934,400 (317)
Journal of Functional FoodsDoxorubicin (DOX) is a widely used chemotherapeutic agent, but its clinical application is limited by cardiotoxicity associated with oxidative stress, inflammation, and apoptosis. Cirsium setidens (C.
Ji-Hye Song +4 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Music Theory Online, 1995 The concept of harmonic function, far from carrying a unitary and universally understood meaning, has signified many different things to theorists past and present. This essay examines some of the different meanings commonly associated with the term today, as well as aspects of the harmonic theories of Rameau, Weber, and ...
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PROTEOMICS, 2004 AbstractThis report describes the first scientific meeting of the British Society for Proteome Research (BSPR), which was organised jointly with the European Bioinformatics Institute (EBI) and held in July 2004. The focus of the conference was functional proteomics with an emphasis on possible clinical application. The main subjects described here are:
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Frontiers in NutritionMetabolic dysfunction-associated steatotic liver disease (MASLD) is a global health issue that causes severe liver abnormalities and metabolic dysregulation, incurring substantial costs to healthcare systems.
Miri Park +8 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Facile Synthesis of Biomimetic Honeycomb Material with Biological Functionality
, 2013 A microfluidic approach to a honeycomb-structure material based on the synergistic effects of polymer rapid precipitation, double emulsion templating, and internal effervescent salt decomposition is reported.
Qin, Jianhua +12 more
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Quantifying human sweetness perception via a TAS1R2/TAS1R3-based model-predicted sweetness score
Food Chemistry: XArtificial sweeteners provide high-intensity sweetness with minimal caloric load, but their evaluation still relies heavily on subjective sensory panels. Psychophysical studies have reported parameters such as sweetness potency, perception threshold, and
Ajung Kim +4 more
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