Results 81 to 90 of about 1,108,492 (304)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Applied Biological ChemistryAge–related cognitive decline is closely associated with impairments in synaptic structure and function, particularly in the hippocampus. Ecklonia cava, a brown seaweed rich in phlorotannins, has been suggested to possess neuroprotective properties ...
Haeun Lee +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Functionality-based application confinement: parameterised hierarchical application restrictions [PDF]
, 2008 Traditional user-oriented access control models such as Mandatory Access Control (MAC) and Discretionary Access Control (DAC) cannot differentiate between processes acting on behalf of users and those behaving maliciously.
Payne, C., Schreuders, Z.C.
core
, 2018 Several prospective epidemiological studies have shown that there is a clear inverse relationship between serum highdensity lipoprotein-cholesterol (HDL-C) concentrations and risk for coronary heart disease (CHD), even at low-density lipoprotein ...
Constantine E Kosmas +7 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Supporting virtual documents in just-in-time hypermedia systems [PDF]
, 2004 Many analytical or computational applications especially legacy systems create documents and display screens in response to user queries "dynamically" or in "real time".
Oria, Vincent +7 more
core +2 more sources
npj Science of FoodChronic stress-induced dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis and glucocorticoid receptor (GR) signaling is central to the development of depression.
Minji Kim +4 more
doaj +1 more source
Molecules, 2020 Age-related macular degeneration (AMD) is a major cause of irreversible loss of vision with 80–90% of patients demonstrating dry type AMD. Dry AMD could possibly be prevented by polyphenol-rich medicinal foods by the inhibition of N-retinylidene-N ...
Dong Hee Kim +6 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source