Results 101 to 110 of about 6,527,060 (344)

Regulatory mechanisms of hepatocyte PCSK9 expression: translating mechanistic insights into potential nutraceuticals

Chinese Medicine
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a critical regulator of cholesterol metabolism in hepatocytes with profound implications for cardiovascular health. This review explores the intricate regulatory network that controls hepatic PCSK9
Seon Kyeong Park, Jin-Taek Hwang, Hyo-Kyoung Choi, Jangho Lee   +3 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Nutritional, functional, and metabolomic perspectives on traditional Korean fermented soybean pastes and Jeotgal: A focused review of Jang and Jeotgal

Journal of Ethnic Foods
Korean fermented soybean pastes (jang, including doenjang, ganjang, and gochujang) and jeotgal are characterized by their complex microbial ecosystems, rich nutrient composition, and notable health-promoting properties.
Yu Ra Lee, Sang-Hoon Lee
doaj   +1 more source

Williams’s Pragmatic Genealogy and Self-Effacing Functionality [PDF]

, 2018
In Truth and Truthfulness, Bernard Williams sought to defend the value of truth by giving a vindicatory genealogy revealing its instrumental value. But what separates Williams’s instrumental vindication from the indirect utilitarianism of which he was a ...
Queloz, Matthieu
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Genital Skin Diseases and Their Expression in Sexual Functionality [PDF]

, 2015
Sexual functionality acts as an important function of the individual, acting both physically and mentally to create a state of well-being and permitting procreation.
Albu, Gabriela, Georgescu, Simona Roxana, Sarbu, Maria Isabela, Tampa, Mircea   +3 more
core   +2 more sources

TRUTH-FUNCTIONALITY

The Review of Symbolic Logic, 2008
It is shown that the standard definitions of truth-functionality, though useful for their purposes, ignore some aspects of the usual informal characterisations of truth-functionality. An alternative definition is given that results in a stronger notion that pays attention to those aspects.
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protective Effects of Buckwheat and Isoquercitrin Against Noise‐Induced Hearing Loss in Mice: An Antioxidant Strategy Targeting the Nrf2/HO‐1 Pathway in Auditory Hair Cells

Food Frontiers
Noise‐induced hearing loss (NIHL) is a significant clinical challenge primarily due to oxidative stress‐related mechanisms. This study investigates an antioxidant strategy using Buckwheat (Fagopyrum esculentum Moench; BW) extracts and isoquercitrin (IQ),
Hojin Lee, Gahwa Jung, Guijae Yoo, Jonghoon Jung, Jae‐Yong Park, Changho Lee, Jaekwang Lee   +6 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source