Results 71 to 80 of about 1,337,466 (401)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Proteinous Components of Neutrophil Extracellular Traps Are Arrested by the Cell Wall Proteins of Candida albicans during Fungal Infection, and Can Be Used in the Host Invasion

Cells, 2021
One of defense mechanisms of the human immune system to counteract infection by the opportunistic fungal pathogen Candida albicans is the recruitment of neutrophils to the site of invasion, and the subsequent production of neutrophil extracellular traps (
Justyna Karkowska-Kuleta, Magdalena Smolarz, Karolina Seweryn-Ozog, Dorota Satala, Marcin Zawrotniak, Ewelina Wronowska, Oliwia Bochenska, Andrzej Kozik, Angela H. Nobbs, Mariusz Gogol, Maria Rapala-Kozik   +10 more
doaj   +1 more source

Exploring the utility of Brachypodium distachyon as a model pathosystem for the wheat pathogen Zymoseptoria tritici [PDF]

, 2015
peer-reviewedBackground Zymoseptoria tritici, the causative organism of Septoria tritici blotch disease is a prevalent biotic stressor of wheat production, exerting substantial economic constraints on farmers, requiring ...
Doohan, Fiona, Mullins, Ewen, O'Driscoll, Aoife   +2 more
core   +1 more source

The genomic determinants of adaptive evolution in a fungal pathogen

Evolution Letters, 2019
Unravelling the strength, frequency, and distribution of selective variants along the genome as well as the underlying factors shaping this distribution are fundamental goals of evolutionary biology.
Jonathan Grandaubert, J. Dutheil, E. Stukenbrock   +2 more
semanticscholar   +1 more source

Microbiome manipulation by a soil-borne fungal plant pathogen using effector proteins

Nature Plants, 2020
During colonization of their hosts, pathogens secrete effector proteins to promote disease development through various mechanisms. Increasing evidence shows that the host microbiome plays a crucial role in health, and that hosts actively shape their ...
Nick C. Snelders, Hanna Rovenich, Gabriella C. Petti, M. Rocafort, G. V. D. van den Berg, J. Vorholt, J. Mesters, Michael F. Seidl, R. Nijland, B. Thomma   +9 more
semanticscholar   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

The Plant Salicylic Acid Signalling Pathway Regulates the Infection of a Biotrophic Pathogen in Grasses Associated with an Epichloë Endophyte

Journal of Fungi, 2021
The study of the contribution of the plant defence hormones, salicylic acid (SA) and jasmonic acid (JA), in the resistance against pathogens of plants associated with Epichloë fungal endophytes has been scanty. We hypothesised that Epichloë spp., capable
Ming-Zhu Kou, Daniel A. Bastías, Michael J. Christensen, Rui Zhong, Zhi-Biao Nan, Xing-Xu Zhang   +5 more
doaj   +1 more source

Gene expression differs in susceptible and resistant amphibians exposed to Batrachochytrium dendrobatidis. [PDF]

, 2018
Chytridiomycosis, the disease caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has devastated global amphibian biodiversity. Nevertheless, some hosts avoid disease after Bd exposure even as others experience near-complete extirpation ...
Eskew, Evan A, Foley, Janet E, Keel, Kevin, LaDouceur, Elise EB, Miller, Michael R, Shock, Barbara C, Todd, Brian D   +6 more
core   +2 more sources

Captivity and Infection by the Fungal Pathogen Batrachochytrium salamandrivorans Perturb the Amphibian Skin Microbiome

Frontiers in Microbiology, 2019
The emerging fungal pathogen, Batrachochytrium salamandrivorans (Bsal) is responsible for the catastrophic decline of European salamanders and poses a threat to amphibians globally.
K. Bates, Jennifer M. G. Shelton, V. Mercier, K. Hopkins, X. Harrison, S. Petrovan, M. Fisher   +6 more
semanticscholar   +1 more source

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source