Results 71 to 80 of about 6,289,194 (323)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Interactions between fungal hyaluronic acid and host CD44 promote internalization by recruiting host autophagy proteins to forming phagosomes

iScience, 2021
Summary: Phagocytosis and autophagy play critical roles in immune defense. The human fungal pathogen Cryptococcus neoformans (Cn) subverts host autophagy-initiation complex (AIC)-related proteins, to promote its phagocytosis and intracellular parasitism ...
Shengli Ding, Jing Yang, Xuehuan Feng, Aseem Pandey, Rola Barhoumi, Dongmei Zhang, Samantha L. Bell, Yue Liu, Luciana Fachini da Costa, Allison Rice-Ficht, Robert O. Watson, Kristin L. Patrick, Qing-Ming Qin, Thomas A. Ficht, Paul de Figueiredo   +14 more
doaj   +1 more source

Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen [PDF]

, 2017
The authors thank E. Veal for intellectual input. This work was funded by the UK Biotechnology and Biological Research Council [J.Q. BB/K016393/1; A.J.P.B.
Brown, Alistair J P, Day, Alison M, Herrero-de-Dios, Carmen M., MacCallum, Donna M, Quinn, Janet   +4 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Use of the Fluorescent Dye Thioflavin T to Track Amyloid Structures in the Pathogenic Yeast Candida albicans

Bio-Protocol
The human pathogenic yeast Candida albicans can attach to epithelial cells or indwelling medical devices to form biofilms. These microbial communities are highly problematic in the clinic as they reduce both sensitivity to antifungal drugs and detection ...
Thierry Mourer, Christophe d'Enfert, Sophie Bachellier-Bassi   +2 more
doaj   +1 more source

Cryo-Electron Tomography of Candida glabrata Plasma Membrane Proteins

Journal of Fungi, 2021
Fungal plasma membrane proteins have long been recognized as targets for the development of antifungal agents. Despite recent progress in experimental approaches and computational structural predictions, our knowledge of the structural dynamics and ...
Cristina Jiménez-Ortigosa, Jennifer Jiang, Muyuan Chen, Xuyuan Kuang, Kelley R. Healey, Paul Castellano, Nikpreet Boparai, Steven J. Ludtke, David S. Perlin, Wei Dai   +9 more
doaj   +1 more source

Transcriptomic analysis of field-droughted sorghum from seedling to maturity reveals biotic and metabolic responses. [PDF]

, 2019
Drought is the most important environmental stress limiting crop yields. The C4 cereal sorghum [Sorghum bicolor (L.) Moench] is a critical food, forage, and emerging bioenergy crop that is notably drought-tolerant.
Baker, Christopher R, Blow, Matthew J, Cole, Benjamin, Coleman-Derr, Devin, Dahlberg, Jeffery, DeGraaf, Stephanie, Gao, Cheng, Harrison, Maria J, Hollingsworth, Joy, Hutmacher, Robert, Jansson, Christer, Jeffers, Tim, Lemaux, Peggy G, Madera, Mary, Niyogi, Krishna K, O'Malley, Ronan C, Owiti, Judith A, Patel, Dhruv, Pierroz, Grady, Purdom, Elizabeth, Sievert, Julie, Singan, Vasanth R, Taylor, John W, Varoquaux, Nelle, Visel, Axel, Vogel, John P, Xu, Ling, Yoshinaga, Yuko   +27 more
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Identifying Potential Molecular Targets in Fungi Based on (Dis)Similarities in Binding Site Architecture with Proteins of the Human Pharmacolome

Molecules, 2023
Invasive fungal infections represent a public health problem that worsens over the years with the increasing resistance to current antimycotic agents.
Johann E. Bedoya-Cardona, Marcela Rubio-Carrasquilla, Iliana M. Ramírez-Velásquez, Mario S. Valdés-Tresanco, Ernesto Moreno   +4 more
doaj   +1 more source

Membrane fluidity and temperature sensing are coupled via circuitry comprised of Ole1, Rsp5, and Hsf1 in Candida albicans [PDF]

, 2014
Peer reviewedPublisher ...
Cowen, Leah E., Leach, Michelle D.
core   +1 more source