Results 81 to 90 of about 4,257 (227)

PROMISING SCAFFOLD AND TREATMENT FOR ULCERATIVE COLITIS: ISOLATION, IN VIVO AND IN SILICO STUDIES [PDF]

Egyptian Journal of Desert Research
Methoxsalen compound was isolated from Ammi majus seeds in very good amount, purity (almost 90%) and few steps method which don’t include column chromatography (extraction by ethanol, extraction by dichloromethane, crystallization by methanol (60%) and ...
Ahmed Selim
doaj   +1 more source

A Coumarin Compound Derived From Zanthoxylum avicennae Reduces the Pathogenicity of Fusarium verticillioides by Directly Binding to and Inhibiting Glycoside Hydrolase 3 Activity

Molecular Plant Pathology, Volume 27, Issue 2, February 2026.
Luvangetin, a coumarin compound from Zanthoxylum avicennae roots, affects the cell wall degradation capacity and pathogenicity of Fusarium verticillioides on maize. Integrated transcriptomic, proteomic and in vitro activity analyses revealed that it binds to three critical sites of the Fusarium glycoside hydrolase 3 family (GH3) β‐glucosidase ...
Duxuan Liu, Jing Hua, Haoyu Chen, Mingjie Wu, Zhiqing Mao, Zhen Yang, Xiubin Xu, Yanhong Hua, Chenwei Feng, Kun Zhang, Jiahuan Chen   +10 more
wiley   +1 more source

Extraction of Coumarins from Leaves, Petioles, Stems and Roots of Ruta graveolens and Nicotiana benthamiana

Bio-Protocol, 2012
This method describes the extraction of coumarins and furanocoumarins from leaves of Ruta graveolens (a natural furanocoumarin) producer, and Nicotiana benthamiana.
Alain Hehn, Guilhem Vialart, Alexandre Olry, Frederic Bourgaud   +3 more
doaj   +1 more source

Furanocoumarins from the Roots of Angelica dahurica with Inhibitory Activity against Intracellular Reactive Oxygen Species Accumulation.

Journal of Natural Products, 2019
Five new furanocoumarins, dahuribirin H (1), dahuribirin I (2), (2'S)-(+)-5-(2'-hydroxy-3'-methylbut-3'-enyloxy)-8-(3''-methylbut-2″-enyloxy)psoralen (3), (2'R)-(+)-5-(2',3'-epoxy-3'-methylbutoxy)-8-(3″-methylbut-2″-enyloxy)psoralen (4), and 5-methoxy-8-(
U. Kang, Ah-Reum Han, Yangkang So, C. Jin, S. Ryu, Dongho Lee, E. Seo   +6 more
semanticscholar   +1 more source

Bioscreening of Oxypeucedanin, a Known Furanocoumarin

Iranian Journal of Basic Medical Sciences, 2010
Objective(s)As an important class of natural products, coumarins exhibit many biological activities and the diversity of their bioactivity is so huge that the pharmacological promiscuity has been applied on their case. Oxypeucedanine also named as prangolarin is a linear furanocoumarin with an oxygenated prenylated substitution at C-5 of the nucleus ...
Razavi, Seyed Mehdi, Zahri, Saber, Motamed, Zahra, Ghasemi, Ghader   +3 more
openaire   +2 more sources

Assessment of the Intestinal CYP3A Contribution to Drug Interactions with Extended‐Release Tacrolimus (LCPT) Using Grapefruit Juice

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract Grapefruit juice (GFJ) is a known inhibitor of intestinal cytochrome P450 3A (CYP3A) metabolism leading to increased exposure to CYP3A substrates such as tacrolimus. The extended‐release tacrolimus formulation Envarsus (LCPT) exhibits prolonged absorption throughout the entire GI tract.
Adekunle Alabi, Janice S. Kerr, Mita Shah, Adnan Khan, Joseph D. Ma, Raymond T. Suhandynata, Jeremiah D. Momper, Shirley M. Tsunoda   +7 more
wiley   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

CYP98A22, a phenolic ester 3’-hydroxylase specialized in the synthesis of chlorogenic acid, as a new tool for enhancing the furanocoumarin concentration in Ruta graveolens

BMC Plant Biology, 2012
Background Furanocoumarins are molecules with proven therapeutic properties and are produced in only a small number of medicinal plant species such as Ruta graveolens.
Karamat Fazeelat, Olry Alexandre, Doerper Sébastien, Vialart Guilhem, Ullmann Pascaline, Werck-Reichhart Danièle, Bourgaud Frédéric, Hehn Alain   +7 more
doaj   +1 more source

Furanocoumarins with potential antiproliferative activities from Clausena lenis

Natural Product Research, 2019
A phytochemical investigation on the stems and leaves of Clausena lenis led to the isolation of a new furanocoumarin, clauselenisin A (1), together with five known analogues (2–6).
Yan-Ping Liu, Q. Wen, Shih-en Hu, Yan-Lei Ma, Zhi-Hua Jiang, Jin-ying Tang, Yan-Hui Fu, S. Qiu   +7 more
semanticscholar   +1 more source

Inhibitory Effects of Intestinal Cytochrome P450 3A by Furanocoumarins in Kampo Extracted Medicines [PDF]

, 2014
departmental bulletin ...
林, 真奈美, 岡本, 玲, 171, 172, 岩永, 一範, 173   +5 more
core