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Diversity-Oriented Synthesis and Antibiofilm Evaluation of Furan-2-Carboxamides. [PDF]

open access: yesChemMedChem
Muñoz-Estrada AC   +4 more
europepmc   +1 more source
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Two furanone glucoside derivatives from Juniperus phœnicea

Phytochemistry, 1996
Abstract The rare compound, psydrin (5-methyl-4-O-(β- d -glucopyranosyl)-3(2H)-furanone) and the new 5-methyl-4-O-(β- d -glucopyranosyl)-3(2-isopropylidenyl)-furanone have been isolated from an acetone extract of the aerial parts of Juniperus phœnicea . Structural elucidation of the new product was achieved mainly by spectroscopic methods.
Joseph Vercauteren   +2 more
exaly   +2 more sources

Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors

European Journal of Medicinal Chemistry, 2017
Cdc7 is a serine-threonine kinase and plays a conserved and important role in DNA replication, and it has been recognized as a potential anticancer target. Herein, we report the design, synthesis and structure-activity relationship of novel furanone derivatives as Cdc7 kinase inhibitors.
Takayuki Irie   +2 more
exaly   +3 more sources

γ -Butenolide and furanone derivatives from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178

Phytochemistry, 2017
Chromatographic separation of the broth extract of the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178 resulted in isolation of four γ-butenolide-furanone dimers, aspersclerotiorones A-D, a furanone derivative, aspersclerotiorone E, and two γ-butenolide derivatives, aspersclerotiorones F and G, together with six known compounds, penicillic ...
Souwalak Phongpaichit   +2 more
exaly   +3 more sources

Anti-Cryptococcal activity of a furanone derivative–antibiofilm and opsonophagocytic potential

Journal de Mycologie Médicale, 2020
Cryptococcus neoformans, an encapsulated fungal pathogen is evolving as a major threat to immune-compromised patients and rarely to healthy individuals also. The cell wall bound capsular polysaccharide, melanin pigment and biofilm formation are major virulence factors that are known to contribute to cryptococcal meningitis.
S S, Rathore   +5 more
openaire   +2 more sources

Furanone derivatives as quorum-sensing antagonists of Pseudomonas aeruginosa

Applied Microbiology and Biotechnology, 2008
The biofilm formation of Pseudomonas aeruginosa, an opportunistic human pathogen, is developed by cell-to-cell signaling, so-called quorum sensing (QS). To control the biofilm formation, we designed and synthesized new QS inhibitors of P. aeruginosa based on the structure of the previously known QS inhibitor, furanone.
Cheoljin, Kim   +6 more
openaire   +2 more sources

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