Results 101 to 110 of about 39,041 (288)

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Effects of compost and digestate on environment and plant production – results of two research projects [PDF]

, 2008
A yearly amount of 9.3x106t compost and digestate derived from separately collected organic waste is produced in the 25 European Union member states. The improvement of soil properties is a major benefit of compost application.
Berner, Alfred, Fuchs, Jacques G., Kupper, Thomas, Mayer, Jochen, Schleiss, Konrad   +4 more
core  

Structure‐based design, synthesis and biological evaluation of bis‐tetrahydropyran furan acetogenin mimics targeting the trypanosomatid F1 component of ATP synthase [PDF]

, 2019
This work was funded by the Leverhulme Trust (G.J.F.), Wellcome Trust ISSF support (G.J.F./T.K.S.) and the European Community’s Seventh Framework Programme under grant agreement No.
, Abrahams, Boyall, Boyall, Brand, Brun, Brun, Calter, Cullia, Delespaux, Florence, Florence, Florence, Florence, Fraser, Gould, Gupta, Hashmi, Hashmi, Hirth, Hoye, Ji, Kel'in, Kusumi, Kusumi, Lanteri, Marshall, Marshall, Marshall, Mesu, Minetto, Montgomery, Morris, Nagle, Ohtani, Pollastri, Pridmore, Schneider, Srivastava, Steverding, Trott, Tulloch, Wilkinson, Wyllie   +43 more
core   +3 more sources

Identification of Metabolites of the Dietary Supplement Ingredient 5α‐Hydroxy‐Laxogenin

Drug Testing and Analysis, EarlyView.
The biotransformation of the dietary supplement ingredient 5α‐hydroxy‐laxogenin was investigated using human HepG2 cells, the rat and in silico using the online software Next‐gen E‐Resource for Drug Discovery (NERDD). We identified five metabolites generated by the human HepG2 cells of which three and an additional mono‐hydroxylated metabolite were ...
Daniel Derwand, Oliver Zierau, Detlef Thieme, Annekathrin Martina Keiler   +3 more
wiley   +1 more source

Directed Hole Localization Stabilizing Interfacial Sulfur Species to Boost α‐C–H Activation for Selective Biomass Photo‐oxidation

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Efficient α‐C–H bond activation and directional conversion for selective biomass photo‐oxidation are achieved by integrating polarization and interface engineering strategies in P‐doped ZnIn2S4 polar photocatalysts, which leverage hole localization and stable interfacial sulfur species, endowing bio‐based HMF at 94.4% conversion with 94.5% selectivity ...
Yinyin He, Jie Li, Shunmugavel Saravanamurugan, Hu Li   +3 more
wiley   +1 more source

Heteroaryl‐Substituted Polyfluorobiaryls Synthesis via Palladium‐Catalyzed Double CH Bond Functionalization Using Palladium 1,4‐Migration Associated to Direct Arylation

European Journal of Organic Chemistry, EarlyView.
Fluoro substituents on a benzene ring linked to a 2‐bromoaryl group enables the selective activation of one of its CH bonds via Pd‐1,4‐migration. Then, Pd‐catalyzed direct coupling with heteroarenes produces C2’‐heteroarylated 1,1′‐biaryls. In this reaction, the new C–C bond arises from the functionalization of two CH bonds.
Norman Le Floch, Thierry Roisnel, Henri Doucet   +2 more
wiley   +1 more source

Photochemical reactions of biomass derived platform chemicals

Frontiers in Chemistry
Platform chemicals obtained from biomass will play an important role in chemical industry. Already existing compounds or not yet established chemicals are produced from this renewable feedstock. Using photochemical reactions as sustainable method for the
Norbert Hoffmann, Mario Andrés Gomez Fernandez, Arthur Desvals, Corentin Lefebvre, Clément Michelin, Mohammed Latrache   +5 more
doaj   +1 more source

Synthesis of perhydrofuro[2,3-b]furans from isopentenyl alcohol through carbonyl-ene and wacker-type reactions [PDF]

, 2011
A range of 2-substituted perhydrofuro[2,3-b]furans have been synthesized in a stereoselective manner through a sequence involving the Lewis-acid catalyzed carbonyl-ene reaction of a protected isopentenyl alcohol with a variety of enophiles, deprotection ...
Alonso, Alonso, Alonso, Alonso, Alonso, Alonso, Alonso, Alonso, Alonso, Alonso, Alonso, Alonso, Alonso, Alonso, Alonso, Boneva, Caprio, Chen, Clarke, Corey, Dacunha, de la Torre, Evans, Hao, Henry, Hosokawa, Huang, Jyothi, Keith, Kido, Kido, Klein Gebbinck, Klein Gebbinck, Kolodziuk, Lorenzo, Lorenzo, Luo, Luo, Malakov, Malakov, Malakov, Malakov, Meléndez, Mikami, Mikami, Mikami, Mikami, Muzart, Muzart, Muzart, Okachi, Okachi, Roggenbuck, Rosselli, Salomon, Snider, Stewart, Tateiwa, Tsuji, Vader, Wu, Zheng   +61 more
core   +1 more source

Additives Promote Divergent Reactivity in Photolytic Deoxygenation and Lactonization Reactions of Cobalt Alkoxycarbonyls

European Journal of Organic Chemistry, EarlyView.
We report a carbonylation‐homolysis process to access acyl radicals that can undergo decarboxylation or cyclization onto tethered alkenes. In both cases, ligands and additives are shown to influence the outcome to give saturated or unsaturated products, in some cases with isomerization of the initial products.
Jacob N. Hackbarth, Dana R. Chambers, Cory T. Ludwig, Tyler K. Brown, David B. C. Martin   +4 more
wiley   +1 more source

Borane catalysed ring opening and closing cascades of furans leading to silicon functionalized synthetic intermediates

Nature Communications, 2016
Furans are attractive staring materials in organic chemistry, due to the ease of functionalisation and sourcing from renewable feedstocks. Here the authors show the ring opening of furans to silane intermediates, followed by further conversion to ...
Chinmoy K. Hazra, Narasimhulu Gandhamsetty, Sehoon Park, Sukbok Chang   +3 more
doaj   +1 more source