Results 51 to 60 of about 27,241 (159)
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
An update on the landscape of collagen bioactive fragments
The FEBS Journal, EarlyView.The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley +1 more source
Furin‐mediated protein processing in infectious diseases and cancer
Clinical & Translational Immunology, 2019 Proteolytic cleavage regulates numerous processes in health and disease. One key player is the ubiquitously expressed serine protease furin, which cleaves a plethora of proteins at polybasic recognition motifs.
Elisabeth Braun, Daniel Sauter
doaj +1 more source
The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation
The FEBS Journal, EarlyView.The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak +7 more
wiley +1 more source
Proprotein convertase furin regulates apoptosis and proliferation of granulosa cells in the rat ovary. [PDF]
PLoS ONE, 2013 Folliculogenesis is tightly controlled by a series of hormones, growth factors and cytokines, many of which are secreted as proproteins and require processing by proteases before becoming functional.
Xiaokui Yang +8 more
doaj +1 more source
Significance of Furin Expression in Thyroid Neoplastic Transformation
Cancers, 2023 Angiotensin-Converting Enzyme 2 (ACE2), Transmembrane Serine Protease 2 (TMPRSS2), and Furin were known to be key players in the SARS-CoV-2 infection, and the thyroid gland was revealed to be one of the relevant targets of the virus. Regardless of the viral infection, the expression of these molecules in the thyroid gland and their putative role in the
Maria Teresa Azevedo +8 more
openaire +3 more sources
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
Furin cleavage of the HIV‐1 Tat protein [PDF]
FEBS Letters, 2004 Extracellular human immunodeficiency virus‐1 (HIV‐1) Tat protein and Tat‐derived peptides are biologically active but mechanisms of Tat processing are not known. Within the highly conserved basic region of HIV‐1 Tat protein (amino acids, a.a. 48–56), we identified two putative furin cleavage sites and showed that Tat protein was cleaved in vitro at the
Tikhonov, Ilia +4 more
openaire +2 more sources
The role of peripheral serotonin in SARS‐CoV‐2 infectivity, COVID‐19 treatment and long COVID
Immunology &Cell Biology, EarlyView.In this article, we discuss how SARS‐CoV‐2 infects the gastrointestinal tract, that enterochromaffin cells, the source of circulating serotonin, uniquely express viral entry receptors. We examine how this infection disrupts gut‐derived serotonin, contributing to gastrointestinal symptoms and disease severity, and link elevated plasma serotonin to COVID‐
Daniel W Thorpe +6 more
wiley +1 more source
Biochemistry Research International, 2011 Although MMP-28 is involved in numerous important physiologic and pathologic conditions, the mechanisms of action of this secreted proteinase is not well understood.
Maria Pavlaki +5 more
doaj +1 more source